Abstract：
:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligand is needed to reduce binding to the high-affinity receptor by 50%, but that the same concentrations of BDNF and NGF similarly reduce the binding of either ligand to the low-affinity receptor. Results obtained with cells transfected with the low-affinity NGF receptor gene indicate that these cells bind BDNF, in addition to NGF, whereas cells before transfection do not. These data indicate that the low-affinity NGF receptor is also a low-affinity BDNF receptor and that whatever is conferring high-affinity binding and biological response also considerably reinforces the ability of the low-affinity receptor to discriminate between NGF and BDNF.
journal_name
Neuronjournal_title
Neuronauthors
Rodriguez-Tébar A,Dechant G,Barde YAdoi
10.1016/0896-6273(90)90107-qsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
487-92issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(90)90107-Qjournal_volume
4pub_type
杂志文章相关文献
NEURON文献大全abstract：:Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.05.005
更新日期：2016-06-15 00:00:00
abstract：:When learning to achieve a goal through a complex series of actions, humans often group several actions into a subroutine and evaluate whether the subroutine achieved a specific subgoal. A new study reports brain responses consistent with such "hierarchical reinforcement learning." ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.07.004
更新日期：2011-07-28 00:00:00
abstract：:In this issue of Neuron,Lin et al. (2015) report an optical method to precisely manipulate the activity of GABAA receptors by designing a mutant receptor that binds photosensitive compounds. This allows for studying GABAA receptors in situ and represents a valuable tool to investigate how inhibition affects brain phys...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2015.11.014
更新日期：2015-12-02 00:00:00
abstract：:Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including lear...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.08.032
更新日期：2011-10-20 00:00:00
abstract：:The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin's effects on stimulating the sympathetic nervous system. We found that leptin activates n...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80656-x
更新日期：1998-12-01 00:00:00
abstract：:Music can be seen as a model system for understanding gene × environment interactions and how these can influence neurocognitive development. The concept of musicality, however, is underspecified and not well understood. Here, I propose a framework for defining musicality to provide a foundation for studying the contr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.01.017
更新日期：2012-02-23 00:00:00
abstract：:Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives rise to balanced network dynamics is unknown. Here, we continuously monitored the statistics of network spiking in visual cortical circuits in freely behaving rats for 9 days. Under control conditions in light and dark, networks...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.08.031
更新日期：2019-11-20 00:00:00
abstract：:The targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90310-0
更新日期：1995-03-01 00:00:00
abstract：:Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.12.015
更新日期：2020-03-18 00:00:00
abstract：:Brain areas in the frontal lobe have been implicated in behavioral flexibility and control. The study by Johnston et al. in this issue of Neuron provides novel insights into the roles of the prefrontal and anterior cingulate cortices in controlling behavior. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2007.01.015
更新日期：2007-02-01 00:00:00
abstract：:Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2004.09.006
更新日期：2004-09-30 00:00:00
abstract：:Asymmetric Ca(2+) elevations across the axonal growth cone mediate its turning responses to attractive and repulsive guidance cues. Here we show that clathrin-mediated endocytosis acts downstream of Ca(2+) signals as driving machinery for growth cone turning. In dorsal root ganglion neurons, the formation of clathrin-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.04.007
更新日期：2010-05-13 00:00:00
abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.11.030
更新日期：2010-12-22 00:00:00
abstract：:Cortical plasticity is thought to be important for the establishment, consolidation, and retrieval of permanent memory. Hippocampal long-term potentiation (LTP), a cellular mechanism of learning and memory, requires the activation of glutamate N-methyl-D-aspartate (NMDA) receptors. In particular, it has been suggested...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.08.014
更新日期：2005-09-15 00:00:00
abstract：:Using electrical acupuncture, Liu et al. show how electrical stimulation of primary somatosensory neurons at different body regions can tap into discreet autonomic circuits and, depending on the parameters, initiate either a pro- or anti-inflammatory response. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2020.09.026
更新日期：2020-11-11 00:00:00
abstract：:GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we de...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.043
更新日期：2017-01-18 00:00:00
abstract：:We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden. We combined data from 5,745 cases and 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 cas...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.04.022
更新日期：2015-06-03 00:00:00
abstract：:Fear is a graded central motive state ranging from mild to intense. As threat intensity increases, fear transitions from discriminative to generalized. The circuit mechanisms that process threats of different intensity are not well resolved. Here, we isolate a unique population of locally projecting neurons in the cen...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.034
更新日期：2017-01-04 00:00:00
abstract：:Pletikos et al. (2014) demonstrate in this issue of Neuron that the human neocortex has an "hourglass" temporal gene expression pattern with robust and dynamic transcriptome differences during the prenatal and adolescent/adult periods. Similar changes are not observed in the nonhuman primate-is this what makes us huma...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.01.006
更新日期：2014-01-22 00:00:00
abstract：:Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)01132-7
更新日期：2002-12-19 00:00:00
abstract：:Protein scaffolds are essential for specific and efficient downstream signaling at synapses. Though nicotinic receptors are widely expressed in the nervous system and influence numerous cellular events due in part to their calcium permeability, no scaffolds have yet been identified for the receptors in neurons. Here w...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00324-6
更新日期：2003-06-05 00:00:00
abstract：:The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.08.002
更新日期：2015-09-02 00:00:00
abstract：:Virally based transsynaptic tracing technologies are powerful experimental tools for neuronal circuit mapping. The glycoprotein-deletion variant of the SAD-B19 vaccine strain rabies virus (RABV) has been the reagent of choice in monosynaptic tracing, since it permits the mapping of synaptic inputs to genetically marke...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.01.004
更新日期：2016-02-17 00:00:00
abstract：:Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.009
更新日期：2011-04-28 00:00:00
abstract：:Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.06.027
更新日期：2016-08-03 00:00:00
abstract：:Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.036
更新日期：2014-06-18 00:00:00
abstract：:Real-time activity measurements of genetically identified neuroendocrine vasopressin neurons show they can anticipate osmotic challenges. In this issue of Neuron, Mandelblat-Cerf et al. (2017) show that correlating these results with ongoing behavior and plasma osmolality points to the existence of brain networks that...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.033
更新日期：2017-01-04 00:00:00
abstract：:We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)01128-5
更新日期：2003-01-09 00:00:00
abstract：:Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90248-8
更新日期：1994-10-01 00:00:00
abstract：:The online maintenance and manipulation of information in working memory (WM) is essential for guiding behavior based on our goals. Understanding how WM alters sensory processing in pursuit of different behavioral objectives is therefore crucial to establish the neural basis of our goal-directed behavior. Here we show...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.01.012
更新日期：2018-02-21 00:00:00
