Abstract:
:How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th) century, DNA labeling and histo- and immunohistochemistry helped to distinguish the subtypes of dividing cells and delineate their locations in the ventricular and subventricular zones. Recently, genetic and cell biological methods have provided insights into sequential gene expression and molecular and cellular interactions that generate heterogeneous populations of NSCs leading to specific neuronal classes. This precisely regulated developmental process does not tolerate significant in vivo deviation, making replacement of adult neurons by NSCs during pathology a colossal challenge. In contrast, utilizing the trophic factors emanating from the NSC or their derivatives to slow down deterioration or prevent death of degenerating neurons may be a more feasible strategy.
journal_name
Neuronjournal_title
Neuronauthors
Breunig JJ,Haydar TF,Rakic Pdoi
10.1016/j.neuron.2011.05.005subject
Has Abstractpub_date
2011-05-26 00:00:00pages
614-25issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00383-7journal_volume
70pub_type
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