Abstract：
:We have investigated ubiquitinated paired helical filaments, which produce a proteinaceous smear in SDS-polyacrylamide gel electrophoresis and immunoblotting. The smear consisted largely of the carboxy-terminal portion of tau and ubiquitin. The ubiquitin-targeted protein was identified as tau in paired helical filaments, and the conjugation sites were localized to the microtubule-binding region. Most ubiquitin in paired helical filaments occurred as a monoubiquitinated form, and only a small proportion of ubiquitin formed multiubiquitin chains. There was a ubiquitin-negative smear, in which tau was much less processed in the amino-terminal portion. This strongly suggests that the amino-terminal processing of tau in paired helical filaments precedes its ubiquitination.
journal_name
Neuronjournal_title
Neuronauthors
Morishima-Kawashima M,Hasegawa M,Takio K,Suzuki M,Titani K,Ihara Ydoi
10.1016/0896-6273(93)90063-wsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
1151-60issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(93)90063-Wjournal_volume
10pub_type
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