Abstract：
:Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ordered binding model in which a voltage-dependent Na+ binding is followed by a voltage-independent kainate binding. At -80 mV, two charges are translocated per molecule of glutamate, with a cycling time of approximately 70 ms, which is significantly slower than the predicted time course of synaptically released glutamate. The results suggest that glutamate diffusion and binding to transporters, rather than uptake, are likely to dominate the synaptic concentration decay kinetics.
journal_name
Neuronjournal_title
Neuronauthors
Wadiche JI,Arriza JL,Amara SG,Kavanaugh MPdoi
10.1016/0896-6273(95)90340-2subject
Has Abstractpub_date
1995-05-01 00:00:00pages
1019-27issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(95)90340-2journal_volume
14pub_type
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