Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

abstract：:In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...

journal_title：Neuron

authors： Rowland DC,Moser MB

更新日期：2013-06-19 00:00:00

abstract：:Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...

journal_title：Neuron

authors： Thannickal TC,Moore RY,Nienhuis R,Ramanathan L,Gulyani S,Aldrich M,Cornford M,Siegel JM

更新日期：2000-09-01 00:00:00

abstract：:Two mutations in the sodium channel alpha subunit that have been implicated as the cause of periodic paralysis were studied by functional expression in a mammalian cell line. Both mutations disrupted inactivation without affecting the time course of the onset of the sodium current or the single-channel conductance. Th...

journal_title：Neuron

authors： Cannon SC,Strittmatter SM

更新日期：1993-02-01 00:00:00

abstract：:Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...

journal_title：Neuron

authors： Sanders JI,Hangya B,Kepecs A

更新日期：2016-05-04 00:00:00

abstract：:Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...

journal_title：Neuron

authors： Vlasits AL,Bos R,Morrie RD,Fortuny C,Flannery JG,Feller MB,Rivlin-Etzion M

更新日期：2014-09-03 00:00:00

abstract：:The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca(2+) imaging from genetica...

journal_title：Neuron

authors： Pinto L,Dan Y

更新日期：2015-07-15 00:00:00

abstract：:The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...

journal_title：Neuron

authors： Poulsen KT,Armanini MP,Klein RD,Hynes MA,Phillips HS,Rosenthal A

更新日期：1994-11-01 00:00:00

abstract：:Using a transgenic mouse line in which GFP is expressed in a single population of retinal ganglion cells (RGCs), Huberman and colleagues report in this issue of Neuron that the axon terminals of RGCs exhibit an orderly pattern of distribution in the higher visual centers. This pattern undergoes a developmental refinem...

journal_title：Neuron

authors： He S

更新日期：2008-08-14 00:00:00

abstract：:In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined ...

journal_title：Neuron

authors： Phillips HS,Hains JM,Armanini M,Laramee GR,Johnson SA,Winslow JW

更新日期：1991-11-01 00:00:00

abstract：:A multitude of synaptic proteins interact at the active zones of nerve terminals to achieve the high temporal precision of neurotransmitter release in synchrony with action potentials. Though synaptotagmin has been recognized as the Ca2+ sensor for synchronous release, it may have additional roles of action. We addres...

journal_title：Neuron

authors： Young SM Jr,Neher E

更新日期：2009-08-27 00:00:00

abstract：:We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...

journal_title：Neuron

authors： Mashour GA,Roelfsema P,Changeux JP,Dehaene S

更新日期：2020-03-04 00:00:00

abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...

journal_title：Neuron

authors： Wolozin B

更新日期：2004-01-08 00:00:00

abstract：:The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...

journal_title：Neuron

authors： Singh KK,Ge X,Mao Y,Drane L,Meletis K,Samuels BA,Tsai LH

更新日期：2010-07-15 00:00:00

abstract：:We have investigated the specification of noradrenergic neurotransmitter identity in neural crest stem cells (NCSCs). Retroviral expression of both wild-type and dominant-negative forms of the paired homeodomain transcription factor Phox2a indicates a crucial and direct role for this protein (and/or the closely relate...

journal_title：Neuron

authors： Lo L,Morin X,Brunet JF,Anderson DJ

更新日期：1999-04-01 00:00:00

abstract：:Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...

journal_title：Neuron

authors： Tse FW,Tse A,Hille B,Horstmann H,Almers W

更新日期：1997-01-01 00:00:00

abstract：:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

journal_title：Neuron

authors： Vinck M,Batista-Brito R,Knoblich U,Cardin JA

更新日期：2015-05-06 00:00:00

abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...

journal_title：Neuron

authors： McAllister AK,van de Water J

更新日期：2009-10-15 00:00:00

abstract：:We examined the contribution of the amygdala to value signals within orbital prefrontal cortex (OFC) and medial prefrontal cortex (MFC). On each trial, monkeys chose between two stimuli that were associated with different quantities of reward. In intact monkeys, as expected, neurons in both OFC and MFC signaled the re...

