Abstract：
:Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and disease risk. Less is known about the nature, prevalence, and conservation of other potential epigenetic allelic effects in vivo in the mouse and primate brain. Here we devise genomics, in situ hybridization, and mouse genetics strategies to uncover diverse allelic effects in the brain that are not caused by imprinting or genetic variation. We found allelic effects that are developmental stage and cell type specific, that are prevalent in the neonatal brain, and that cause mosaics of monoallelic brain cells that differentially express wild-type and mutant alleles for heterozygous mutations. Finally, we show that diverse non-genetic allelic effects that impact mental illness risk genes exist in the macaque and human brain. Our findings have potential implications for mammalian brain genetics. VIDEO ABSTRACT.
journal_name
Neuronjournal_title
Neuronauthors
Huang WC,Ferris E,Cheng T,Hörndli CS,Gleason K,Tamminga C,Wagner JD,Boucher KM,Christian JL,Gregg Cdoi
10.1016/j.neuron.2017.01.033subject
Has Abstractpub_date
2017-03-08 00:00:00pages
1094-1109.e7issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30057-0journal_volume
93pub_type
杂志文章相关文献
NEURON文献大全abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.02.018
更新日期：2018-03-07 00:00:00
abstract：:Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2005.11.002
更新日期：2005-11-23 00:00:00
abstract：UNLABELLED:Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury. Three months after C5 lateral hemisections, iPSCs survived and differentiated into neurons and glia and extended tens o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.014
更新日期：2014-08-20 00:00:00
abstract：:Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81007-7
更新日期：1998-04-01 00:00:00
abstract：:A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...
journal_title：Neuron
pub_type： 杂志文章,meta分析
doi：10.1016/j.neuron.2017.09.032
更新日期：2017-10-11 00:00:00
abstract：:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.01.026
更新日期：2015-04-22 00:00:00
abstract：:Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90239-2
更新日期：1995-01-01 00:00:00
abstract：:Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.05.027
更新日期：2019-08-07 00:00:00
abstract：:Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.07.004
更新日期：2008-08-28 00:00:00
abstract：:The concept of the CNS as an immune-privileged organ has led to a common misunderstanding that it is not an active immunological organ, guarded from its surroundings by the blood-brain barrier (BBB). Recent advances in this field clearly demonstrate that the CNS is a highly immunologically active organ, with complex i...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.04.005
更新日期：2013-04-24 00:00:00
abstract：:We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.10.006
更新日期：2009-11-12 00:00:00
abstract：:Neuropeptides activate G protein-coupled receptors to acutely modulate cellular excitability and synaptic transmission. However, due to the lack of reagents for precise delivery of peptides within dense brain tissue, the spatiotemporal scale over which neuropeptides act is unknown. To achieve rapid and spatially delim...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.016
更新日期：2012-01-26 00:00:00
abstract：:Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.03.003
更新日期：2015-04-08 00:00:00
abstract：:The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80965-4
更新日期：1997-10-01 00:00:00
abstract：:Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.01.006
更新日期：2008-02-28 00:00:00
abstract：:Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2020.09.006
更新日期：2020-09-23 00:00:00
abstract：:Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2006.08.020
更新日期：2006-09-21 00:00:00
abstract：:To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminus of A beta 1-40, whil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90458-8
更新日期：1994-07-01 00:00:00
abstract：:Basolateral amygdala and orbitofrontal cortex are implicated in cue-outcome learning. In this issue of Neuron, Schoenbaum et al. show that, following basolateral amygdala lesions, cue-selective neurons in orbitofrontal cortex are more sensory driven and less sensitive to the motivational value of an outcome, suggestin...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00525-7
更新日期：2003-08-28 00:00:00
abstract：:Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chime...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90079-7
更新日期：1988-06-01 00:00:00
abstract：:Synaptotagmin-1 and -2 are known Ca(2+) sensors for fast synchronous neurotransmitter release, but the potential Ca(2+)-sensor functions of other synaptotagmins in release remain uncharacterized. We now show that besides synaptotagmin-1 and -2, only synaptotagmin-9 (also called synaptotagmin-5) mediates fast Ca(2+) tr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.05.004
更新日期：2007-05-24 00:00:00
abstract：:The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary mann...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00292-7
更新日期：2003-05-22 00:00:00
abstract：:Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.009
更新日期：2011-04-28 00:00:00
abstract：:We developed a technology (capturing activated neuronal ensembles [CANE]) to label, manipulate, and transsynaptically trace neural circuits that are transiently activated in behavioral contexts with high efficiency and temporal precision. CANE consists of a knockin mouse and engineered viruses designed to specifically...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.015
更新日期：2016-11-23 00:00:00
abstract：:Movements are universally, sometimes frustratingly, variable. When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control. These posit that the principal limit on repeatable performance is neuromusc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.10.034
更新日期：2006-12-21 00:00:00
abstract：:The link between dysregulated serotonergic activity and depression and anxiety disorders is well established, yet the molecular mechanisms underlying these psychopathologies are not fully understood. Here, we explore the role of microRNAs in regulating serotonergic (5HT) neuron activity. To this end, we determined the...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.05.042
更新日期：2014-07-16 00:00:00
abstract：:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.08.007
更新日期：2013-10-16 00:00:00
abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.12.013
更新日期：2009-01-29 00:00:00
abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.05.008
更新日期：2009-06-25 00:00:00
abstract：:As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.10.032
更新日期：2006-12-07 00:00:00
