Notation-dependent and -independent representations of numbers in the parietal lobes.

abstract：:The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we s...

journal_title：Neuron

authors： Pasciuto E,Ahmed T,Wahle T,Gardoni F,D'Andrea L,Pacini L,Jacquemont S,Tassone F,Balschun D,Dotti CG,Callaerts-Vegh Z,D'Hooge R,Müller UC,Di Luca M,De Strooper B,Bagni C

更新日期：2015-07-15 00:00:00

abstract：:alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of...

journal_title：Neuron

authors： Legan PK,Lukashkina VA,Goodyear RJ,Kössi M,Russell IJ,Richardson GP

更新日期：2000-10-01 00:00:00

abstract：:Neuroscience is an exciting and vibrant field, but building an academic career is not always easy. What are critical success indicators? Which tools help talented young neuroscientists conquer the challenges? In this NeuroView, we discuss instruments and steps that can help people progress through the ranks. ...

journal_title：Neuron

authors： Joëls M,Hoogenraad CC,Poirazi P,Di Luca M

更新日期：2015-05-06 00:00:00

abstract：:Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...

journal_title：Neuron

authors： Card JP,Meade RP,Davis LG

更新日期：1988-11-01 00:00:00

abstract：:The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells determines the balance between quiescence and activation of NSCs. ...

journal_title：Neuron

authors： Piatti VC,Schinder AF

更新日期：2018-08-08 00:00:00

abstract：:The spatial distribution of large-scale functional networks on the cerebral cortex differs between individuals and is particularly variable in association networks that are responsible for higher-order cognition. However, it remains unknown how this functional topography evolves in development and supports cognition. ...

journal_title：Neuron

authors： Cui Z,Li H,Xia CH,Larsen B,Adebimpe A,Baum GL,Cieslak M,Gur RE,Gur RC,Moore TM,Oathes DJ,Alexander-Bloch AF,Raznahan A,Roalf DR,Shinohara RT,Wolf DH,Davatzikos C,Bassett DS,Fair DA,Fan Y,Satterthwaite TD

更新日期：2020-04-22 00:00:00

abstract：:Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...

journal_title：Neuron

authors： Mamaligas AA,Ford CP

更新日期：2016-08-03 00:00:00

abstract：:Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...

journal_title：Neuron

authors： Burke KJ Jr,Keeshen CM,Bender KJ

更新日期：2018-09-05 00:00:00

abstract：:Classical patterning molecules that were previously implicated in controlling cell fate choices in the nervous system have recently been shown to play additional roles in axon guidance and synaptogenesis. Bone morphogenetic proteins (BMPs), Sonic hedgehog (Shh), Wnts, and fibroblast growth factors (FGFs) all participa...

journal_title：Neuron

authors： Salie R,Niederkofler V,Arber S

更新日期：2005-01-20 00:00:00

abstract：:Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires e...

journal_title：Neuron

authors： Park S,Park JM,Kim S,Kim JA,Shepherd JD,Smith-Hicks CL,Chowdhury S,Kaufmann W,Kuhl D,Ryazanov AG,Huganir RL,Linden DJ,Worley PF

更新日期：2008-07-10 00:00:00

abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...

journal_title：Neuron

authors： Wolozin B

更新日期：2004-01-08 00:00:00

abstract：:We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...

journal_title：Neuron

authors： Lamprecht R,Farb CR,LeDoux JE

更新日期：2002-11-14 00:00:00

abstract：:We have investigated ubiquitinated paired helical filaments, which produce a proteinaceous smear in SDS-polyacrylamide gel electrophoresis and immunoblotting. The smear consisted largely of the carboxy-terminal portion of tau and ubiquitin. The ubiquitin-targeted protein was identified as tau in paired helical filamen...

journal_title：Neuron

authors： Morishima-Kawashima M,Hasegawa M,Takio K,Suzuki M,Titani K,Ihara Y

更新日期：1993-06-01 00:00:00

abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...

journal_title：Neuron

authors： Lammel S,Ion DI,Roeper J,Malenka RC

更新日期：2011-06-09 00:00:00

abstract：:In nerve terminals, residual Ca(2+) remaining from previous activity can cause facilitation of transmitter release by a mechanism that is still under debate. Here we show that the intracellular Ca(2+) sensitivity of transmitter release at the calyx of Held is largely unchanged during facilitation, which leaves an incr...

journal_title：Neuron

authors： Felmy F,Neher E,Schneggenburger R

更新日期：2003-03-06 00:00:00

abstract：:Cognitive maps are encoded in the hippocampal formation and related regions and range from the spatial to the purely conceptual. Neural mechanisms that encode information into relational structures, up to an arbitrary level of abstraction, may explain such a broad range of representation. Research now indicates that s...

journal_title：Neuron

authors： Schafer M,Schiller D

更新日期：2018-10-24 00:00:00

abstract：:We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same...

journal_title：Neuron

authors： Frank LM,Brown EN,Wilson M

更新日期：2000-07-01 00:00:00

abstract：:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...

journal_title：Neuron

authors： Xiong ZQ,McNamara JO

更新日期：2002-09-12 00:00:00

abstract：:Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched inject...

journal_title：Neuron

authors： Wu CW,Kaas JH

更新日期：2000-12-01 00:00:00

abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...

journal_title：Neuron

authors： Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

更新日期：2003-10-30 00:00:00

abstract：:To advance the understanding of sleep regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep induction by sNPF meets all relevant criteria. Rebound sleep following sleep deprivation is reduced by activation of sNPF neurons, and flies e...

journal_title：Neuron

authors： Shang Y,Donelson NC,Vecsey CG,Guo F,Rosbash M,Griffith LC

更新日期：2013-10-02 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...

journal_title：Neuron

authors： Woolf CJ,Ma Q

更新日期：2007-08-02 00:00:00

abstract：:To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTP in wild-type mice, ...

journal_title：Neuron

authors： Futatsugi A,Kato K,Ogura H,Li ST,Nagata E,Kuwajima G,Tanaka K,Itohara S,Mikoshiba K

更新日期：1999-11-01 00:00:00

abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...

journal_title：Neuron

authors： Fruttiger M,Calver AR,Krüger WH,Mudhar HS,Michalovich D,Takakura N,Nishikawa S,Richardson WD

更新日期：1996-12-01 00:00:00

abstract：:Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...

journal_title：Neuron

authors： Levine JN,Gu Y,Cang J

更新日期：2015-05-20 00:00:00

abstract：:Classic studies of spatial attention assumed that its neural and behavioral effects were continuous over time. Recent behavioral studies have instead revealed that spatial attention leads to alternating periods of heightened or diminished perceptual sensitivity. Yet, the neural basis of these rhythmic fluctuations has...

journal_title：Neuron

authors： Fiebelkorn IC,Pinsk MA,Kastner S

更新日期：2018-08-22 00:00:00

abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...

journal_title：Neuron

authors： Davis AF,Bai J,Fasshauer D,Wolowick MJ,Lewis JL,Chapman ER

更新日期：1999-10-01 00:00:00

abstract：:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...

journal_title：Neuron

authors： Benton R

更新日期：2011-02-10 00:00:00

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00