Abstract：
:Protein scaffolds are essential for specific and efficient downstream signaling at synapses. Though nicotinic receptors are widely expressed in the nervous system and influence numerous cellular events due in part to their calcium permeability, no scaffolds have yet been identified for the receptors in neurons. Here we show that specific members of the PSD-95 family of PDZ-containing proteins are associated with specific nicotinic receptor subtypes. At postsynaptic sites, the PDZ scaffolds are essential for maturation of functional nicotinic synapses on neurons. They also help mediate downstream signaling as exemplified by activation of transcription factors. By tethering components to postsynaptic nicotinic receptors, PDZ scaffolds can organize synaptic structure and determine which calcium-dependent processes will be subject to nicotinic modulation.
journal_name
Neuronjournal_title
Neuronauthors
Conroy WG,Liu Z,Nai Q,Coggan JS,Berg DKdoi
10.1016/s0896-6273(03)00324-6subject
Has Abstractpub_date
2003-06-05 00:00:00pages
759-71issue
5eissn
0896-6273issn
1097-4199pii
S0896627303003246journal_volume
38pub_type
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