Abstract:
:The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a large number of studies have been conducted since, each supporting some aspect of each of these theories, until recently integrative evidence for the existence of engram cells and circuits as defined by the theories was lacking. In the past few years, the combination of transgenics, optogenetics, and other technologies has allowed neuroscientists to begin identifying memory engram cells by detecting specific populations of cells activated during specific learning epochs and by engineering them not only to evoke recall of the original memory, but also to alter the content of the memory.
journal_name
Neuronjournal_title
Neuronauthors
Tonegawa S,Liu X,Ramirez S,Redondo Rdoi
10.1016/j.neuron.2015.08.002subject
Has Abstractpub_date
2015-09-02 00:00:00pages
918-31issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00677-7journal_volume
87pub_type
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