Abstract:
:LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings are consistent with a role for LIMK-1 in synapse formation and function.
journal_name
Neuronjournal_title
Neuronauthors
Sarmiere PD,Bamburg JRdoi
10.1016/s0896-6273(02)00759-6subject
Has Abstractpub_date
2002-07-03 00:00:00pages
3-5issue
1eissn
0896-6273issn
1097-4199pii
S0896627302007596journal_volume
35pub_type
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