Abstract:
:Backpropagating action potentials (bAPs) are an important signal for associative synaptic plasticity in many neurons, but they often fail to fully invade distal dendrites. In this issue of Neuron, Sjöström and Häusser show that distal propagation failure leads to a spatial gradient of Hebbian plasticity in neocortical pyramidal cells. This gradient can be overcome by cooperative distal synaptic input, leading to fundamentally distinct Hebbian learning rules for distal versus proximal synapses.
journal_name
Neuronjournal_title
Neuronauthors
Bender VA,Feldman DEdoi
10.1016/j.neuron.2006.07.003subject
Has Abstractpub_date
2006-07-20 00:00:00pages
153-5issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(06)00514-9journal_volume
51pub_type
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