Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity.

Abstract:

:Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large schizophrenia case-control sample (n = 32,143). The voltage-gated cation channel activity gene set, consisting of genes related to neuronal excitability, was robustly linked to performance in working memory-related tasks across ages and to schizophrenia. Functional brain imaging in 707 healthy participants linked this gene set also to working memory-related activity in the parietal cortex and the cerebellum. Gene set analyses may help to dissect the molecular underpinnings of cognitive dimensions, brain activity, and psychopathology.

journal_name

Neuron

journal_title

Neuron

authors

Heck A,Fastenrath M,Ackermann S,Auschra B,Bickel H,Coynel D,Gschwind L,Jessen F,Kaduszkiewicz H,Maier W,Milnik A,Pentzek M,Riedel-Heller SG,Ripke S,Spalek K,Sullivan P,Vogler C,Wagner M,Weyerer S,Wolfsgruber S,de

doi

10.1016/j.neuron.2014.01.010

subject

Has Abstract

pub_date

2014-03-05 00:00:00

pages

1203-1213

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(14)00015-4

journal_volume

81

pub_type

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