Abstract：
:Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments, codes for active agrin. Examination of the sequence reveals considerable similarity to homologous cDNAs previously isolated from ray and rat libraries. A conspicuous difference is an insertion of 33 bp in chick agrin cDNA, which endows the encoded protein with AChR/AChE aggregating activity. Homologous transcripts having the 33 bp insertion were detected in the ray CNS, which indicates that an insertion of similar size is conserved in agrin in many, if not all, vertebrate species. Results of in situ hybridization studies and PCR experiments on mRNA isolated from motor neuron-enriched fractions of the spinal cord indicate that, consistent with the agrin hypothesis, motor neurons contain transcripts that code for active agrin.
journal_name
Neuronjournal_title
Neuronauthors
Tsim KW,Ruegg MA,Escher G,Kröger S,McMahan UJdoi
10.1016/0896-6273(92)90089-vsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
677-89issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(92)90089-Vjournal_volume
8pub_type
杂志文章相关文献
NEURON文献大全abstract：:cGMP has long been suspected to play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recording has impeded tests of this hypothesis. In posterior pituitary nerve terminals, nitric oxide enhanced Ca(2+)-activated K+ channel activity by activating guanylate cyclase and PKG. This e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00449-4
更新日期：2001-09-27 00:00:00
abstract：:An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the i...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2019.04.021
更新日期：2019-06-05 00:00:00
abstract：:Intracortical somatosensory interfaces have now entered the clinical domain. Darie et al. explore the implications of research published in Science Translational Medicine by Flesher et al. (2016), discuss how to design such a system given current technology, and question how to effectively communicate with users about...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2017.02.008
更新日期：2017-02-22 00:00:00
abstract：:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.09.052
更新日期：2015-10-21 00:00:00
abstract：:Sexually dimorphic behaviors are likely to involve neural pathways that express the androgen receptor (AR). We have genetically modified the AR locus to visualize dimorphisms in neuronal populations that express AR. Analysis of AR-positive neurons reveals both known dimorphisms in the preoptic area of the hypothalamus...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.07.008
更新日期：2004-08-05 00:00:00
abstract：:Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00179-9
更新日期：2001-01-01 00:00:00
abstract：:The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated. Here, we used the migration of...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.12.006
更新日期：2011-01-13 00:00:00
abstract：:Input comparison is thought to occur in many neuronal circuits, including the hippocampus, where functionally important interactions between the Schaffer collateral and perforant pathways have been hypothesized. We investigated this idea using multisite, whole-cell recordings and Ca2+ imaging and found that properly t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.03.007
更新日期：2009-04-16 00:00:00
abstract：:Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.008
更新日期：2005-07-21 00:00:00
abstract：:To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single uni...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.040
更新日期：2017-08-02 00:00:00
abstract：:In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.10.003
更新日期：2019-10-23 00:00:00
abstract：:Gamma-frequency oscillations (GFOs, >40 Hz) are a general network signature at seizure onset at all stages of development, with possible deleterious consequences in the immature brain. At early developmental stages, the simultaneous occurrence of GFOs in different brain regions suggests the existence of a long-ranging...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.01.026
更新日期：2012-04-12 00:00:00
abstract：:Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90182-5
更新日期：1995-10-01 00:00:00
abstract：:Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.02.029
更新日期：2019-05-08 00:00:00
abstract：:The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.11.024
更新日期：2016-01-06 00:00:00
abstract：:We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)01047-4
更新日期：2002-11-14 00:00:00
abstract：:The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.08.024
更新日期：2015-09-23 00:00:00
abstract：:Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhod...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00092-1
更新日期：2000-10-01 00:00:00
abstract：:Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.03.003
更新日期：2018-04-04 00:00:00
abstract：:The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.01.032
更新日期：2006-03-02 00:00:00
abstract：:Brain function is mediated by neural circuit connectivity, and elucidating the role of connections is aided by techniques to block their output. We developed cell-type-selective, reversible synaptic inhibition tools for mammalian neural circuits by leveraging G protein signaling pathways to suppress synaptic vesicle r...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.008
更新日期：2014-05-21 00:00:00
abstract：:In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.05.021
更新日期：2013-06-05 00:00:00
abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00147-1
更新日期：2000-12-01 00:00:00
abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.024
更新日期：2012-01-26 00:00:00
abstract：:Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90061-u
更新日期：1993-06-01 00:00:00
abstract：:Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and other physiological responses. They are encoded by ten genes, which generate three voltage-gated calcium channel subfamilies: CaV1; CaV2;...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.03.017
更新日期：2018-05-02 00:00:00
abstract：:Functionally distinct types of neurons develop in stereotypical positions in the vertebrate spinal cord. The mechanisms that generate this diversity have been well studied in the ventral and intermediate regions of the spinal cord, while dorsal cells have received less attention. In this issue of Neuron, two papers fo...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(02)00710-9
更新日期：2002-05-16 00:00:00
abstract：:The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.06.030
更新日期：2012-07-26 00:00:00
abstract：:Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain. Surprisingly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis. Here, we identify the SEC4 ortholog RAB3 and it...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.09.015
更新日期：2019-12-18 00:00:00
abstract：:Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance ev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80869-7
更新日期：2000-01-01 00:00:00
