Semantic memory and the human hippocampus.

Abstract:

:It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with bilateral damage thought to be restricted primarily to the hippocampal region who developed memory impairment at a known time. Since the onset of their memory impairment, the patients have acquired less factual knowledge than controls. The patients also exhibit temporally limited retrograde amnesia for factual information from the several years preceding the onset of memory impairment. Remote memory for factual knowledge (from 11-30 years before amnesia) is intact. The results show that the hippocampal region supports semantic memory as well as episodic memory and that its role in the acquisition and storage of semantic knowledge is time limited.

journal_name

Neuron

journal_title

Neuron

authors

Manns JR,Hopkins RO,Squire LR

doi

10.1016/s0896-6273(03)00146-6

subject

Has Abstract

pub_date

2003-04-10 00:00:00

pages

127-33

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896627303001466

journal_volume

38

pub_type

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