Abstract:
:It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with bilateral damage thought to be restricted primarily to the hippocampal region who developed memory impairment at a known time. Since the onset of their memory impairment, the patients have acquired less factual knowledge than controls. The patients also exhibit temporally limited retrograde amnesia for factual information from the several years preceding the onset of memory impairment. Remote memory for factual knowledge (from 11-30 years before amnesia) is intact. The results show that the hippocampal region supports semantic memory as well as episodic memory and that its role in the acquisition and storage of semantic knowledge is time limited.
journal_name
Neuronjournal_title
Neuronauthors
Manns JR,Hopkins RO,Squire LRdoi
10.1016/s0896-6273(03)00146-6subject
Has Abstractpub_date
2003-04-10 00:00:00pages
127-33issue
1eissn
0896-6273issn
1097-4199pii
S0896627303001466journal_volume
38pub_type
杂志文章相关文献
NEURON文献大全abstract::Using a transgenic mouse line in which GFP is expressed in a single population of retinal ganglion cells (RGCs), Huberman and colleagues report in this issue of Neuron that the axon terminals of RGCs exhibit an orderly pattern of distribution in the higher visual centers. This pattern undergoes a developmental refinem...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.08.001
更新日期:2008-08-14 00:00:00
abstract::Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term po...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.01.029
更新日期:2007-03-01 00:00:00
abstract::In this issue of Neuron, a study by Baumgartner et al. investigates the influence of oxytocin on trust behavior and its neural mechanisms. The authors report that, following breaches of trust, oxytocin facilitates prosocial behavior while modulating neural signals in the amygdala and caudate nucleus. The findings have...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.05.005
更新日期:2008-05-22 00:00:00
abstract::During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00586-4
更新日期:2002-01-17 00:00:00
abstract::Dopamine is essential to cognitive functions. However, despite abundant studies demonstrating that dopamine neuron activity is related to reinforcement and motivation, little is known about what signals dopamine neurons convey to promote cognitive processing. We therefore examined dopamine neuron activity in monkeys p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.002
更新日期:2013-09-04 00:00:00
abstract::Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.006
更新日期:2019-12-18 00:00:00
abstract::Immortalized retinal neurons have been established in tissue culture from retinal tumors arising in transgenic mice. The mice carry the SV40 T-antigen under the control of 5' flanking sequences from the human phenylethanolamine N-methyltransferase (PNMT) gene in order to target oncogene expression to adrenergic cell t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90204-s
更新日期:1990-05-01 00:00:00
abstract::The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.05.001
更新日期:2005-05-19 00:00:00
abstract::A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.09.005
更新日期:2011-11-17 00:00:00
abstract::Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90005-5
更新日期:1995-12-01 00:00:00
abstract::Memory abilities differ greatly across individuals. To explore a source of these differences, we characterized the varied strategies people adopt during unconstrained encoding. Participants intentionally encoded object pairs during functional MRI. Principal components analysis applied to a strategy questionnaire revea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.06.006
更新日期:2006-07-20 00:00:00
abstract::Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.12.029
更新日期:2016-02-17 00:00:00
abstract::Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90145-6
更新日期:1988-05-01 00:00:00
abstract::We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01191-1
更新日期:2003-02-20 00:00:00
abstract::The mechanism of kainate receptor targeting and clustering is still unresolved. Here, we demonstrate that members of the SAP90/PSD-95 family colocalize and associate with kainate receptors. SAP90 and SAP102 coimmunoprecipitate with both KA2 and GluR6, but only SAP97 coimmunoprecipitates with GluR6. Similar to NMDA rec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80590-5
更新日期:1998-10-01 00:00:00
abstract::Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.037
更新日期:2013-09-18 00:00:00
abstract::The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.06.030
更新日期:2012-07-26 00:00:00
abstract::Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.03.009
更新日期:2009-03-26 00:00:00
abstract::Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption of MeCP2 S421 phosph...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.08.022
更新日期:2011-10-06 00:00:00
abstract::The prefrontal cortex (PFC) and anterior cingulate cortex (ACC) have both been implicated in cognitive control, but their relative roles remain unclear. Here we recorded the activity of single neurons in both areas while monkeys performed a task that required them to switch between trials in which they had to look tow...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.12.023
更新日期:2007-02-01 00:00:00
abstract::In this issue of Neuron, Winkowski and Knudsen reveal striking parallels between the attentional systems of the barn owl and the rhesus macaque. The observation of close similarities between the attentional systems of such distantly related organisms strongly suggest that key computational principles are at work. ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2008.11.006
更新日期:2008-11-26 00:00:00
abstract::In humans the hippocampus is required for episodic memory, which extends into the spatial and temporal domains. Work on the rodent hippocampus has shown that NMDA receptor (NMDAR) -mediated plasticity is essential for spatial memory. Here, we have examined whether hippocampal NMDARs are also needed for temporal memory...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80909-5
更新日期:2000-02-01 00:00:00
abstract::The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81184-8
更新日期:2000-05-01 00:00:00
abstract::Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00500-2
更新日期:2003-08-14 00:00:00
abstract::Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00080-7
更新日期:2004-03-04 00:00:00
abstract::The spatial distribution of large-scale functional networks on the cerebral cortex differs between individuals and is particularly variable in association networks that are responsible for higher-order cognition. However, it remains unknown how this functional topography evolves in development and supports cognition. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.01.029
更新日期:2020-04-22 00:00:00
abstract::The differentiation of neuronal cell progenitors depends on complex interactions between intrinsic cellular programs and environmental cues. Such interactions have recently been explored using an immortalized sympathoadrenal progenitor cell line, MAH. These studies have revealed that depolarizing conditions, in combin...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90359-x
更新日期:1994-08-01 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00143-6
更新日期:2004-04-08 00:00:00
abstract::The development and homeostasis of neurons relies heavily on the selective targeting of vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in polarized transport; however, the sorting mechanism to exclude dendritic cargo from the axon is unclear. We show that the dynein regulator...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.01.022
更新日期:2016-02-03 00:00:00
abstract::Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.10.003
更新日期:2004-10-14 00:00:00