Abstract：
:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we examined regional neural activity and specific interactions between brain regions during a contextual memory retrieval task. We independently manipulated emotional context and relevance of retrieved emotional information to task demands. We show that retrieval of emotionally valenced contextual information is associated with enhanced connectivity from hippocampus to amygdala, structures crucially involved with encoding of emotional events. When retrieval of emotional information is relevant to current behavior, amygdala-hippocampal connectivity increases bidirectionally, under modulatory influences from orbitofrontal cortex, a region implicated in representation of affective value and behavioral guidance. Our findings demonstrate that both memory content and behavioral context impact upon large scale neuronal dynamics underlying emotional retrieval.
journal_name
Neuronjournal_title
Neuronauthors
Smith AP,Stephan KE,Rugg MD,Dolan RJdoi
10.1016/j.neuron.2005.12.025subject
Has Abstractpub_date
2006-02-16 00:00:00pages
631-8issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(06)00008-0journal_volume
49pub_type
杂志文章相关文献
NEURON文献大全abstract：:Accumulation of beta-amyloid protein (Abeta) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue of Neuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Abeta levels are directly modulated by neurona...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2005.12.005
更新日期：2005-12-22 00:00:00
abstract：:Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.05.023
更新日期：2008-07-10 00:00:00
abstract：:Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.12.032
更新日期：2009-02-12 00:00:00
abstract：:In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.015
更新日期：2016-04-20 00:00:00
abstract：:Neuroscientific findings are rarely translated into public policies that improve the health and well-being of people experiencing serious disorders. I advocate here for investment in policymaker-scientist networks dedicated to such translation for a range of diseases. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.08.016
更新日期：2019-09-25 00:00:00
abstract：:Humans can easily focus on one speaker in a multi-talker acoustic environment, but how different areas of the human auditory cortex (AC) represent the acoustic components of mixed speech is unknown. We obtained invasive recordings from the primary and nonprimary AC in neurosurgical patients as they listened to multi-t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.09.007
更新日期：2019-12-18 00:00:00
abstract：:Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of the Dp(16) mouse mod...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.09.010
更新日期：2020-12-09 00:00:00
abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00874-2
更新日期：2004-01-22 00:00:00
abstract：:Neuronal microtubules support intracellular transport, facilitate axon growth, and form a basis for neuronal morphology. While microtubules in nonneuronal cells are depolymerized by cold, Ca(2+), or antimitotic drugs, neuronal microtubules are unusually stable. Such stability is important for normal axon growth and ma...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.01.036
更新日期：2013-04-10 00:00:00
abstract：:Structure-function studies have identified key functional motifs in the acetylcholine receptor, including residues that contribute to the ion channel and to the ligand-binding sites. Little is known, however, about determinants of channel gating kinetics. To identify structural correlates of gating, we examined the st...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90424-3
更新日期：1994-12-01 00:00:00
abstract：:We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.07.018
更新日期：2010-08-12 00:00:00
abstract：:The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80600-5
更新日期：1998-10-01 00:00:00
abstract：:The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M II, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protonation regulates this...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90274-h
更新日期：1992-03-01 00:00:00
abstract：:It is well established that the intraparietal sulcus (IPS) plays an important role in the processing and representation of numerical magnitude. Two recent studies by Piazza et al. and Cohen Kadosh et al. published in this issue of Neuron used fMRI adaptation to explore the extent to which parietal number processing is...
journal_title：Neuron
pub_type： 评论,社论,评审
doi：10.1016/j.neuron.2007.01.001
更新日期：2007-01-18 00:00:00
abstract：:In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2008.08.015
更新日期：2008-09-11 00:00:00
abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90170-k
更新日期：1990-09-01 00:00:00
abstract：:Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81095-8
更新日期：1999-02-01 00:00:00
abstract：:Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2017.06.050
更新日期：2017-08-02 00:00:00
abstract：:Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2005.07.001
更新日期：2005-07-21 00:00:00
abstract：:The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80646-7
更新日期：1998-12-01 00:00:00
abstract：:Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90132-8
更新日期：1988-11-01 00:00:00
abstract：:The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2005.06.002
更新日期：2005-06-16 00:00:00
abstract：:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ga...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.021
更新日期：2016-12-07 00:00:00
abstract：:Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor re...
journal_title：Neuron
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuron.2009.10.018
更新日期：2009-12-10 00:00:00
abstract：:In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.046
更新日期：2017-10-11 00:00:00
abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80850-8
更新日期：1999-10-01 00:00:00
abstract：:Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2016.07.031
更新日期：2016-08-03 00:00:00
abstract：:The parietal lobes of nonhuman primates have been well characterized by single neuron recordings, yet clear partitioning of the human parietal lobes has not been clearly demonstrated. An elegant new fMRI study by Simon and colleagues (this issue of Neuron) suggests that parietal cortex does indeed contain dissociable ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00584-6
更新日期：2002-01-31 00:00:00
abstract：:Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunctio...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.06.009
更新日期：2014-07-02 00:00:00
abstract：:Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.07.028
更新日期：2007-09-06 00:00:00
