Abstract：
:Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typical studies that construct a phenomenological model and test whether it reproduces select aspects of neuronal data, we directly fit the synaptic connectivity of an oculomotor memory circuit to a broad range of anatomical, electrophysiological, and behavioral data. Simultaneous fits to all data, combined with sensitivity analyses, revealed complementary roles of synaptic and neuronal recruitment thresholds in providing the nonlinear interactions required to generate the observed circuit behavior. This work provides a methodology for identifying the cellular and synaptic mechanisms underlying short-term memory and demonstrates how the anatomical structure of a circuit may belie its functional organization.
journal_name
Neuronjournal_title
Neuronauthors
Fisher D,Olasagasti I,Tank DW,Aksay ER,Goldman MSdoi
10.1016/j.neuron.2013.06.041subject
Has Abstractpub_date
2013-09-04 00:00:00pages
987-1000issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00557-6journal_volume
79pub_type
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