Ion channels: from conductance to structure.


:In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years but has also been interspersed with sudden jumps of discovery. These leaps have normally been associated with the introduction of a new technical advance or the development of a new biological preparation; therefore, it is quite certain that we have not seen them all.






Bezanilla F




Has Abstract


2008-11-06 00:00:00
















  • Reorganization of striatal inhibitory microcircuits leads to pathological synchrony in the Basal Ganglia.

    abstract::Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...


    pub_type: 评论,杂志文章


    authors: Belujon P,Grace AA

    更新日期:2011-09-08 00:00:00

  • Is top-down control from prefrontal cortex necessary for visual categorization?

    abstract::The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...


    pub_type: 评论,杂志文章


    authors: Buckley MJ,Sigala N

    更新日期:2010-05-27 00:00:00

  • GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex.

    abstract::The development of GABAergic inhibitory circuits is shaped by neural activity, but the underlying mechanisms are unclear. Here, we demonstrate a novel function of GABA in regulating GABAergic innervation in the adolescent brain, when GABA is mainly known as an inhibitory transmitter. Conditional knockdown of the rate-...


    pub_type: 杂志文章


    authors: Chattopadhyaya B,Di Cristo G,Wu CZ,Knott G,Kuhlman S,Fu Y,Palmiter RD,Huang ZJ

    更新日期:2007-06-21 00:00:00

  • Parsing Hippocampal Theta Oscillations by Nested Spectral Components during Spatial Exploration and Memory-Guided Behavior.

    abstract::Theta oscillations reflect rhythmic inputs that continuously converge to the hippocampus during exploratory and memory-guided behavior. The theta-nested operations that organize hippocampal spiking could either occur regularly from one cycle to the next or be tuned on a cycle-by-cycle basis. To resolve this, we identi...


    pub_type: 杂志文章


    authors: Lopes-Dos-Santos V,van de Ven GM,Morley A,Trouche S,Campo-Urriza N,Dupret D

    更新日期:2018-11-21 00:00:00

  • NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus.

    abstract::Brief bath application of N-methyl-D-aspartate (NMDA) to hippocampal slices produces long-term synaptic depression (LTD) in CA1 that is (1) sensitive to postnatal age, (2) saturable, (3) induced postsynaptically, (4) reversible, and (5) not associated with a change in paired pulse facilitation. Chemically induced LTD ...


    pub_type: 杂志文章


    authors: Lee HK,Kameyama K,Huganir RL,Bear MF

    更新日期:1998-11-01 00:00:00

  • ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

    abstract::Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-β (Aβ) metabolism, aggregation, and deposition. Although earlier work suggests that different affinities of apoE isoforms to Aβ...


    pub_type: 杂志文章,评审


    authors: Kanekiyo T,Xu H,Bu G

    更新日期:2014-02-19 00:00:00

  • Olfactory bulb: odor signals put into context.

    abstract::In this issue, Doucette and colleagues demonstrate that information related to whether an odor is currently linked to reward can be observed uniquely in population activity in the olfactory bulb, changing our understanding both of what is coded by the first olfactory relay in the CNS and of how this coding is instanti...


    pub_type: 评论,杂志文章


    authors: Katz DB,Maier JX

    更新日期:2011-03-24 00:00:00

  • Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording.

    abstract::An axon is thought to faithfully conduct action potentials to its terminals. However, many features of the axon and axon terminals, especially at inhibitory synapses, remain unknown. By directly recording from the axon and terminal of a cultured cerebellar Purkinje cell (PC), we demonstrate that low membrane excitabil...


    pub_type: 杂志文章


    authors: Kawaguchi SY,Sakaba T

    更新日期:2015-03-18 00:00:00

  • Closed-loop and activity-guided optogenetic control.

    abstract::Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled ...


    pub_type: 杂志文章,评审


    authors: Grosenick L,Marshel JH,Deisseroth K

    更新日期:2015-04-08 00:00:00

  • Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events.

    abstract::Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...


    pub_type: 杂志文章


    authors: Jadhav SP,Rothschild G,Roumis DK,Frank LM

    更新日期:2016-04-06 00:00:00

  • There and back again: the corticobulbar loop.

    abstract::Feedback is a ubiquitous anatomical feature of sensory processing in vertebrates. In this issue of Neuron, two papers (Boyd et al., 2012, and Markopoulos et al., 2012) analyze the features of feedback from olfactory cortex to olfactory bulb. ...


    pub_type: 评论,杂志文章


    authors: Oswald AM,Urban NN

    更新日期:2012-12-20 00:00:00

  • Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala.

    abstract::Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...


    pub_type: 杂志文章


    authors: Etkin A,Egner T,Peraza DM,Kandel ER,Hirsch J

    更新日期:2006-09-21 00:00:00

  • Uncovering the Genetic Architecture of Major Depression.

    abstract::There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the...


    pub_type: 杂志文章,评审


    authors: McIntosh AM,Sullivan PF,Lewis CM

    更新日期:2019-04-03 00:00:00

  • Melatonin is required for the circadian regulation of sleep.

    abstract::Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism ...


    pub_type: 杂志文章


    authors: Gandhi AV,Mosser EA,Oikonomou G,Prober DA

    更新日期:2015-03-18 00:00:00

  • Regulation of AMPA receptor function by the human memory-associated gene KIBRA.

    abstract::KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PI...


