Abstract:
:Serotonin, a neuromodulator at the crayfish neuromuscular junction, regulates neurotransmission without changing intracellular calcium levels. However, the mechanism of this regulation remains unclear. By analysis of synaptic depression using a depletion model and measurement of vesicle recycling using the styryl dye FM1-43, we show that serotonin increases the number of vesicles available for transmitter release (total synaptic vesicle pool size). This regulation is due either to an increase in the number of vesicles at each release site or to an activation of previously nonsecreting or silent synapses. We also observed that low calcium medium rendered part of the vesicle pool unavailable for release. These results suggest a new mechanism for regulating synaptic transmission.
journal_name
Neuronjournal_title
Neuronauthors
Wang C,Zucker RSdoi
10.1016/s0896-6273(00)80523-1subject
Has Abstractpub_date
1998-07-01 00:00:00pages
155-67issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80523-1journal_volume
21pub_type
杂志文章相关文献
NEURON文献大全abstract::Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.07.029
更新日期:2006-09-21 00:00:00
abstract::Hundreds of G protein-coupled receptors (GPCRs) and at least six GPCR kinases have been identified, but the only GPCR phosphatase that has been definitively demonstrated is the rhodopsin phosphatase encoded by the rdgC locus of Drosophila. Mutations in rdgC result in defects in termination of the light response and ca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00538-4
更新日期:2001-12-20 00:00:00
abstract::The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary mann...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00292-7
更新日期:2003-05-22 00:00:00
abstract::In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00217-x
更新日期:2004-05-13 00:00:00
abstract::Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...
journal_title:Neuron
pub_type: 评论,社论,评审
doi:10.1016/s0896-6273(02)00664-5
更新日期:2002-04-11 00:00:00
abstract::Antibodies were raised to three portions of the predicted sequences of Shaker, a gene that encodes a family of K+ channel components that are produced by the alternative splicing of transcripts. On immunoblots, the protein products appear to be 65,000-85,000 daltons in size. No smaller products were detected. Immunocy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90448-o
更新日期:1990-01-01 00:00:00
abstract::How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2011.05.005
更新日期:2011-05-26 00:00:00
abstract::Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90081-p
更新日期:1990-10-01 00:00:00
abstract::To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.009
更新日期:2007-11-21 00:00:00
abstract::Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.03.017
更新日期:2012-06-07 00:00:00
abstract::Memory encoding and retrieval require directional exchange of information between different areas in the medial temporal lobe. In this issue of Neuron, Koster et al. (2018) use high-resolution fMRI combined with state-of-the-art data analysis methods to trace the information flow in memory circuits in hippocampus and ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.09.004
更新日期:2018-09-19 00:00:00
abstract::Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...
journal_title:Neuron
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuron.2013.10.032
更新日期:2013-10-30 00:00:00
abstract::Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01132-7
更新日期:2002-12-19 00:00:00
abstract::Autism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have been tested in ASD, but only limited success has been achieved. Here we report that BTBR T(+)Itpr3(tf)/J (BTBR) mice, a model of idiopathic autism, have reduced...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.01.016
更新日期:2014-03-19 00:00:00
abstract::The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.10.008
更新日期:2018-12-05 00:00:00
abstract::In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.029
更新日期:2010-06-10 00:00:00
abstract::The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00368-4
更新日期:2003-07-03 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00394-4
更新日期:2001-08-30 00:00:00
abstract::A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.04.003
更新日期:2007-04-19 00:00:00
abstract::Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.07.019
更新日期:2018-07-25 00:00:00
abstract::Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.08.015
更新日期:2013-11-20 00:00:00
abstract::Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80053-7
更新日期:1996-02-01 00:00:00
abstract::Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.05.039
更新日期:2015-06-03 00:00:00
abstract::Functional neuroimaging uses activity-dependent changes in cerebral blood flow to map brain activity, but the contributions of presynaptic and postsynaptic activity are incompletely understood, as are the underlying cellular pathways. Using intravital multiphoton microscopy, we measured presynaptic activity, postsynap...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.04.029
更新日期:2008-06-26 00:00:00
abstract::GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81044-2
更新日期:1999-12-01 00:00:00
abstract::Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00645-1
更新日期:2002-04-11 00:00:00
abstract::Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities....
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00404-4
更新日期:2001-08-30 00:00:00
abstract::SCA1, a fatal neurodegenerative disorder, is caused by a CAG expansion encoding a polyglutamine stretch in the protein ATXN1. We used RNA sequencing to profile cerebellar gene expression in Pcp2-ATXN1[82Q] mice with ataxia and progressive pathology and Pcp2-ATXN1[30Q]D776 animals having ataxia in absence of Purkinje c...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.02.011
更新日期:2016-03-16 00:00:00
abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00424-x
更新日期:2001-09-13 00:00:00
abstract::While there are selective regions of occipitotemporal cortex that respond to faces, letters, and bodies, the large-scale neural organization of most object categories remains unknown. Here, we find that object representations can be differentiated along the ventral temporal cortex by their real-world size. In a functi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.04.036
更新日期:2012-06-21 00:00:00