Abstract：
:The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction.
journal_name
Neuronjournal_title
Neuronauthors
Hippenmeyer S,Shneider NA,Birchmeier C,Burden SJ,Jessell TM,Arber Sdoi
10.1016/s0896-6273(02)01101-7subject
Has Abstractpub_date
2002-12-19 00:00:00pages
1035-49issue
6eissn
0896-6273issn
1097-4199pii
S0896627302011017journal_volume
36pub_type
杂志文章相关文献
NEURON文献大全abstract：:The bendless (ben) mutation of Drosophila alters synaptic connectivity between a subset of CNS neurons. Here, we show that ben also causes morphological abnormalities within the visual system, suggesting that ben functions in a number of different developmental processes. We show that the ben gene encodes a protein wh...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90182-q
更新日期：1993-08-01 00:00:00
abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.04.035
更新日期：2013-06-19 00:00:00
abstract：UNLABELLED:Developmental dyslexia is a reading disorder, yet deficits also manifest in the magnocellular-dominated dorsal visual system. Uncertainty about whether visual deficits are causal or consequential to reading disability encumbers accurate identification and appropriate treatment of this common learning disabil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.002
更新日期：2013-07-10 00:00:00
abstract：:Memory enables flexible use of past experience to inform new behaviors. Although leading theories hypothesize that this fundamental flexibility results from the formation of integrated memory networks relating multiple experiences, the neural mechanisms that support memory integration are not well understood. Here, we...
journal_title：Neuron
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuron.2012.05.010
更新日期：2012-07-12 00:00:00
abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90139-5
更新日期：1992-06-01 00:00:00
abstract：:In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2020.10.007
更新日期：2020-10-28 00:00:00
abstract：:Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...
journal_title：Neuron
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neuron.2013.10.038
更新日期：2013-10-30 00:00:00
abstract：:The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2016.05.012
更新日期：2016-05-18 00:00:00
abstract：:In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.05.021
更新日期：2013-06-05 00:00:00
abstract：:Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin. However, how signal is transduced from agrin to MuSK remains unclear. We report that LRP4, a low-density lipoprotein receptor (LDLR)-related protein, is expre...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.10.006
更新日期：2008-10-23 00:00:00
abstract：:During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes....
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00586-4
更新日期：2002-01-17 00:00:00
abstract：:Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals....
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00726-8
更新日期：2003-11-13 00:00:00
abstract：:The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, neurotransmitter release, and potentiated the size, but not the properties, of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.09.019
更新日期：2009-10-29 00:00:00
abstract：:Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2019.01.039
更新日期：2019-03-06 00:00:00
abstract：:In a recent study in the journal Cell, Tervo et al. (2014) show that animals can implement stochastic choice policies in environments unfavorable to predictive strategies. The shift toward stochastic behavior was driven by noradrenergic signaling in the anterior cingulate cortex. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.09.025
更新日期：2014-10-01 00:00:00
abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.04.024
更新日期：2005-06-02 00:00:00
abstract：:Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ri...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.017
更新日期：2017-09-27 00:00:00
abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2020.01.035
更新日期：2020-02-19 00:00:00
abstract：:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90277-1
更新日期：1994-02-01 00:00:00
abstract：:In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.022
更新日期：2017-09-27 00:00:00
abstract：:Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.08.024
更新日期：2017-09-13 00:00:00
abstract：:We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate dif...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.07.002
更新日期：2007-07-19 00:00:00
abstract：:A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.04.010
更新日期：2013-06-05 00:00:00
abstract：:Cognitive maps are encoded in the hippocampal formation and related regions and range from the spatial to the purely conceptual. Neural mechanisms that encode information into relational structures, up to an arbitrary level of abstraction, may explain such a broad range of representation. Research now indicates that s...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.10.006
更新日期：2018-10-24 00:00:00
abstract：:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.022
更新日期：2017-07-05 00:00:00
abstract：:In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.05.029
更新日期：2010-06-10 00:00:00
abstract：:We measured amygdala activity in human volunteers during rapid visual presentations of fearful, happy, and neutral faces using functional magnetic resonance imaging (fMRI). The first experiment involved a fixed order of conditions both within and across runs, while the second one used a fully counterbalanced order in ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80219-6
更新日期：1996-11-01 00:00:00
abstract：:Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80548-6
更新日期：1998-08-01 00:00:00
abstract：:Antibodies were raised to three portions of the predicted sequences of Shaker, a gene that encodes a family of K+ channel components that are produced by the alternative splicing of transcripts. On immunoblots, the protein products appear to be 65,000-85,000 daltons in size. No smaller products were detected. Immunocy...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90448-o
更新日期：1990-01-01 00:00:00
abstract：:Neurotransmitter release can be synchronous and occur within milliseconds of action potential invasion, or asynchronous and persist for tens of milliseconds. The molecular determinants of release kinetics remain poorly understood. It has been hypothesized that asynchronous release dominates when fast Synaptotagmin iso...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.013
更新日期：2019-03-06 00:00:00
