Abstract:
:We examined the contribution of the amygdala to value signals within orbital prefrontal cortex (OFC) and medial prefrontal cortex (MFC). On each trial, monkeys chose between two stimuli that were associated with different quantities of reward. In intact monkeys, as expected, neurons in both OFC and MFC signaled the reward quantity associated with stimuli. Contrasted with MFC, OFC contained a larger proportion of neurons encoding reward quantity and did so with faster response latencies. Removing the amygdala eliminated these differences, mainly by decreasing value coding in OFC. Similar decreases occurred in OFC immediately before and after reward delivery. Although the amygdala projects to both OFC and MFC, we found that it has its greatest influence over reward-value coding in OFC. Notably, amygdala lesions did not abolish value coding in OFC, which shows that OFC's representations of the value of objects, choices, and outcomes depends, in large part, on other sources.
journal_name
Neuronjournal_title
Neuronauthors
Rudebeck PH,Mitz AR,Chacko RV,Murray EAdoi
10.1016/j.neuron.2013.09.036subject
Has Abstractpub_date
2013-12-18 00:00:00pages
1519-31issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00867-2journal_volume
80pub_type
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