Abstract：
:Neural representations of head direction (HD) have been discovered in many species. Theoretical work has proposed that the dynamics associated with these representations are generated, maintained, and updated by recurrent network structures called ring attractors. We evaluated this theorized structure-function relationship by performing electron-microscopy-based circuit reconstruction and RNA profiling of identified cell types in the HD system of Drosophila melanogaster. We identified motifs that have been hypothesized to maintain the HD representation in darkness, update it when the animal turns, and tether it to visual cues. Functional studies provided support for the proposed roles of individual excitatory or inhibitory circuit elements in shaping activity. We also discovered recurrent connections between neuronal arbors with mixed pre- and postsynaptic specializations. Our results confirm that the Drosophila HD network contains the core components of a ring attractor while also revealing unpredicted structural features that might enhance the network's computational power.
journal_name
Neuronjournal_title
Neuronauthors
Turner-Evans DB,Jensen KT,Ali S,Paterson T,Sheridan A,Ray RP,Wolff T,Lauritzen JS,Rubin GM,Bock DD,Jayaraman Vdoi
10.1016/j.neuron.2020.08.006subject
Has Abstractpub_date
2020-10-14 00:00:00pages
145-163.e10issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30613-9journal_volume
108pub_type
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