Abstract：
:A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neurons accompanies functional changes is less clear. Here, we use two-photon imaging to monitor the fine structure of inhibitory neurons in mouse visual cortex after deprivation induced by retinal lesions. We find that a subset of inhibitory neurons carry dendritic spines, which form glutamatergic synapses. Removal of visual input correlates with a rapid and lasting reduction in the number of inhibitory cell spines. Similar to the effects seen for dendritic spines, the number of inhibitory neuron boutons dropped sharply after retinal lesions. Together, these data suggest that structural changes in inhibitory neurons may precede structural changes in excitatory circuitry, which ultimately result in functional adaptation following sensory deprivation.
journal_name
Neuronjournal_title
Neuronauthors
Keck T,Scheuss V,Jacobsen RI,Wierenga CJ,Eysel UT,Bonhoeffer T,Hübener Mdoi
10.1016/j.neuron.2011.06.034subject
Has Abstractpub_date
2011-09-08 00:00:00pages
869-82issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00564-2journal_volume
71pub_type
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