Abstract:
:The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells determines the balance between quiescence and activation of NSCs.
journal_name
Neuronjournal_title
Neuronauthors
Piatti VC,Schinder AFdoi
10.1016/j.neuron.2018.07.044subject
Has Abstractpub_date
2018-08-08 00:00:00pages
425-427issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30642-1journal_volume
99pub_type
评论,杂志文章相关文献
NEURON文献大全abstract::Voltage-gated calcium channels are well characterized at neuronal somata but less thoroughly understood at the presynaptic terminal where they trigger transmitter release. In order to elucidate how the intrinsic properties of presynaptic calcium channels influence synaptic function, we have made direct recordings of t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81017-x
更新日期:1998-04-01 00:00:00
abstract::Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. U...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.020
更新日期:2017-06-21 00:00:00
abstract::The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.08.024
更新日期:2015-09-23 00:00:00
abstract::To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00682-2
更新日期:2003-10-30 00:00:00
abstract::In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.09.046
更新日期:2017-10-11 00:00:00
abstract::Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.01.003
更新日期:2015-02-18 00:00:00
abstract::We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90238-m
更新日期:1993-01-01 00:00:00
abstract::It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.05.028
更新日期:2017-06-07 00:00:00
abstract::Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in ol...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(02)00780-8
更新日期:2002-07-18 00:00:00
abstract::Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine disease caused by the expansion of a CAG repeat in the androgen receptor (AR) gene. We generated a transgenic mouse model carrying a full-length AR containing 97 CAGs. Three of the five lines showed progressive muscular atrophy and weakness as well as diffus...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00834-6
更新日期:2002-08-29 00:00:00
abstract::Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90061-u
更新日期:1993-06-01 00:00:00
abstract::Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90239-2
更新日期:1995-01-01 00:00:00
abstract::We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, tr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.09.008
更新日期:2015-10-21 00:00:00
abstract::Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90005-5
更新日期:1995-12-01 00:00:00
abstract::We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90025-9
更新日期:1992-10-01 00:00:00
abstract::Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.030
更新日期:2010-04-29 00:00:00
abstract::Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories and their interrelations, timescales, and neural bases. Here we highlight the prospective nature ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.08.030
更新日期:2019-10-09 00:00:00
abstract::Rho GTPases are essential regulators of cytoskeletal reorganization, but how they do so during neuronal morphogenesis in vivo is poorly understood. Here we show that the actin depolymerization factor cofilin is essential for axon growth in Drosophila neurons. Cofilin function in axon growth is inhibited by LIM kinase ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.11.014
更新日期:2004-12-02 00:00:00
abstract::Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting and overcome many limitations of non-viral tracers. Here, we summarize the viruses that have been developed for neural circuit mapping, and we provide a primer...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.07.010
更新日期:2020-09-23 00:00:00
abstract::We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.008
更新日期:2017-05-17 00:00:00
abstract::LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings ar...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(02)00759-6
更新日期:2002-07-03 00:00:00
abstract::Memory abilities differ greatly across individuals. To explore a source of these differences, we characterized the varied strategies people adopt during unconstrained encoding. Participants intentionally encoded object pairs during functional MRI. Principal components analysis applied to a strategy questionnaire revea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.06.006
更新日期:2006-07-20 00:00:00
abstract::Functional neuroimaging uses activity-dependent changes in cerebral blood flow to map brain activity, but the contributions of presynaptic and postsynaptic activity are incompletely understood, as are the underlying cellular pathways. Using intravital multiphoton microscopy, we measured presynaptic activity, postsynap...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.04.029
更新日期:2008-06-26 00:00:00
abstract::The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80965-4
更新日期:1997-10-01 00:00:00
abstract::Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.01.032
更新日期:2012-04-12 00:00:00
abstract::The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.12.004
更新日期:2019-02-06 00:00:00
abstract::Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(01)00380-4
更新日期:2001-08-16 00:00:00
abstract::In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.10.007
更新日期:2020-10-28 00:00:00
abstract::Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical studies demonstrate that plaque prevention is possible; however, the more relevant therapeutic removal of existing plaque has proven elusive. Monoclonal antibodies in development target both soluble and insoluble Aβ peptide. We h...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.10.029
更新日期:2012-12-06 00:00:00
abstract::Sweet and bitter taste distinguishes good food sources from potential toxins, but what happens when these tastants are mixed? In this issue of Neuron, Jeong et al. (2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the res...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.07.038
更新日期:2013-08-21 00:00:00