Abstract：
:Synaptic scaling is a key homeostatic plasticity mechanism and is thought to be involved in the regulation of cortical activity levels. Here we investigated the spatial scale of homeostatic changes in spine size following sensory deprivation in a subset of inhibitory (layer 2/3 GAD65-positive) and excitatory (layer 5 Thy1-positive) neurons in mouse visual cortex. Using repeated in vivo two-photon imaging, we find that increases in spine size are tumor necrosis factor alpha (TNF-α) dependent and thus are likely associated with synaptic scaling. Rather than occurring at all spines, the observed increases in spine size are spatially localized to a subset of dendritic branches and are correlated with the degree of recent local spine loss within that branch. Using simulations, we show that such a compartmentalized form of synaptic scaling has computational benefits over cell-wide scaling for information processing within the cell.
journal_name
Neuronjournal_title
Neuronauthors
Barnes SJ,Franzoni E,Jacobsen RI,Erdelyi F,Szabo G,Clopath C,Keller GB,Keck Tdoi
10.1016/j.neuron.2017.09.052subject
Has Abstractpub_date
2017-11-15 00:00:00pages
871-882.e5issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30921-2journal_volume
96pub_type
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