Abstract:
:Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study showed that the cardiac muscle type was localized mainly at the somata of most neurons. Analysis of mutant cerebella suggested that the skeletal muscle type was present exclusively in Purkinje cells. These results suggest that Ca(2+)-induced Ca2+ release, probably mediated by the cardiac muscle receptor, functions generally in various neurons, whereas depolarization-induced Ca2+ release, probably mediated by the skeletal muscle receptor, functions specifically in Purkinje cells.
journal_name
Neuronjournal_title
Neuronauthors
Kuwajima G,Futatsugi A,Niinobe M,Nakanishi S,Mikoshiba Kdoi
10.1016/0896-6273(92)90071-ksubject
Has Abstractpub_date
1992-12-01 00:00:00pages
1133-42issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(92)90071-Kjournal_volume
9pub_type
杂志文章相关文献
NEURON文献大全abstract::NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.04.015
更新日期:2009-05-28 00:00:00
abstract::Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.011
更新日期:2016-09-21 00:00:00
abstract::The bendless (ben) mutation of Drosophila alters synaptic connectivity between a subset of CNS neurons. Here, we show that ben also causes morphological abnormalities within the visual system, suggesting that ben functions in a number of different developmental processes. We show that the ben gene encodes a protein wh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90182-q
更新日期:1993-08-01 00:00:00
abstract::Traditional studies of neuroanatomical connections require injection of tracer compounds into living brains, then histology of the postmortem tissue. Here, we describe and validate a compound that reveals neuronal connections in vivo, using MRI. The classic anatomical tracer CTB (cholera-toxin subunit-B) was conjugate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.03.010
更新日期:2011-04-28 00:00:00
abstract::Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an exp...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80801-6
更新日期:1999-07-01 00:00:00
abstract::In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.015
更新日期:2016-04-20 00:00:00
abstract::Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.001
更新日期:2016-10-19 00:00:00
abstract::Synaptic homeostasis is a phenomenon that prevents the nervous system from descending into chaos. In this issue of Neuron, Frank et al. overturn the notion that synaptic homeostasis at Drosophila NMJs is a slow developmental process. They report that postsynaptic changes are offset within minutes by a homeostatic incr...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2006.11.006
更新日期:2006-11-22 00:00:00
abstract::The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.012
更新日期:2010-05-27 00:00:00
abstract::The link between dysregulated serotonergic activity and depression and anxiety disorders is well established, yet the molecular mechanisms underlying these psychopathologies are not fully understood. Here, we explore the role of microRNAs in regulating serotonergic (5HT) neuron activity. To this end, we determined the...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.042
更新日期:2014-07-16 00:00:00
abstract::The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we report that mice with a Bmal1 deletion specific to arginine vasopressin (AVP)-producing neurons showed marked lengthening in the free-running period and activity time of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.02.005
更新日期:2015-03-04 00:00:00
abstract::Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.06.014
更新日期:2009-07-16 00:00:00
abstract::Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.011
更新日期:2017-05-17 00:00:00
abstract::Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.001
更新日期:2005-07-21 00:00:00
abstract::Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90159-0
更新日期:1995-09-01 00:00:00
abstract::Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2012.10.021
更新日期:2012-11-08 00:00:00
abstract::Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90182-5
更新日期:1995-10-01 00:00:00
abstract::Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.03.015
更新日期:2011-04-14 00:00:00
abstract::Although pain is defined as a sensory and emotional experience, it is traditionally researched and clinically treated separately from emotion. Conceptual and mechanistic relationships between these constructs highlight the need for better understanding of their bi-directional influences and the value of bridging the p...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.05.024
更新日期:2020-07-08 00:00:00
abstract::Deciding when to exploit what is already known and when to explore new possibilities is crucial for adapting to novel and dynamic environments. Using reinforcement-based decision making, Costa et al. (2019) in this issue of Neuron find that neurons in the amygdala and ventral-striatum differentially signal the benefit...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.07.021
更新日期:2019-08-07 00:00:00
abstract::Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.03.010
更新日期:2007-04-05 00:00:00
abstract::A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.06.034
更新日期:2011-09-08 00:00:00
abstract::We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90025-9
更新日期:1992-10-01 00:00:00
abstract::Serotonin, a neuromodulator at the crayfish neuromuscular junction, regulates neurotransmission without changing intracellular calcium levels. However, the mechanism of this regulation remains unclear. By analysis of synaptic depression using a depletion model and measurement of vesicle recycling using the styryl dye ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80523-1
更新日期:1998-07-01 00:00:00
abstract::The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result from nigrostriatal deg...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.021
更新日期:2005-08-18 00:00:00
abstract::The Drosophila Dscams are immunoglobulin superfamily members produced from a single gene that is diversified by alternative splicing to produce a family of cell-surface proteins with over 19,000 different ectodomain isoforms. Dscams are critical for neuronal wiring, and mounting evidence suggests that they play a key ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.024
更新日期:2007-10-04 00:00:00
abstract::It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.05.028
更新日期:2017-06-07 00:00:00
abstract::The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endoc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.06.010
更新日期:2009-07-30 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.02.008
更新日期:2008-04-24 00:00:00
abstract::Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca(2+) imaging in cells expressing the gene...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.12.003
更新日期:2012-12-20 00:00:00