journal_title：Neuron

authors： Rudebeck PH,Mitz AR,Chacko RV,Murray EA

更新日期：2013-12-18 00:00:00

abstract：:In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...

journal_title：Neuron

authors： Münte TF,Kutas M

更新日期：2008-09-11 00:00:00

abstract：:Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption of MeCP2 S421 phosph...

journal_title：Neuron

authors： Cohen S,Gabel HW,Hemberg M,Hutchinson AN,Sadacca LA,Ebert DH,Harmin DA,Greenberg RS,Verdine VK,Zhou Z,Wetsel WC,West AE,Greenberg ME

更新日期：2011-10-06 00:00:00

abstract：:During Drosophila visual system development, photoreceptor (R) axons choose their correct paths and targets in a step-wise fashion. R axons with different identities make specific pathfinding decisions at different stages during development. We show here that the transmembrane protein Golden goal (Gogo), which is dyna...

journal_title：Neuron

authors： Tomasi T,Hakeda-Suzuki S,Ohler S,Schleiffer A,Suzuki T

更新日期：2008-03-13 00:00:00

abstract：:DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing and has been studied extensively as a lifelong molecular information storage mechanism put in place during development. Here we report that DNMT gene expr...

journal_title：Neuron

authors： Miller CA,Sweatt JD

更新日期：2007-03-15 00:00:00

abstract：:The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We...

journal_title：Neuron

authors： Yamaguchi T,Danjo T,Pastan I,Hikida T,Nakanishi S

更新日期：2013-05-08 00:00:00

abstract：:The identification of surface proteins restricted to subsets of embryonic axons and growth cones may provide information on the mechanisms underlying axon fasciculation and pathway selection in the vertebrate nervous system. We describe here the characterization of a 135 kd cell surface glycoprotein, TAG-1, that is ex...

journal_title：Neuron

authors： Dodd J,Morton SB,Karagogeos D,Yamamoto M,Jessell TM

更新日期：1988-04-01 00:00:00

abstract：:Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involve...

journal_title：Neuron

authors： Kanold PO,Shatz CJ

更新日期：2006-09-07 00:00:00

abstract：:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...

journal_title：Neuron

authors： Cummings JA,Mulkey RM,Nicoll RA,Malenka RC

更新日期：1996-04-01 00:00:00

abstract：:Traditional studies of neuroanatomical connections require injection of tracer compounds into living brains, then histology of the postmortem tissue. Here, we describe and validate a compound that reveals neuronal connections in vivo, using MRI. The classic anatomical tracer CTB (cholera-toxin subunit-B) was conjugate...

journal_title：Neuron

authors： Wu CW,Vasalatiy O,Liu N,Wu H,Cheal S,Chen DY,Koretsky AP,Griffiths GL,Tootell RB,Ungerleider LG

更新日期：2011-04-28 00:00:00

abstract：:Apart from being a common feature of mental illness, auditory hallucinations provide an intriguing model for the study of internally generated sensory perceptions that are attributed to external sources. Until now, the knowledge about the cortical network that supports such hallucinations has been restricted by method...

journal_title：Neuron

authors： Dierks T,Linden DE,Jandl M,Formisano E,Goebel R,Lanfermann H,Singer W

更新日期：1999-03-01 00:00:00

abstract：:The structural plasticity of dendritic spines is considered to be essential for various forms of synaptic plasticity, learning, and memory. The process is mediated by a complex signaling network consisting of numerous species of molecules. Furthermore, the spatiotemporal dynamics of the biochemical signaling are regul...

journal_title：Neuron

authors： Nishiyama J,Yasuda R

更新日期：2015-07-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles of molecules like BDNF in synaptic plasticity with more molecular specificity than is possible using pharmacological approaches. ...

journal_title：Neuron

authors： Patterson SL,Abel T,Deuel TA,Martin KC,Rose JC,Kandel ER

更新日期：1996-06-01 00:00:00