Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance.

Abstract:

:Asymmetric Ca(2+) elevations across the axonal growth cone mediate its turning responses to attractive and repulsive guidance cues. Here we show that clathrin-mediated endocytosis acts downstream of Ca(2+) signals as driving machinery for growth cone turning. In dorsal root ganglion neurons, the formation of clathrin-coated pits is facilitated asymmetrically across the growth cone by a directionally applied chemorepellent, semaphorin 3A, or by Ca(2+) signals that mediate repulsive guidance. In contrast, coated pit formation remains symmetric in the presence of attractive Ca(2+) signals. Inhibition of clathrin-mediated endocytosis abolishes growth cone repulsion, but not attraction, induced by Ca(2+) or extracellular physiological cues. Furthermore, asymmetric perturbation of the balance of endocytosis and exocytosis in the growth cone is sufficient to initiate its turning toward the side with less endocytosis or more exocytosis. With our previous finding that growth cone attraction involves asymmetric exocytosis, we propose that the balance between membrane addition and removal dictates bidirectional axon guidance.

journal_name

Neuron

journal_title

Neuron

authors

Tojima T,Itofusa R,Kamiguchi H

doi

10.1016/j.neuron.2010.04.007

subject

Has Abstract

pub_date

2010-05-13 00:00:00

pages

370-7

issue

3

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(10)00247-3

journal_volume

66

pub_type

杂志文章

相关文献

NEURON文献大全
  • Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop.

    abstract::Neurons propagate information through circuits by integrating thousands of synaptic inputs to generate an action potential output. Inputs from different origins are often targeted to distinct regions of a neuron's dendritic tree, with synapses on more distal dendrites normally having a weaker influence on cellular out...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2010.04.013

    authors: Chevaleyre V,Siegelbaum SA

    更新日期:2010-05-27 00:00:00

  • NRG1 and synaptic function in the CNS.

    abstract::Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS synaptic transmission and circuitry is not well understood. In this issue of Neuron, studies from Li et al. and Woo et al. show that NRG1 and erbB4 regulate transmis...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2007.05.009

    authors: Fischbach GD

    更新日期:2007-05-24 00:00:00

  • Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.

    abstract::Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcome this challenge we have generated genetically restricted recombinase...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.10.028

    authors: Witten IB,Steinberg EE,Lee SY,Davidson TJ,Zalocusky KA,Brodsky M,Yizhar O,Cho SL,Gong S,Ramakrishnan C,Stuber GD,Tye KM,Janak PH,Deisseroth K

    更新日期:2011-12-08 00:00:00

  • NPAS1 represses the generation of specific subtypes of cortical interneurons.

    abstract::Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.10.040

    authors: Stanco A,Pla R,Vogt D,Chen Y,Mandal S,Walker J,Hunt RF,Lindtner S,Erdman CA,Pieper AA,Hamilton SP,Xu D,Baraban SC,Rubenstein JL

    更新日期:2014-12-03 00:00:00

  • Heterogeneity of functional synaptic parameters among single release sites.

    abstract::Following alpha-latrotoxin application to cerebellar slices, bursts of miniature IPSCs (mIPSCs) were observed in interneurons of the molecular layer. Within bursts, mIPSCs had homogeneous amplitudes with a narrow Gaussian distribution. Analysis of successive event amplitudes revealed an interaction between consecutive...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80354-2

    authors: Auger C,Marty A

    更新日期:1997-07-01 00:00:00

  • Blockade of ion channel expression in Xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAs.

    abstract::Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90153-5

    authors: Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

    更新日期:1988-12-01 00:00:00

  • Cascaded effects of spatial adaptation in the early visual system.

    abstract::Virtually all stages of the visual system exhibit adaptation: neurons adjust their responses based on the recent stimulus history. While some of these adjustments occur at specific stages, others may be inherited from earlier stages. How do adaptation effects cascade along the visual system? We measured spatially sele...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.11.025

    authors: Dhruv NT,Carandini M

    更新日期:2014-02-05 00:00:00

  • Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology.

    abstract::In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2015.01.021

    authors: Michaud JP,Rivest S

    更新日期:2015-02-04 00:00:00

  • Neuroligins determine synapse maturation and function.

    abstract::Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.09.003

    authors: Varoqueaux F,Aramuni G,Rawson RL,Mohrmann R,Missler M,Gottmann K,Zhang W,Südhof TC,Brose N

    更新日期:2006-09-21 00:00:00

  • Imaging Exocytosis of Single Synaptic Vesicles at a Fast CNS Presynaptic Terminal.

    abstract::Synaptic vesicles are tethered to the active zone where they are docked/primed so that they can fuse rapidly upon Ca(2+) influx. To directly study these steps at a CNS presynaptic terminal, we used total internal reflection fluorescence (TIRF) microscopy at the live isolated calyx of Held terminal and measured the mov...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.09.047

    authors: Midorikawa M,Sakaba T

    更新日期:2015-11-04 00:00:00

  • The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development.

    abstract::We recently proposed that ciliary neurotrophic factor (CNTF) shares two receptor components with a generally acting cytokine, leukemia inhibitory factor (LIF), but that CNTF also requires a third receptor component (CNTFR alpha) that is mostly restricted to the nervous system in its expression. Here we demonstrate tha...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(93)90245-m

    authors: Ip NY,McClain J,Barrezueta NX,Aldrich TH,Pan L,Li Y,Wiegand SJ,Friedman B,Davis S,Yancopoulos GD

    更新日期:1993-01-01 00:00:00

  • Inference in the Brain: Statistics Flowing in Redundant Population Codes.

