Abstract:
:Voltage-activated potassium (Kv) channels from mammalian brain are hetero-oligomers containing alpha and beta subunits. Coexpression of Kv1 alpha and Kv beta 1 subunits confers rapid A-type inactivation on noninactivating potassium channels (delayed rectifiers) in expression systems in vitro. We have delineated a Kv1.5 aminoterminal region of up to 90 amino acids (residues 112-201) that is sufficient for interactions of Kv1.5 alpha and Kv beta 1 subunits. Within this region of the Kv1.5 amino terminus (residues 193-201), a Kv beta 1 interaction site necessary for Kv beta 1-mediated rapid inactivation of Kv1.5 currents was detected. This interaction site motif (FYE/QLGE/DEAM/L) is found exclusively in the Shaker-related subfamily (Kv1). The results show that hetero-oligomerization between alpha and Kv beta 1 subunits is restricted to Shaker-related potassium channel alpha subunits.
journal_name
Neuronjournal_title
Neuronauthors
Sewing S,Roeper J,Pongs Odoi
10.1016/s0896-6273(00)80063-xsubject
Has Abstractpub_date
1996-02-01 00:00:00pages
455-63issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80063-Xjournal_volume
16pub_type
杂志文章相关文献
NEURON文献大全abstract::Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.07.019
更新日期:2018-07-25 00:00:00
abstract::We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are ex...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00799-7
更新日期:2002-08-01 00:00:00
abstract::We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.09.028
更新日期:2005-12-08 00:00:00
abstract::The mammalian genome has hundreds of nuclear-encoded tRNAs, but the contribution of individual tRNA genes to cellular and organismal function remains unknown. Here, we demonstrate that mutations in a neuronally enriched arginine tRNA, n-Tr20, increased seizure threshold and altered synaptic transmission. n-Tr20 expres...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.07.023
更新日期:2020-10-14 00:00:00
abstract::It has recently been found that caspases not only function in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent long-term depression (LTD) of synaptic transmission. It remains unknown, however, how caspases are activated and how neurons escape death in LTD. Here we show that ca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.04.004
更新日期:2011-05-26 00:00:00
abstract::Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments, codes for active agrin. Examination of the sequence reveals cons...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90089-v
更新日期:1992-04-01 00:00:00
abstract::Dopamine is thought to play a critical role in reinforcement learning and goal-directed behavior, but its function in action selection remains largely unknown. Here we demonstrate that nigrostriatal dopamine biases ongoing action selection. When mice were trained to dynamically switch the action selected at different ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.02.029
更新日期:2017-03-22 00:00:00
abstract::Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.06.014
更新日期:2009-07-16 00:00:00
abstract::Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2004.09.013
更新日期:2004-09-30 00:00:00
abstract::Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.06.007
更新日期:2017-07-05 00:00:00
abstract::Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80053-7
更新日期:1996-02-01 00:00:00
abstract::Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.04.023
更新日期:2008-06-12 00:00:00
abstract::Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00500-2
更新日期:2003-08-14 00:00:00
abstract::Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00147-1
更新日期:2000-12-01 00:00:00
abstract::X-ray crystallography has made considerable recent progress in providing static structures of ion channels. Here we describe a complementary method-systematic fluorescence scanning-that reveals the structural dynamics of a channel. Local protein motion was measured from changes in the fluorescent intensity of a fluoro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00068-4
更新日期:2000-09-01 00:00:00
abstract::Mouse vision is based on the parallel output of more than 30 functional types of retinal ganglion cells (RGCs). Little is known about how representations of visual information change between retina and dorsolateral geniculate nucleus (dLGN) of the thalamus, the main relay between retina and cortex. Here, we functional...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.040
更新日期:2019-04-17 00:00:00
abstract::The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result from nigrostriatal deg...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.021
更新日期:2005-08-18 00:00:00
abstract::Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2017.11.002
更新日期:2017-11-15 00:00:00
abstract::Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.12.010
更新日期:2020-01-22 00:00:00
abstract::Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.02.030
更新日期:2019-04-03 00:00:00
abstract::The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90051-5
更新日期:1994-11-01 00:00:00
abstract::The Drosophila Dscams are immunoglobulin superfamily members produced from a single gene that is diversified by alternative splicing to produce a family of cell-surface proteins with over 19,000 different ectodomain isoforms. Dscams are critical for neuronal wiring, and mounting evidence suggests that they play a key ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.024
更新日期:2007-10-04 00:00:00
abstract::Charybdotoxin (CTX) blocks high conductance Ca(2+)-activated K+ channels by binding to a receptor site in the externally facing "mouth." Toxin bound to the channel can be destabilized from its site by K+ entering the channel from the opposite, internal, solution. By analyzing point mutants of CTX expressed in E. coli,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90169-e
更新日期:1992-08-01 00:00:00
abstract::Simultaneous somatic and dendritic recordings were made from the same neocortical layer V pyramidal neuron, and current injection via the dendritic recording pipette was used to simulate the voltage change that occurs during an EPSP. At the soma, these simulated EPSPs increased nonlinearly with the amplitude of the de...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90095-0
更新日期:1995-11-01 00:00:00
abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.03.014
更新日期:2019-04-17 00:00:00
abstract::The functional expression of Ca2+-activated K+ channels (KCa) in developing chick ciliary ganglion (CG) neurons requires interactions with target tissues and preganglionic innervation. Here, we show that the stimulatory effects of target tissues are mediated by an isoform of TGFbeta. Exposure of cultured CG neurons to...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80622-4
更新日期:1998-11-01 00:00:00
abstract::AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90175-y
更新日期:1991-05-01 00:00:00
abstract::Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.07.028
更新日期:2007-09-06 00:00:00
abstract::Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate th...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(02)00831-0
更新日期:2002-08-15 00:00:00
abstract::Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(03)00838-9
更新日期:2004-01-22 00:00:00