Abstract:
:The functional expression of Ca2+-activated K+ channels (KCa) in developing chick ciliary ganglion (CG) neurons requires interactions with target tissues and preganglionic innervation. Here, we show that the stimulatory effects of target tissues are mediated by an isoform of TGFbeta. Exposure of cultured CG neurons to TGFbeta1, but not TGFbeta2 or TGFbeta3, caused robust stimulation of KCa. The KCa stimulatory effects of target tissue extracts were blocked by a neutralizing pan-TGFbeta antiserum but not by specific TGFbeta2 or TGFbeta3 antisera. Intraocular injection of TGFbeta1 caused robust stimulation of KCa, whereas intraocular injection of pan-TGFbeta antiserum inhibited expression of KCa in CG neurons developing in vivo. The effects of TGFbeta1 were potentiated by beta-neuregulin-1, a differentiation factor expressed in preganglionic neurons.
journal_name
Neuronjournal_title
Neuronauthors
Cameron JS,Lhuillier L,Subramony P,Dryer SEdoi
10.1016/s0896-6273(00)80622-4subject
Has Abstractpub_date
1998-11-01 00:00:00pages
1045-53issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80622-4journal_volume
21pub_type
杂志文章相关文献
NEURON文献大全abstract::Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90087-v
更新日期:1990-10-01 00:00:00
abstract::Neuron B19 of Helisoma is selective in synaptogenesis. Presynaptic mechanisms underlying this selectivity were tested. Acetylcholine-sensitive assay cells were micromanipulated into contact with B19 somata to assess its secretory state. Prior to appropriate muscle target contact, spontaneous synaptic currents were det...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90129-n
更新日期:1991-01-01 00:00:00
abstract::A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-tracing assays in developing zebrafish embryos to reconstruct entire retinal lineage...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.06.033
更新日期:2012-09-06 00:00:00
abstract::It is well established that the intraparietal sulcus (IPS) plays an important role in the processing and representation of numerical magnitude. Two recent studies by Piazza et al. and Cohen Kadosh et al. published in this issue of Neuron used fMRI adaptation to explore the extent to which parietal number processing is...
journal_title:Neuron
pub_type: 评论,社论,评审
doi:10.1016/j.neuron.2007.01.001
更新日期:2007-01-18 00:00:00
abstract::Propagation in higher animals requires the efficient and accurate display of innate mating behaviors. In Drosophila melanogaster, male courtship consists of a stereotypic sequence of behaviors involving multiple sensory modalities, such as vision, audition, and chemosensation. For example, taste bristles located in th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00542-7
更新日期:2003-09-11 00:00:00
abstract::Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function. A yeast two-hybrid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF. Lfc was highly expressed in brain, where it interacted with either neurabin ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.05.013
更新日期:2005-07-07 00:00:00
abstract::Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an ea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.11.033
更新日期:2016-01-06 00:00:00
abstract::The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin's effects on stimulating the sympathetic nervous system. We found that leptin activates n...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80656-x
更新日期:1998-12-01 00:00:00
abstract::Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00038-8
更新日期:2004-02-05 00:00:00
abstract::Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.02.026
更新日期:2013-04-24 00:00:00
abstract::An axon is thought to faithfully conduct action potentials to its terminals. However, many features of the axon and axon terminals, especially at inhibitory synapses, remain unknown. By directly recording from the axon and terminal of a cultured cerebellar Purkinje cell (PC), we demonstrate that low membrane excitabil...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.02.013
更新日期:2015-03-18 00:00:00
abstract::The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into opening of its central pore. Here we present the first high-resolution structure of the receptor type found in muscle-endplate membrane and in the muscle-derived e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.03.012
更新日期:2020-06-17 00:00:00
abstract::We describe recent progress toward defining neuronal cell types in the mouse retina and attempt to extract lessons that may be generally useful in the mammalian brain. Achieving a comprehensive catalog of retinal cell types now appears within reach, because researchers have achieved consensus concerning two fundamenta...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2014.08.054
更新日期:2014-09-17 00:00:00
abstract::Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA recept...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.035
更新日期:2005-09-01 00:00:00
abstract::Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force generation underpinned by voltage-dependent conformational changes of the motor protein prestin. However, prestin must be gated by changes in membrane potential on a cycle-by-cycle basis and the periodic component of the recepto...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.04.024
更新日期:2011-06-23 00:00:00
abstract::We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.12.017
更新日期:2011-02-10 00:00:00
abstract::Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.037
更新日期:2013-09-18 00:00:00
abstract::The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.08.019
更新日期:2007-09-20 00:00:00
abstract::The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90107-q
更新日期:1990-04-01 00:00:00
abstract::Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.05.039
更新日期:2015-06-03 00:00:00
abstract::A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.017
更新日期:2016-12-21 00:00:00
abstract::The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excita...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80879-x
更新日期:2000-01-01 00:00:00
abstract::Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.10.040
更新日期:2014-12-03 00:00:00
abstract::Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2004.09.013
更新日期:2004-09-30 00:00:00
abstract::To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00048-0
更新日期:2004-02-19 00:00:00
abstract::To define the cis-acting DNA elements required for rhodopsin expression, we generated lines of transgenic mice carrying sequences upstream of the bovine rhodopsin gene fused to the E. coli beta-galactosidase gene (lacZ). Upstream sequences extending from -2174 to +70 bp, from -734 to +70 bp, and from -222 to +70 bp di...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90355-4
更新日期:1991-02-01 00:00:00
abstract::Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.01.003
更新日期:2015-02-18 00:00:00
abstract::Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term po...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.01.029
更新日期:2007-03-01 00:00:00
abstract::Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00403-3
更新日期:2003-07-17 00:00:00
abstract::Classical patterning molecules that were previously implicated in controlling cell fate choices in the nervous system have recently been shown to play additional roles in axon guidance and synaptogenesis. Bone morphogenetic proteins (BMPs), Sonic hedgehog (Shh), Wnts, and fibroblast growth factors (FGFs) all participa...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.01.002
更新日期:2005-01-20 00:00:00