    abstract::It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2017.05.028

    authors: Pitkow X,Angelaki DE

    更新日期:2017-06-07 00:00:00

  • Spatial hearing in echoic environments: the role of the envelope in owls.

    abstract::In the precedence effect, sounds emanating directly from the source are localized preferentially over their reflections. Although most studies have focused on the delay between the onset of a sound and its echo, humans still experience the precedence effect when this onset delay is removed. We tested in barn owls the ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2010.07.014

    authors: Nelson BS,Takahashi TT

    更新日期:2010-08-26 00:00:00

  • Behavioral and anatomical consequences of early versus late symbol training in macaques.

    abstract::Distinct brain regions, reproducible from one person to the next, are specialized for processing different kinds of human expertise, such as face recognition and reading. Here, we explore the relationship between age of learning, learning ability, and specialized brain structures. Specifically, we ask whether the exis...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.12.022

    authors: Srihasam K,Mandeville JB,Morocz IA,Sullivan KJ,Livingstone MS

    更新日期:2012-02-09 00:00:00

  • Reduction of information redundancy in the ascending auditory pathway.

    abstract::Information processing by a sensory system is reflected in the changes in stimulus representation along its successive processing stages. We measured information content and stimulus-induced redundancy in the neural responses to a set of natural sounds in three successive stations of the auditory pathway-inferior coll...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.06.030

    authors: Chechik G,Anderson MJ,Bar-Yosef O,Young ED,Tishby N,Nelken I

    更新日期:2006-08-03 00:00:00

  • Sweet successes.

    abstract::Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities....

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/s0896-6273(01)00404-4

    authors: Lewcock JW,Reed RR

    更新日期:2001-08-30 00:00:00

  • A molecular rhythm mediating circadian clock output in Drosophila.

    abstract::Analysis of the Drosophila lark gene indicates that it encodes an RNA-binding protein that functions as a regulatory element of the circadian clock output pathway controlling adult eclosion. We now demonstrate that the lark RNA-binding protein oscillates in abundance during the circadian cycle; importantly, the phasin...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80457-2

    authors: McNeil GP,Zhang X,Genova G,Jackson FR

    更新日期:1998-02-01 00:00:00

  • Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons.

    abstract::Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.07.004

    authors: Ambroggi F,Ishikawa A,Fields HL,Nicola SM

    更新日期:2008-08-28 00:00:00

  • Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.

    abstract::Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.10.032

    authors: Taniguchi M,Carreira MB,Smith LN,Zirlin BC,Neve RL,Cowan CW

    更新日期:2012-01-12 00:00:00

  • Sodium channel gating: no margin for error.

    abstract::Voltage-gated Na(+) channels are the workhorses of spike generation and propagation in excitable cells. Mutations in Na(+) channel genes have been identified in disorders causing episodic dysfunction of heart, skeletal muscle, and brain. Lossin and colleagues from Al George's lab report in this issue of Neuron that th...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/s0896-6273(02)00735-3

    authors: Cannon SC

    更新日期:2002-06-13 00:00:00

  • Temporal integration of olfactory perceptual evidence in human orbitofrontal cortex.

    abstract::Given a noisy sensory world, the nervous system integrates perceptual evidence over time to optimize decision-making. Neurophysiological accumulation of sensory information is well-documented in the animal visual system, but how such mechanisms are instantiated in the human brain remains poorly understood. Here we com...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.06.035

    authors: Bowman NE,Kording KP,Gottfried JA

    更新日期:2012-09-06 00:00:00

  • BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease.

    abstract::In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(91)90273-3

    authors: Phillips HS,Hains JM,Armanini M,Laramee GR,Johnson SA,Winslow JW

    更新日期:1991-11-01 00:00:00

  • Under the eye of Nr-CAM.

    abstract::Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that ...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.neuron.2006.05.002

    authors: Nguyen-Ba-Charvet KT,Chédotal A

    更新日期:2006-05-18 00:00:00

  • Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration.

    abstract::Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neuron-specific modulators of caspase signaling have been described. Using a mass...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.05.030

    authors: Hertz NT,Adams EL,Weber RA,Shen RJ,O'Rourke MK,Simon DJ,Zebroski H,Olsen O,Morgan CW,Mileur TR,Hitchcock AM,Sinnott Armstrong NA,Wainberg M,Bassik MC,Molina H,Wells JA,Tessier-Lavigne M

    更新日期:2019-08-07 00:00:00

  • Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events.

    abstract::Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.02.010

    authors: Jadhav SP,Rothschild G,Roumis DK,Frank LM

    更新日期:2016-04-06 00:00:00

  • Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

    abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.04.009

    authors: Nelson AB,Gittis AH,du Lac S

    更新日期:2005-05-19 00:00:00

  • Excitatory and Inhibitory Subnetworks Are Equally Selective during Decision-Making and Emerge Simultaneously during Learning.

    abstract::Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.09.045

    authors: Najafi F,Elsayed GF,Cao R,Pnevmatikakis E,Latham PE,Cunningham JP,Churchland AK

    更新日期:2020-01-08 00:00:00

  • Shunting inhibition modulates neuronal gain during synaptic excitation.

    abstract::Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00200-9

    authors: Mitchell SJ,Silver RA

    更新日期:2003-05-08 00:00:00

  • Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.

    abstract::During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes....

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00586-4

    authors: Plump AS,Erskine L,Sabatier C,Brose K,Epstein CJ,Goodman CS,Mason CA,Tessier-Lavigne M

    更新日期:2002-01-17 00:00:00

  • The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.

    abstract::Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.11.027

    authors: Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

    更新日期:2006-01-05 00:00:00