Abstract:
:Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets.
journal_name
Neuronjournal_title
Neuronauthors
Milham MP,Ai L,Koo B,Xu T,Amiez C,Balezeau F,Baxter MG,Blezer ELA,Brochier T,Chen A,Croxson PL,Damatac CG,Dehaene S,Everling S,Fair DA,Fleysher L,Freiwald W,Froudist-Walsh S,Griffiths TD,Guedj C,Hadj-Bouziane F,doi
10.1016/j.neuron.2018.08.039subject
Has Abstractpub_date
2018-10-10 00:00:00pages
61-74.e2issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30768-2journal_volume
100pub_type
杂志文章相关文献
NEURON文献大全abstract::Spontaneous fMRI fluctuations are organized in large-scale spatiotemporal structures, or resting-state networks (RSN). However, it is unknown how task performance affects RSN dynamics. We use MEG to measure slow (∼0.1 Hz) coherent fluctuations of band-limited power (BLP), a robust correlate of RSN, during rest and mov...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.06.022
更新日期:2013-08-21 00:00:00
abstract::In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.04.034
更新日期:2016-06-01 00:00:00
abstract::At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a transcellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to u...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.10.006
更新日期:2017-11-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles of molecules like BDNF in synaptic plasticity with more molecular specificity than is possible using pharmacological approaches. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80140-3
更新日期:1996-06-01 00:00:00
abstract::We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90152-x
更新日期:1994-01-01 00:00:00
abstract::Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2004.09.006
更新日期:2004-09-30 00:00:00
abstract::Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(02)00631-1
更新日期:2002-03-14 00:00:00
abstract::Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefin...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.047
更新日期:2014-06-18 00:00:00
abstract::The mesolimbic system is known to play a role in self-administration of opioids and psychostimulants. Although morphine and cocaine act by separate cellular mechanisms initially, the present study describes a common change in synaptic regulation of dopamine cells in the ventral tegmental area 1 week after termination ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80082-3
更新日期:1996-03-01 00:00:00
abstract::Neuronal responses of sensory cortex are highly variable, and this variability is correlated across neurons. To assess how variability reflects factors shared across a neuronal population, we analyzed the activity of many simultaneously recorded neurons in visual cortex. We developed a simple model that comprises two ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.06.035
更新日期:2015-08-05 00:00:00
abstract::It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00146-6
更新日期:2003-04-10 00:00:00
abstract::I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00570-1
更新日期:2003-09-25 00:00:00
abstract::Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80493-6
更新日期:1998-06-01 00:00:00
abstract::Long-term, but not short-term, facilitation induced by 5-HT in Aplysia sensory neurons is blocked by application of inhibitors of protein synthesis or RNA synthesis during the 1.5 hr training period. These findings suggest that genes and proteins not needed for the short-term process are required for long-term facilit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90046-9
更新日期:1989-06-01 00:00:00
abstract::Serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. However, their functional transmitter repertoire is incompletely known. To investigate this repertoire, intracellular recordings were obtained from 132 cytochemically identified rat mesopontine serotonergic neurons that ha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90283-6
更新日期:1994-02-01 00:00:00
abstract::Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.09.001
更新日期:2007-09-20 00:00:00
abstract::Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80053-7
更新日期:1996-02-01 00:00:00
abstract::Sweet and bitter taste distinguishes good food sources from potential toxins, but what happens when these tastants are mixed? In this issue of Neuron, Jeong et al. (2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the res...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.07.038
更新日期:2013-08-21 00:00:00
abstract::Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.01.021
更新日期:2011-02-10 00:00:00
abstract::Feedback is a ubiquitous anatomical feature of sensory processing in vertebrates. In this issue of Neuron, two papers (Boyd et al., 2012, and Markopoulos et al., 2012) analyze the features of feedback from olfactory cortex to olfactory bulb. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.12.006
更新日期:2012-12-20 00:00:00
abstract::In a recent study in the journal Cell, Tervo et al. (2014) show that animals can implement stochastic choice policies in environments unfavorable to predictive strategies. The shift toward stochastic behavior was driven by noradrenergic signaling in the anterior cingulate cortex. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.09.025
更新日期:2014-10-01 00:00:00
abstract::The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.10.007
更新日期:2012-10-18 00:00:00
abstract::In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.001
更新日期:2010-03-25 00:00:00
abstract::In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.03.012
更新日期:2018-03-21 00:00:00
abstract::The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.06.022
更新日期:2017-07-05 00:00:00
abstract::In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.09.022
更新日期:2017-09-27 00:00:00
abstract::Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.025
更新日期:2018-11-21 00:00:00
abstract::The parietal lobes of nonhuman primates have been well characterized by single neuron recordings, yet clear partitioning of the human parietal lobes has not been clearly demonstrated. An elegant new fMRI study by Simon and colleagues (this issue of Neuron) suggests that parietal cortex does indeed contain dissociable ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(02)00584-6
更新日期:2002-01-31 00:00:00
abstract::Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.03.003
更新日期:2015-04-08 00:00:00
abstract::The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.02.047
更新日期:2017-05-03 00:00:00