Abstract：
:We have devised a simple bioassay for the identification of molecules that inhibit growth cone motility. Chick dorsal root ganglion (DRG) growth cones extending on laminin collapse when exposed to a suspension of embryonic brain membranes. Detergent-solubilized membranes from which the detergent has been removed collapse DRG growth cones extending on either laminin or chick L1. Collapse occurs over a time course of minutes and is fully reversible. Solubilized liver, primary fibroblast, or RN22 schwannoma cell membranes do not collapse DRG or retinal growth cones. Solubilized PC12 membranes cause retinal but not DRG growth cones to collapse. The collapsing activity from embryonic brain is heat-labile, is trypsin-sensitive, and behaves as a macromolecule on a sizing column. It can be enriched 100-fold by chromatography on heparin and hydroxylapatite. These results are consistent with the idea that growth cone motility is inhibited by specific membrane-associated proteins in the developing nervous system.
journal_name
Neuronjournal_title
Neuronauthors
Raper JA,Kapfhammer JPdoi
10.1016/0896-6273(90)90440-qsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
21-9issue
1eissn
0896-6273issn
1097-4199pii
0896-6273(90)90440-Qjournal_volume
4pub_type
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