Abstract:
:Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities. Sweet compounds may be distinguished through differential expression of sweet receptors. Novel heterologous expression systems to test bitter and sweet modalities now provide the tools necessary for understanding taste coding.
journal_name
Neuronjournal_title
Neuronauthors
Lewcock JW,Reed RRdoi
10.1016/s0896-6273(01)00404-4subject
Has Abstractpub_date
2001-08-30 00:00:00pages
515-7issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00404-4journal_volume
31pub_type
杂志文章,评审相关文献
NEURON文献大全abstract::Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90180-8
更新日期:1991-05-01 00:00:00
abstract::Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.025
更新日期:2018-11-21 00:00:00
abstract::Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.12.018
更新日期:2008-01-10 00:00:00
abstract::Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.027
更新日期:2017-01-04 00:00:00
abstract::Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90087-v
更新日期:1990-10-01 00:00:00
abstract::Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.10.007
更新日期:2010-10-21 00:00:00
abstract::Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery. Recent studie...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.10.001
更新日期:2017-12-06 00:00:00
abstract::Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.042
更新日期:2020-01-08 00:00:00
abstract::Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.06.041
更新日期:2013-09-04 00:00:00
abstract::Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals....
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00726-8
更新日期:2003-11-13 00:00:00
abstract::Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 l...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2004.12.007
更新日期:2004-12-16 00:00:00
abstract::The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.07.023
更新日期:2006-10-19 00:00:00
abstract::In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.06.018
更新日期:2010-07-29 00:00:00
abstract::Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.05.042
更新日期:2016-07-20 00:00:00
abstract::The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.10.043
更新日期:2015-12-02 00:00:00
abstract::People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.09.022
更新日期:2015-10-07 00:00:00
abstract::Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.12.029
更新日期:2016-02-17 00:00:00
abstract::The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90107-q
更新日期:1990-04-01 00:00:00
abstract::We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.10.006
更新日期:2009-11-12 00:00:00
abstract::Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.03.017
更新日期:2012-06-07 00:00:00
abstract::Depending on the arousal state, neuronal networks display discrete activity patterns that profoundly affect information processing in the brain. In this issue of Neuron, Kurotani et al. report bidirectional modification of inhibition by oscillatory patterns in the neocortex; a mechanism likely to control the impact of...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.03.010
更新日期:2008-03-27 00:00:00
abstract::The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.04.024
更新日期:2005-06-02 00:00:00
abstract::Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computat...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2006.02.010
更新日期:2006-03-02 00:00:00
abstract::Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an ea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.11.033
更新日期:2016-01-06 00:00:00
abstract::In this issue of Neuron, Ajemian et al. present a computational model of the activity of neurons in primary motor cortex (M1) during isometric movements in different postures. By modeling the output of M1 neurons in terms of their influence on muscles, they find each M1 neuron maps its output into a particular pattern...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2008.04.022
更新日期:2008-05-08 00:00:00
abstract::The ability of a neuronal surface glycoprotein to mediate the formation of neuronal connections was tested in an explant culture system. A monoclonal antibody against the limbic system-associated membrane protein (LAMP) was used in co-cultures containing cholinergic neurons of the septum and their hippocampal target n...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90265-1
更新日期:1989-11-01 00:00:00
abstract::How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition? ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.07.033
更新日期:2019-08-21 00:00:00
abstract::Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.12.026
更新日期:2006-02-02 00:00:00
abstract::Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.12.015
更新日期:2020-03-18 00:00:00
abstract::The bendless (ben) mutation of Drosophila alters synaptic connectivity between a subset of CNS neurons. Here, we show that ben also causes morphological abnormalities within the visual system, suggesting that ben functions in a number of different developmental processes. We show that the ben gene encodes a protein wh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90182-q
更新日期:1993-08-01 00:00:00