    pub_type: 杂志文章


    authors: Makuch L,Volk L,Anggono V,Johnson RC,Yu Y,Duning K,Kremerskothen J,Xia J,Takamiya K,Huganir RL

    更新日期:2011-09-22 00:00:00

  • Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins.

    abstract::Molecular determinants of Ca2+ channel responsiveness to inhibition by receptor-coupled G proteins were investigated in Xenopus oocytes. The inhibitory response of alpha1B (N-type) channels was much larger than alpha1A (P/Q-type) channels, while alpha1C (L-type) channels were unresponsive. Differences in both degree a...


    pub_type: 杂志文章


    authors: Zhang JF,Ellinor PT,Aldrich RW,Tsien RW

    更新日期:1996-11-01 00:00:00

  • Interferon-gamma promotes cholinergic differentiation of embryonic septal nuclei and adjacent basal forebrain.

    abstract::In cultured rat embryonic septal nuclei with adjacent basal forebrain, murine interferon-gamma (IFN gamma) produces a striking increase in choline acetyltransferase (ChAT) activity and mRNA. The effect of IFN gamma on cholinergic differentiation is more potent in E14 cultures than in older cultures. IFN gamma does not...


    pub_type: 杂志文章


    authors: Jonakait GM,Wei R,Sheng ZL,Hart RP,Ni L

    更新日期:1994-05-01 00:00:00

  • Ion channel voltage sensors: structure, function, and pathophysiology.

    abstract::Voltage-gated ion channels generate electrical signals in species from bacteria to man. Their voltage-sensing modules are responsible for initiation of action potentials and graded membrane potential changes in response to synaptic input and other physiological stimuli. Extensive structure-function studies, structure ...


    pub_type: 杂志文章,评审


    authors: Catterall WA

    更新日期:2010-09-23 00:00:00

  • Muscarinic modulation of sodium current by activation of protein kinase C in rat hippocampal neurons.

    abstract::Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...


    pub_type: 杂志文章


    authors: Cantrell AR,Ma JY,Scheuer T,Catterall WA

    更新日期:1996-05-01 00:00:00

  • Public-private partnership: a new engine for translational research in neurosciences.

    abstract::We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common path...


    pub_type: 杂志文章


    authors: Murphy DG,Goldman M,Loth E,Spooren W

    更新日期:2014-11-05 00:00:00

  • The Emergence of Directional Selectivity in the Visual Motion Pathway of Drosophila.

    abstract::The perception of visual motion is critical for animal navigation, and flies are a prominent model system for exploring this neural computation. In Drosophila, the T4 cells of the medulla are directionally selective and necessary for ON motion behavioral responses. To examine the emergence of directional selectivity, ...


    pub_type: 杂志文章


    authors: Strother JA,Wu ST,Wong AM,Nern A,Rogers EM,Le JQ,Rubin GM,Reiser MB

    更新日期:2017-04-05 00:00:00

  • AMPA receptor tetramerization is mediated by Q/R editing.

    abstract::AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...


    pub_type: 杂志文章


    authors: Greger IH,Khatri L,Kong X,Ziff EB

    更新日期:2003-11-13 00:00:00

  • Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.

    abstract::Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report r...


    pub_type: 杂志文章


    authors: Devor A,Dunn AK,Andermann ML,Ulbert I,Boas DA,Dale AM

    更新日期:2003-07-17 00:00:00

  • Prefrontal-subcortical pathways mediating successful emotion regulation.

    abstract::Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...


    pub_type: 杂志文章


    authors: Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KN

    更新日期:2008-09-25 00:00:00

  • The role of apolipoprotein E in Alzheimer's disease.

    abstract::The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...


    pub_type: 杂志文章,评审


    authors: Kim J,Basak JM,Holtzman DM

    更新日期:2009-08-13 00:00:00

  • The developmental origins of voice processing in the human brain.

    abstract::In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...


    pub_type: 杂志文章


    authors: Grossmann T,Oberecker R,Koch SP,Friederici AD

    更新日期:2010-03-25 00:00:00

  • Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor.

    abstract::To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...


    pub_type: 杂志文章


    authors: Kawaja MD,Gage FH

    更新日期:1991-12-01 00:00:00

  • p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts.

    abstract::The rich functional diversity of the nervous system is founded in the specific connectivity of the underlying neural circuitry. Neurons are often preprogrammed to respond to multiple axon guidance signals because they use sequential guideposts along their pathways, but this necessitates a strict spatiotemporal regulat...


    pub_type: 杂志文章


    authors: Bonanomi D,Valenza F,Chivatakarn O,Sternfeld MJ,Driscoll SP,Aslanian A,Lettieri K,Gullo M,Badaloni A,Lewcock JW,Hunter T,Pfaff SL

    更新日期:2019-05-08 00:00:00

  • Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.

    abstract::Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...


    pub_type: 杂志文章


    authors: Alexander GM,Rogan SC,Abbas AI,Armbruster BN,Pei Y,Allen JA,Nonneman RJ,Hartmann J,Moy SS,Nicolelis MA,McNamara JO,Roth BL

    更新日期:2009-07-16 00:00:00

  • G1 phase regulation, area-specific cell cycle control, and cytoarchitectonics in the primate cortex.

    abstract::We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...


    pub_type: 杂志文章


    authors: Lukaszewicz A,Savatier P,Cortay V,Giroud P,Huissoud C,Berland M,Kennedy H,Dehay C

    更新日期:2005-08-04 00:00:00