Abstract:
:Simultaneous somatic and dendritic recordings were made from the same neocortical layer V pyramidal neuron, and current injection via the dendritic recording pipette was used to simulate the voltage change that occurs during an EPSP. At the soma, these simulated EPSPs increased nonlinearly with the amplitude of the dendritic current injection and with depolarization of the membrane potential. Bath application of the sodium channel blocker TTX decreased large (> 5 mV) EPSPs and also blocked amplification of EPSPs at depolarized membrane potentials, whereas calcium channel blockers had little effect. Local application of TTX to the soma and axon blocked EPSP amplification, whereas dendritic application had little effect. Simultaneous somatic and axonal recordings demonstrated that EPSP amplification was largest in the axon. These results show that EPSPs are amplified by voltage-activated sodium channels located close to the soma and in the axon.
journal_name
Neuronjournal_title
Neuronauthors
Stuart G,Sakmann Bdoi
10.1016/0896-6273(95)90095-0subject
Has Abstractpub_date
1995-11-01 00:00:00pages
1065-76issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(95)90095-0journal_volume
15pub_type
杂志文章相关文献
NEURON文献大全abstract::Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodev...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.05.005
更新日期:2016-06-15 00:00:00
abstract::Neuron B19 of Helisoma is selective in synaptogenesis. Presynaptic mechanisms underlying this selectivity were tested. Acetylcholine-sensitive assay cells were micromanipulated into contact with B19 somata to assess its secretory state. Prior to appropriate muscle target contact, spontaneous synaptic currents were det...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90129-n
更新日期:1991-01-01 00:00:00
abstract::We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01191-1
更新日期:2003-02-20 00:00:00
abstract::Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.06.041
更新日期:2013-09-04 00:00:00
abstract::Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80051-9
更新日期:1997-01-01 00:00:00
abstract::Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.04.003
更新日期:2017-05-03 00:00:00
abstract::The Drosophila Dscams are immunoglobulin superfamily members produced from a single gene that is diversified by alternative splicing to produce a family of cell-surface proteins with over 19,000 different ectodomain isoforms. Dscams are critical for neuronal wiring, and mounting evidence suggests that they play a key ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.024
更新日期:2007-10-04 00:00:00
abstract::Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80373-6
更新日期:1997-09-01 00:00:00
abstract::In the developing spinal cord, regional and combinatorial activities of Hox transcription factors are critical in controlling motor neuron fates along the rostrocaudal axis, exemplified by the precise pattern of limb innervation by more than fifty Hox-dependent motor pools. The mechanisms by which motor neuron diversi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.08.008
更新日期:2010-09-09 00:00:00
abstract::Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.12.018
更新日期:2008-01-10 00:00:00
abstract::Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.10.035
更新日期:2020-02-05 00:00:00
abstract::Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.003
更新日期:2006-09-21 00:00:00
abstract::Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.10.032
更新日期:2012-01-12 00:00:00
abstract::To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single uni...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.06.040
更新日期:2017-08-02 00:00:00
abstract::Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(01)00199-4
更新日期:2001-01-01 00:00:00
abstract::The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.07.007
更新日期:2013-07-24 00:00:00
abstract::The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the pre...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.03.010
更新日期:2019-05-22 00:00:00
abstract::Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.01.039
更新日期:2019-03-06 00:00:00
abstract::Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.08.022
更新日期:2018-10-10 00:00:00
abstract::Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01132-7
更新日期:2002-12-19 00:00:00
abstract::Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.08.020
更新日期:2007-11-08 00:00:00
abstract::Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.11.038
更新日期:2006-01-19 00:00:00
abstract::Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an exp...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80801-6
更新日期:1999-07-01 00:00:00
abstract::Neural processing at most stages of the primate visual system is modulated by selective attention, such that behaviorally relevant information is emphasized at the expenses of irrelevant, potentially distracting information. The form of attention best understood at the cellular level is when stimuli at a given locatio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.04.007
更新日期:2007-04-19 00:00:00
abstract::Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse chan...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.11.016
更新日期:2014-12-17 00:00:00
abstract::The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.11.006
更新日期:2011-12-08 00:00:00
abstract::Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function. A yeast two-hybrid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF. Lfc was highly expressed in brain, where it interacted with either neurabin ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.05.013
更新日期:2005-07-07 00:00:00
abstract::Music can be seen as a model system for understanding gene × environment interactions and how these can influence neurocognitive development. The concept of musicality, however, is underspecified and not well understood. Here, I propose a framework for defining musicality to provide a foundation for studying the contr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.01.017
更新日期:2012-02-23 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are membrane spanning proteins with intrinsic kinase activity. Although these receptors are known to be involved in proliferation and differentiation of cells, their roles in regulating central synaptic transmission are largely unknown. In CA1 pyramidal neurons, activation of D2 class ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00859-0
更新日期:2002-09-12 00:00:00
abstract::Opioid neuropeptides and their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavior. In dorsal striatum, which expresses the endogenous opioid enkephalin, patches (or striosomes) are limbic-associated subcompartments enriched in mu opioid receptors. The functional implicati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.11.010
更新日期:2015-12-16 00:00:00