A network state linking motivation and action in the nucleus accumbens.

abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...

journal_title：Neuron

authors： Fruttiger M,Calver AR,Krüger WH,Mudhar HS,Michalovich D,Takakura N,Nishikawa S,Richardson WD

更新日期：1996-12-01 00:00:00

abstract：:Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...

journal_title：Neuron

authors： Koelsch S

更新日期：2018-06-27 00:00:00

abstract：:When faced with a crowded visual scene, observers must selectively attend to behaviorally relevant objects to avoid sensory overload. Often this selection process is guided by prior knowledge of a target-defining feature (e.g., the color red when looking for an apple), which enhances the firing rate of visual neurons ...

journal_title：Neuron

authors： Serences JT,Boynton GM

更新日期：2007-07-19 00:00:00

abstract：:alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of al...

journal_title：Neuron

authors： Krasnoperov VG,Bittner MA,Beavis R,Kuang Y,Salnikow KV,Chepurny OG,Little AR,Plotnikov AN,Wu D,Holz RW,Petrenko AG

更新日期：1997-06-01 00:00:00

abstract：:Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...

journal_title：Neuron

authors： Ache BW,Young JM

更新日期：2005-11-03 00:00:00

abstract：:Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are loca...

journal_title：Neuron

authors： Moran-Rivard L,Kagawa T,Saueressig H,Gross MK,Burrill J,Goulding M

更新日期：2001-02-01 00:00:00

abstract：VIDEO ABSTRACT:Why do people often choose to cooperate when they can better serve their interests by acting selfishly? One potential mechanism is that the anticipation of guilt can motivate cooperative behavior. We utilize a formal model of this process in conjunction with fMRI to identify brain regions that mediate co...

journal_title：Neuron

authors： Chang LJ,Smith A,Dufwenberg M,Sanfey AG

更新日期：2011-05-12 00:00:00

abstract：:Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...

journal_title：Neuron

authors： Higley MJ,Sabatini BL

更新日期：2008-09-25 00:00:00

abstract：:The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...

journal_title：Neuron

authors： Gonzalez-Castillo J,Bandettini PA

更新日期：2015-06-17 00:00:00

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00

abstract：:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...

journal_title：Neuron

authors： Xiong ZQ,McNamara JO

更新日期：2002-09-12 00:00:00

abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...

journal_title：Neuron

authors： Grossmann T,Oberecker R,Koch SP,Friederici AD

更新日期：2010-03-25 00:00:00

abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...

journal_title：Neuron

authors： Davis AF,Bai J,Fasshauer D,Wolowick MJ,Lewis JL,Chapman ER

更新日期：1999-10-01 00:00:00

abstract：:Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation. ...

journal_title：Neuron

authors： Pinheiro EM,Gertler FB

更新日期：2006-09-21 00:00:00

abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...

journal_title：Neuron

authors： Smith AP,Stephan KE,Rugg MD,Dolan RJ

更新日期：2006-02-16 00:00:00

abstract：:We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2017-05-17 00:00:00

abstract：:Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...

journal_title：Neuron

authors： Seabrook TA,Huberman AD

更新日期：2015-06-03 00:00:00

abstract：:Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...

journal_title：Neuron

authors： Stanley DA,Adolphs R

更新日期：2013-10-30 00:00:00

abstract：:The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...

journal_title：Neuron

authors： Shackleford GM,Willert K,Wang J,Varmus HE

更新日期：1993-11-01 00:00:00

abstract：:Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...

journal_title：Neuron

authors： Pribiag H,Lim BK

更新日期：2020-09-23 00:00:00

abstract：:Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...

journal_title：Neuron

authors： Mitchell SJ,Silver RA

更新日期：2003-05-08 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00

abstract：:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...

journal_title：Neuron

authors： George JM,Jin H,Woods WS,Clayton DF

更新日期：1995-08-01 00:00:00

abstract：:We developed a technology (capturing activated neuronal ensembles [CANE]) to label, manipulate, and transsynaptically trace neural circuits that are transiently activated in behavioral contexts with high efficiency and temporal precision. CANE consists of a knockin mouse and engineered viruses designed to specifically...

journal_title：Neuron

authors： Sakurai K,Zhao S,Takatoh J,Rodriguez E,Lu J,Leavitt AD,Fu M,Han BX,Wang F

更新日期：2016-11-23 00:00:00

abstract：:Recent advances in military-funded neurotechnology and novel opportunities for misusing neurodevices show that the problem of dual use is inherent to neuroscience. This paper discusses how the neuroscience community should respond to these dilemmas and delineates a neuroscience-specific biosecurity framework. This neu...

journal_title：Neuron

authors： Ienca M,Jotterand F,Elger BS

更新日期：2018-01-17 00:00:00

abstract：:Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We h...

journal_title：Neuron

authors： Melnick I,Pronchuk N,Cowley MA,Grove KL,Colmers WF

更新日期：2007-12-20 00:00:00

abstract：:Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...

journal_title：Neuron

authors： Dunaevsky A

更新日期：2004-10-14 00:00:00

abstract：:The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...

journal_title：Neuron

authors： Meng Y,Zhang Y,Jia Z

更新日期：2003-07-03 00:00:00

abstract：:It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...

journal_title：Neuron

authors： Cohen Kadosh R,Cohen Kadosh K,Kaas A,Henik A,Goebel R

更新日期：2007-01-18 00:00:00

abstract：:Neuroscientific findings are rarely translated into public policies that improve the health and well-being of people experiencing serious disorders. I advocate here for investment in policymaker-scientist networks dedicated to such translation for a range of diseases. ...

journal_title：Neuron

authors： Humphreys K

更新日期：2019-09-25 00:00:00