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Sequential Nonlinear Filtering of Local Motion Cues by Global Motion Circuits.

Abstract：

:Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic processing? Here we used in vivo calcium imaging to identify pre- and postsynaptic mechanisms for processing local motion signals in global motion detection circuits in Drosophila. Lobula plate tangential cells (LPTCs) detect global motion by pooling input from local motion detectors, T4/T5 neurons. We show that T4/T5 neurons suppress responses to adjacent local motion signals whereas LPTC dendrites selectively amplify spatiotemporal sequences of local motion signals consistent with preferred global patterns. We propose that sequential nonlinear suppression and amplification operations allow optic flow circuitry to simultaneously prevent saturating responses to local signals while creating selectivity for global motion patterns critical to behavior.

journal_name

Neuron

journal_title

Neuron

authors

Barnhart EL,Wang IE,Wei H,Desplan C,Clandinin TR

doi

10.1016/j.neuron.2018.08.022

subject

Has Abstract

pub_date

2018-10-10 00:00:00

pages

229-243.e3

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(18)30725-6

journal_volume

100

pub_type

杂志文章

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