Abstract：
UNLABELLED:Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury. Three months after C5 lateral hemisections, iPSCs survived and differentiated into neurons and glia and extended tens of thousands of axons from the lesion site over virtually the entire length of the rat CNS. These iPSC-derived axons extended through adult white matter of the injured spinal cord, frequently penetrating gray matter and forming synapses with rat neurons. In turn, host supraspinal motor axons penetrated human iPSC grafts and formed synapses. These findings indicate that intrinsic neuronal mechanisms readily overcome the inhibitory milieu of the adult injured spinal cord to extend many axons over very long distances; these capabilities persist even in neurons reprogrammed from very aged human cells. VIDEO ABSTRACT:
journal_name
Neuronjournal_title
Neuronauthors
Lu P,Woodruff G,Wang Y,Graham L,Hunt M,Wu D,Boehle E,Ahmad R,Poplawski G,Brock J,Goldstein LS,Tuszynski MHdoi
10.1016/j.neuron.2014.07.014subject
Has Abstractpub_date
2014-08-20 00:00:00pages
789-96issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00625-4journal_volume
83pub_type
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