Effects of long-term visual experience on responses of distinct classes of single units in inferior temporal cortex.

abstract：:Input-timing-dependent plasticity (ITDP) is a circuit-based synaptic learning rule by which paired activation of entorhinal cortical (EC) and Schaffer collateral (SC) inputs to hippocampal CA1 pyramidal neurons (PNs) produces a long-term enhancement of SC excitation. We now find that paired stimulation of EC and SC in...

journal_title：Neuron

authors： Leroy F,Brann DH,Meira T,Siegelbaum SA

更新日期：2017-08-30 00:00:00

abstract：:A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...

journal_title：Neuron

authors： Carlson TA,He S

更新日期：2004-09-16 00:00:00

abstract：:Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons...

journal_title：Neuron

authors： Dulcis D,Lippi G,Stark CJ,Do LH,Berg DK,Spitzer NC

更新日期：2017-09-13 00:00:00

abstract：:Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of the Dp(16) mouse mod...

journal_title：Neuron

authors： Pinto B,Morelli G,Rastogi M,Savardi A,Fumagalli A,Petretto A,Bartolucci M,Varea E,Catelani T,Contestabile A,Perlini LE,Cancedda L

更新日期：2020-12-09 00:00:00

abstract：:Vertebrate rod and cone photoreceptors hyperpolarize when illuminated. However, synaptic input from horizontal cells can depolarize cones and even elicit action potentials. Using the whole-cell tight-seal recording technique, we determined that, in solitary cones isolated from a lizard retina, action potentials can be...

journal_title：Neuron

authors： Maricq AV,Korenbrot JI

更新日期：1988-08-01 00:00:00

abstract：:Circadian rhythms are entrained to the natural day:night cycle. Melanopsin expressed in retinal ganglion cells partially accounts for circadian photoentrainment. Dkhissi-Benyahya et al. demonstrate that medium wavelength opsin (MW-opsin) also plays an important role in the process. Furthermore, they develop a model ex...

journal_title：Neuron

authors： Panda S

更新日期：2007-03-01 00:00:00

abstract：:Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefin...

journal_title：Neuron

authors： Sanders DW,Kaufman SK,DeVos SL,Sharma AM,Mirbaha H,Li A,Barker SJ,Foley AC,Thorpe JR,Serpell LC,Miller TM,Grinberg LT,Seeley WW,Diamond MI

更新日期：2014-06-18 00:00:00

abstract：:Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...

journal_title：Neuron

authors： Kalil K,Dent EW

更新日期：2004-06-24 00:00:00

abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...

journal_title：Neuron

authors： Flucher BE,Morton ME,Froehner SC,Daniels MP

更新日期：1990-09-01 00:00:00

abstract：:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...

journal_title：Neuron

authors： Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada C

更新日期：1996-10-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) coupled to phosphoinositide hydrolysis desensitize in response to prolonged or repeated agonist exposure, and evidence suggests that this involves activation of protein kinase C (PKC). The present studies were undertaken to determine if cloned mGluR5 undergoes similar PKC-medi...

journal_title：Neuron

authors： Gereau RW 4th,Heinemann SF

更新日期：1998-01-01 00:00:00

abstract：:We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...

journal_title：Neuron

authors： Hirbec H,Francis JC,Lauri SE,Braithwaite SP,Coussen F,Mulle C,Dev KK,Coutinho V,Meyer G,Isaac JT,Collingridge GL,Henley JM

更新日期：2003-02-20 00:00:00

abstract：:Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...

journal_title：Neuron

authors： Krol A,Wimmer RD,Halassa MM,Feng G

更新日期：2018-04-18 00:00:00

abstract：:We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden. We combined data from 5,745 cases and 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 cas...

journal_title：Neuron

authors： Pocklington AJ,Rees E,Walters JT,Han J,Kavanagh DH,Chambert KD,Holmans P,Moran JL,McCarroll SA,Kirov G,O'Donovan MC,Owen MJ

更新日期：2015-06-03 00:00:00

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments, codes for active agrin. Examination of the sequence reveals cons...

journal_title：Neuron

authors： Tsim KW,Ruegg MA,Escher G,Kröger S,McMahan UJ

更新日期：1992-04-01 00:00:00

abstract：:Perceptual inference is biased by foreknowledge about what is probable or possible. How prior expectations are neurally represented during visual perception, however, remains unknown. We used functional magnetic resonance imaging to measure brain activity in humans judging simple visual stimuli. Perceptual decisions w...

journal_title：Neuron

authors： Summerfield C,Koechlin E

更新日期：2008-07-31 00:00:00

abstract：:The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamoc...

journal_title：Neuron

authors： Dufour A,Seibt J,Passante L,Depaepe V,Ciossek T,Frisén J,Kullander K,Flanagan JG,Polleux F,Vanderhaeghen P

更新日期：2003-07-31 00:00:00

abstract：:Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...

journal_title：Neuron

authors： Cowan CW,Shao YR,Sahin M,Shamah SM,Lin MZ,Greer PL,Gao S,Griffith EC,Brugge JS,Greenberg ME

更新日期：2005-04-21 00:00:00

abstract：:Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...

journal_title：Neuron

authors： Maruyama M,Shimada H,Suhara T,Shinotoh H,Ji B,Maeda J,Zhang MR,Trojanowski JQ,Lee VM,Ono M,Masamoto K,Takano H,Sahara N,Iwata N,Okamura N,Furumoto S,Kudo Y,Chang Q,Saido TC,Takashima A,Lewis J,Jang MK,Aoki I,

更新日期：2013-09-18 00:00:00

abstract：:In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...

journal_title：Neuron

authors： Pitkow X

更新日期：2016-10-19 00:00:00

abstract：:Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...

journal_title：Neuron

authors： Stepanyants A,Tamás G,Chklovskii DB

更新日期：2004-07-22 00:00:00

abstract：:The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...

journal_title：Neuron

authors： Robitaille R

更新日期：1998-10-01 00:00:00

abstract：:Deciding when to exploit what is already known and when to explore new possibilities is crucial for adapting to novel and dynamic environments. Using reinforcement-based decision making, Costa et al. (2019) in this issue of Neuron find that neurons in the amygdala and ventral-striatum differentially signal the benefit...

journal_title：Neuron

authors： Reitich-Stolero T,Aberg KC,Paz R

更新日期：2019-08-07 00:00:00

abstract：:Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...

journal_title：Neuron

authors： Zhou Z,Liu X,Chen S,Zhang Z,Liu Y,Montardy Q,Tang Y,Wei P,Liu N,Li L,Song R,Lai J,He X,Chen C,Bi G,Feng G,Xu F,Wang L

更新日期：2019-08-07 00:00:00

abstract：:KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PI...

journal_title：Neuron

authors： Makuch L,Volk L,Anggono V,Johnson RC,Yu Y,Duning K,Kremerskothen J,Xia J,Takamiya K,Huganir RL

更新日期：2011-09-22 00:00:00

abstract：:Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...

journal_title：Neuron

authors： Schlag JD,Schlag-Rey M

更新日期：2009-06-11 00:00:00

abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...

journal_title：Neuron

authors： Davis AF,Bai J,Fasshauer D,Wolowick MJ,Lewis JL,Chapman ER

更新日期：1999-10-01 00:00:00

abstract：:Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that ...

journal_title：Neuron

authors： Nguyen-Ba-Charvet KT,Chédotal A

更新日期：2006-05-18 00:00:00

abstract：:Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...

journal_title：Neuron

authors： Romo R,Hernández A,Zainos A,Brody CD,Lemus L

更新日期：2000-04-01 00:00:00