Abstract：
:A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that controls motor functions and diseases/conditions related to impairments in this circuitry.
journal_name
Neuronjournal_title
Neuronauthors
Gao XB,Horvath TLdoi
10.1016/j.neuron.2011.02.017subject
Has Abstractpub_date
2011-02-24 00:00:00pages
588-90issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00115-2journal_volume
69pub_type
评论,杂志文章相关文献
NEURON文献大全abstract：:Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.05.042
更新日期：2016-07-20 00:00:00
abstract：:By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2016.04.008
更新日期：2016-04-20 00:00:00
abstract：:The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2016.05.012
更新日期：2016-05-18 00:00:00
abstract：:The spatial receptive fields of neurons in medial entorhinal cortex layer II (MECII) and in the hippocampus suggest general and environment-specific maps of space, respectively. However, the relationship between these receptive fields remains unclear. We reversibly manipulated the activity of MECII neurons via chemoge...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.03.001
更新日期：2017-03-22 00:00:00
abstract：:Sensory experience plays an instructive role in the development of the nervous system. Here we showed that visual experience can induce persistent modification of developing retinotectal circuits via spike timing-dependent plasticity (STDP). Pairing light stimuli with spiking of the tectal cell induced persistent enha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.03.009
更新日期：2006-04-06 00:00:00
abstract：:We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90238-m
更新日期：1993-01-01 00:00:00
abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80850-8
更新日期：1999-10-01 00:00:00
abstract：:Among the diverse interneuron subtypes in the neocortex, chandelier cells (ChCs) are the only population that selectively innervate pyramidal neurons (PyNs) at their axon initial segment (AIS), the site of action potential initiation, allowing them to exert powerful control over PyN output. Yet, mechanisms underlying ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.02.009
更新日期：2019-04-17 00:00:00
abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.06.014
更新日期：2004-07-08 00:00:00
abstract：:Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.08.020
更新日期：2007-11-08 00:00:00
abstract：:Adaptation or gain control allows sensory neurons to encode diverse stimuli using a limited range of output signals. Rod vision exemplifies a general challenge facing adaptational mechanisms-balancing the benefits of averaging to create a reliable signal for adaptation with the need to adapt rapidly and locally. The s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.01.031
更新日期：2008-03-27 00:00:00
abstract：:Spontaneous fMRI fluctuations are organized in large-scale spatiotemporal structures, or resting-state networks (RSN). However, it is unknown how task performance affects RSN dynamics. We use MEG to measure slow (∼0.1 Hz) coherent fluctuations of band-limited power (BLP), a robust correlate of RSN, during rest and mov...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.06.022
更新日期：2013-08-21 00:00:00
abstract：:Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.08.014
更新日期：2014-08-20 00:00:00
abstract：:The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2012.10.007
更新日期：2012-10-18 00:00:00
abstract：:We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90166-o
更新日期：1993-04-01 00:00:00
abstract：:Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00038-8
更新日期：2004-02-05 00:00:00
abstract：:The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.06.002
更新日期：2018-07-11 00:00:00
abstract：:Fluorescence imaging has enabled us to decipher spatiotemporal information coded in complex tissues. Genetically encoded probes that enable fluorescence imaging of excitable cell activity have been constructed by fusing fluorescent proteins to functional proteins that are involved in physiological signaling. The probe...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2005.10.003
更新日期：2005-10-20 00:00:00
abstract：:Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90145-6
更新日期：1988-05-01 00:00:00
abstract：:K+ channels contain two main functional domains, an ion-selective pore and a sensor that determines whether the cytoplasmic pore gate is open or closed. In this issue of Neuron, Niu et al. provide compelling evidence that the link between sensor and gate is a remarkably simple mechanical spring. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2004.05.017
更新日期：2004-06-10 00:00:00
abstract：:The combination of patch-clamp and molecular biology techniques has made it possible to characterize the pharmacological and biophysical properties of ion channels in single neurons and to screen for expression of specific mRNAs in the same cell. Following whole-cell recording, the cytoplasm of the cell is harvested, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90257-0
更新日期：1995-06-01 00:00:00
abstract：:Neurotropic viruses that conditionally infect or replicate in molecularly defined neuronal subpopulations, and then spread transsynaptically, are powerful tools for mapping neural pathways. Genetically targetable retrograde transsynaptic tracer viruses are available to map the inputs to specific neuronal subpopulation...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.12.002
更新日期：2011-12-22 00:00:00
abstract：:Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2010.01.015
更新日期：2010-01-28 00:00:00
abstract：:Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.036
更新日期：2014-06-18 00:00:00
abstract：:Nogo-A, a reticulon protein expressed by oligodendrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone collapse and neurite outgrowth in vitro assays, and antibody and inhibitor studies have implicated a role for Nogo in regeneration in the adult CNS in vivo. Three independent l...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00233-2
更新日期：2003-04-24 00:00:00
abstract：:EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.02.003
更新日期：2012-02-23 00:00:00
abstract：:Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.04.014
更新日期：2019-07-03 00:00:00
abstract：:A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.04.010
更新日期：2013-06-05 00:00:00
abstract：:During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.05.020
更新日期：2014-07-02 00:00:00
abstract：:Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2004.10.003
更新日期：2004-10-14 00:00:00
