Abstract:
:Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA receptor regulates receptor trafficking. All AMPA receptor subunits are palmitoylated on two cysteine residues in their transmembrane domain (TMD) 2 and in their C-terminal region. Palmitoylation on TMD 2 is upregulated by the palmitoyl acyl transferase GODZ and leads to an accumulation of the receptor in the Golgi and a reduction of receptor surface expression. C-terminal palmitoylation decreases interaction of the AMPA receptor with the 4.1N protein and regulates AMPA- and NMDA-induced AMPA receptor internalization. Moreover, depalmitoylation of the receptor is regulated by activation of glutamate receptors. These data suggest that regulated palmitoylation of AMPA receptor subunits modulates receptor trafficking and may be important for synaptic plasticity.
journal_name
Neuronjournal_title
Neuronauthors
Hayashi T,Rumbaugh G,Huganir RLdoi
10.1016/j.neuron.2005.06.035subject
Has Abstractpub_date
2005-09-01 00:00:00pages
709-23issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00645-8journal_volume
47pub_type
杂志文章相关文献
NEURON文献大全abstract::Type IIA rat brain Na+ channel alpha subunits were expressed in CHO cells by nuclear microinjection or by transfection using a vector containing both metallothionein and bacteriophage SP6 promoters. Stable cell lines expressing Na+ channels were isolated, and whole-cell Na+ currents of 0.9-14 nA were recorded. The mea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90108-p
更新日期:1992-01-01 00:00:00
abstract::The functional expression of Ca2+-activated K+ channels (KCa) in developing chick ciliary ganglion (CG) neurons requires interactions with target tissues and preganglionic innervation. Here, we show that the stimulatory effects of target tissues are mediated by an isoform of TGFbeta. Exposure of cultured CG neurons to...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80622-4
更新日期:1998-11-01 00:00:00
abstract::Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00200-9
更新日期:2003-05-08 00:00:00
abstract::Sleep has many inherent benefits, including an important role in memory consolidation. In this issue of Neuron, Ngo et al. (2013b) demonstrate that appropriately timed sounds delivered during sleep can invigorate electrophysiological oscillations conducive to memory stabilization. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.04.032
更新日期:2013-05-08 00:00:00
abstract::The role of cellular interactions in determining the fates of two identified motoneurons in the embryonic zebrafish was investigated by transplanting individual motoneurons from labeled donor embryos to unlabeled hosts. The results suggest that although these cells normally adopt different fates, they form an equivale...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90290-t
更新日期:1992-02-01 00:00:00
abstract::To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00682-2
更新日期:2003-10-30 00:00:00
abstract::Long-term, but not short-term, facilitation induced by 5-HT in Aplysia sensory neurons is blocked by application of inhibitors of protein synthesis or RNA synthesis during the 1.5 hr training period. These findings suggest that genes and proteins not needed for the short-term process are required for long-term facilit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90046-9
更新日期:1989-06-01 00:00:00
abstract::Acetylcholinesterase (AChE) density at the neuromuscular junction of frog cutaneous pectoris muscle was determined by electron microscope autoradiography and biochemistry to be approximately 600 sites micron-2 of postsynaptic area, approximately 4-fold lower than all previous reports (mouse), whereas the hydrolytic tu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90331-x
更新日期:1994-04-01 00:00:00
abstract::Voltage-activated potassium (Kv) channels from mammalian brain are hetero-oligomers containing alpha and beta subunits. Coexpression of Kv1 alpha and Kv beta 1 subunits confers rapid A-type inactivation on noninactivating potassium channels (delayed rectifiers) in expression systems in vitro. We have delineated a Kv1....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80063-x
更新日期:1996-02-01 00:00:00
abstract::The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90213-5
更新日期:1994-03-01 00:00:00
abstract::Neurotropic viruses that conditionally infect or replicate in molecularly defined neuronal subpopulations, and then spread transsynaptically, are powerful tools for mapping neural pathways. Genetically targetable retrograde transsynaptic tracer viruses are available to map the inputs to specific neuronal subpopulation...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.12.002
更新日期:2011-12-22 00:00:00
abstract::Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.03.028
更新日期:2015-05-06 00:00:00
abstract::Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study sh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90071-k
更新日期:1992-12-01 00:00:00
abstract::Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00179-9
更新日期:2001-01-01 00:00:00
abstract::The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct spatial distributions underpin diversity of synaptic function is unknown. We performed single bouton Ca2+ imaging, Ca2+ chelator competition, im...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.08.014
更新日期:2019-11-20 00:00:00
abstract::Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.12.012
更新日期:2008-02-07 00:00:00
abstract::Synaptic vesicles are tethered to the active zone where they are docked/primed so that they can fuse rapidly upon Ca(2+) influx. To directly study these steps at a CNS presynaptic terminal, we used total internal reflection fluorescence (TIRF) microscopy at the live isolated calyx of Held terminal and measured the mov...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.09.047
更新日期:2015-11-04 00:00:00
abstract::Dynamic rearrangements of axon terminal arbors may be critical for establishing appropriate connections in the developing nervous system. Here, the changes in complex retinal axon arbors in the tecta of live Xenopus larvae were followed during the formation of the topographic retinotectal projection. Three-dimensional...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90343-3
更新日期:1994-04-01 00:00:00
abstract::The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orienta...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00460-3
更新日期:2001-10-25 00:00:00
abstract::Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.01.022
更新日期:2017-03-08 00:00:00
abstract::The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells determines the balance between quiescence and activation of NSCs. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.07.044
更新日期:2018-08-08 00:00:00
abstract::Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90159-0
更新日期:1995-09-01 00:00:00
abstract::Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.12.010
更新日期:2020-01-22 00:00:00
abstract::How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition? ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.07.033
更新日期:2019-08-21 00:00:00
abstract::Data on neuropsychiatric and behavioral genetics have attracted legal interest, as attorneys explore their use in criminal and civil cases. These developments may assist judges and juries in making difficult judgments-but they bring substantial risk of misinterpretation and misuse. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.026
更新日期:2014-06-04 00:00:00
abstract::Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2017.11.002
更新日期:2017-11-15 00:00:00
abstract::The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00316-6
更新日期:2001-06-01 00:00:00
abstract::Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.01.023
更新日期:2017-02-22 00:00:00
abstract::All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mou...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.08.005
更新日期:2019-11-06 00:00:00
abstract::The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.02.028
更新日期:2005-04-07 00:00:00