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Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding.

Abstract：

:Tau is abundant in the axon, whereas MAP2 is found in the cell body and dendrites. To understand their differential localization, we performed transfection studies on primary cultured neurons using tagged tau, MAP2, MAP2C, and their chimeric/deletion mutants. We found that MAP2 was prevented from entering the axon by its N-terminal projection domain and that microtubule binding of tau was stronger in the axon than in the cell body and dendrites, whereas that of MAP2/MAP2C was tighter in the cell body and dendrites than in the axon. These binding properties were determined by their microtubule-binding domains and were suggested to be regulated by phosphorylation, at least in the case of tau. Thus, the suppressed axonal transit of MAP2 and locally regulated microtubule binding may play important roles for their sorting in neurons.

journal_name

Neuron

journal_title

Neuron

authors

Kanai Y,Hirokawa N

doi

10.1016/0896-6273(95)90298-8

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

421-32

issue

2

eissn

0896-6273

issn

1097-4199

pii

0896-6273(95)90298-8

journal_volume

14

pub_type

杂志文章

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