Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor.


:At early developmental stages (embryonic day 7, E7), chick paravertebral sympathetic ganglia contain a cell population that divides in culture while expressing various neuronal properties. In an attempt to identify factors that control neuronal proliferation, we found that ciliary neurotrophic factor (CNTF) specifically inhibits the proliferation of those cells expressing neuronal markers. In addition, CNTF affects the differentiation of sympathetic ganglion cells by inducing the expression of vasoactive intestinal peptide immunoreactivity (VIP-IR). After 1 day in culture, tyrosine hydroxylase immunoreactivity (TH-IR) was expressed by about 86% of the cells whereas VIP-IR was virtually absent. In the presence of CNTF, 50%-60% of the cells expressed VIP-IR after 4 days in culture; however, none of the cells expressed VIP-IR in the absence of CNTF. These results, and the demonstration of cells that express both VIP and TH-IR, indicate that VIP is induced in cells that initially express tyrosine hydroxylase. The findings suggest a potential role for CNTF as a factor affecting the proliferation and differentiation of developing sympathetic neurons.






Ernsberger U,Sendtner M,Rohrer H




Has Abstract


1989-03-01 00:00:00
















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    pub_type: 杂志文章


    authors: Ghosh DD,Sanders T,Hong S,McCurdy LY,Chase DL,Cohen N,Koelle MR,Nitabach MN

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  • Dissecting Modulatory Effects of Visual Attention in Primate Lateral Prefrontal Cortex Using Signal Detection Theory.

    abstract::In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...


    pub_type: 评论,杂志文章


    authors: Martinez-Trujillo J,Gulli RA

    更新日期:2018-03-21 00:00:00

  • Cerebral responses to change in spatial location of unattended sounds.

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    pub_type: 杂志文章


    authors: Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

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    authors: Krasnoperov VG,Bittner MA,Beavis R,Kuang Y,Salnikow KV,Chepurny OG,Little AR,Plotnikov AN,Wu D,Holz RW,Petrenko AG

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    authors: Hammang JP,Baetge EE,Behringer RR,Brinster RL,Palmiter RD,Messing A

    更新日期:1990-05-01 00:00:00

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    authors: Ellerby LM

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    authors: Philippidou P,Dasen JS

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    pub_type: 杂志文章


    authors: Lee SJ,Montell C

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    pub_type: 评论,杂志文章


    authors: Rainer G

    更新日期:2007-02-01 00:00:00

  • Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function.

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    pub_type: 杂志文章,评审


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    authors: Shackleford GM,Willert K,Wang J,Varmus HE

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    pub_type: 评论,杂志文章,评审


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    pub_type: 评论,杂志文章


    authors: Simerly R

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Vilberg KL,Davachi L

    更新日期:2013-09-18 00:00:00

  • Neural correlates of variations in event processing during learning in central nucleus of amygdala.

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    pub_type: 杂志文章


    authors: Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

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    pub_type: 评论,杂志文章


    authors: Dudman JT,Siegelbaum SA

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  • Active maintenance of associative mnemonic signal in monkey inferior temporal cortex.

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    pub_type: 杂志文章


    authors: Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Y

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  • Two types of ryanodine receptors in mouse brain: skeletal muscle type exclusively in Purkinje cells and cardiac muscle type in various neurons.

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    pub_type: 杂志文章


    authors: Kuwajima G,Futatsugi A,Niinobe M,Nakanishi S,Mikoshiba K

    更新日期:1992-12-01 00:00:00

  • Light-dependent translocation of visual arrestin regulated by the NINAC myosin III.

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    pub_type: 杂志文章


    authors: Lee SJ,Montell C

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  • Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling.

    abstract::The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unkn...


    pub_type: 杂志文章


    authors: Li J,Gu X,Ma Y,Calicchio ML,Kong D,Teng YD,Yu L,Crain AM,Vartanian TK,Pasqualini R,Arap W,Libermann TA,Snyder EY,Sidman RL

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  • BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease.

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    pub_type: 杂志文章


    authors: Phillips HS,Hains JM,Armanini M,Laramee GR,Johnson SA,Winslow JW

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  • Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments.

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    pub_type: 杂志文章


    authors: Morishima-Kawashima M,Hasegawa M,Takio K,Suzuki M,Titani K,Ihara Y

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  • Motor Learning Consolidates Arc-Expressing Neuronal Ensembles in Secondary Motor Cortex.

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    pub_type: 杂志文章


    authors: Cao VY,Ye Y,Mastwal S,Ren M,Coon M,Liu Q,Costa RM,Wang KH

    更新日期:2015-06-17 00:00:00