Decision making: singin' in the brain.


:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and necessary and sufficient to trigger male love song.






Benton R




Has Abstract


2011-02-10 00:00:00
















  • Bassoon speeds vesicle reloading at a central excitatory synapse.

    abstract::Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying...


    pub_type: 杂志文章


    authors: Hallermann S,Fejtova A,Schmidt H,Weyhersmüller A,Silver RA,Gundelfinger ED,Eilers J

    更新日期:2010-11-18 00:00:00

  • Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding.

    abstract::Tau is abundant in the axon, whereas MAP2 is found in the cell body and dendrites. To understand their differential localization, we performed transfection studies on primary cultured neurons using tagged tau, MAP2, MAP2C, and their chimeric/deletion mutants. We found that MAP2 was prevented from entering the axon by ...


    pub_type: 杂志文章


    authors: Kanai Y,Hirokawa N

    更新日期:1995-02-01 00:00:00

  • Breaking boundaries in neural-immune interactions.

    abstract::For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...




    authors: McAllister AK,van de Water J

    更新日期:2009-10-15 00:00:00

  • The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions.

    abstract::During Drosophila visual system development, photoreceptor (R) axons choose their correct paths and targets in a step-wise fashion. R axons with different identities make specific pathfinding decisions at different stages during development. We show here that the transmembrane protein Golden goal (Gogo), which is dyna...


    pub_type: 杂志文章


    authors: Tomasi T,Hakeda-Suzuki S,Ohler S,Schleiffer A,Suzuki T

    更新日期:2008-03-13 00:00:00

  • Out of thin air: sensory detection of oxygen and carbon dioxide.

    abstract::Oxygen (O₂) and carbon dioxide (CO₂) levels vary in different environments and locally fluctuate during respiration and photosynthesis. Recent studies in diverse animals have identified sensory neurons that detect these external variations and direct a variety of behaviors. Detection allows animals to stay within a pr...


    pub_type: 杂志文章,评审


    authors: Scott K

    更新日期:2011-01-27 00:00:00

  • Capitalizing on deep brain stimulation: thalamus as a language monitor.

    abstract::In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...


    pub_type: 评论,杂志文章


    authors: Münte TF,Kutas M

    更新日期:2008-09-11 00:00:00

  • Swelling Gliotransmission by SWELL1 Channels.

    abstract::Astrocytes release glutamate, which can modulate nearby synapses, but how this release is accomplished remains debated. In this issue of Neuron, Yang et al. (2019) show that the volume-regulated anion channel Swell1 in astrocytes mediates the release of glutamate and impacts synaptic transmission, learning and memory,...


    pub_type: 评论,杂志文章


    authors: Kofuji P,Araque A

    更新日期:2019-05-22 00:00:00

  • The expected value of control: an integrative theory of anterior cingulate cortex function.

    abstract::The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...


    pub_type: 杂志文章,评审


    authors: Shenhav A,Botvinick MM,Cohen JD

    更新日期:2013-07-24 00:00:00

  • Retrograde axonal transport of LIF is increased by peripheral nerve injury: correlation with increased LIF expression in distal nerve.

    abstract::Leukemia inhibitory factor (LIF) is a cytokine that affects the survival and differentiation of certain neuronal populations in vitro. To identify LIF-responsive neurons in the adult rat, we have demonstrated retrograde axonal transport of 125I-LIF to sensory and motor neurons. The accumulation of 125I-LIF by both cel...


    pub_type: 杂志文章


    authors: Curtis R,Scherer SS,Somogyi R,Adryan KM,Ip NY,Zhu Y,Lindsay RM,DiStefano PS

    更新日期:1994-01-01 00:00:00

  • All-optical histology using ultrashort laser pulses.

    abstract::As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...


    pub_type: 杂志文章


    authors: Tsai PS,Friedman B,Ifarraguerri AI,Thompson BD,Lev-Ram V,Schaffer CB,Xiong Q,Tsien RY,Squier JA,Kleinfeld D

    更新日期:2003-07-03 00:00:00

  • Thalamic Reticular Dysfunction as a Circuit Endophenotype in Neurodevelopmental Disorders.

    abstract::Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...


    pub_type: 杂志文章,评审


    authors: Krol A,Wimmer RD,Halassa MM,Feng G

    更新日期:2018-04-18 00:00:00

  • Competing global representations fail to initiate binocular rivalry.

    abstract::A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...


    pub_type: 杂志文章


    authors: Carlson TA,He S

    更新日期:2004-09-16 00:00:00

  • Tau propagation, different tau phenotypes, and prion-like properties of tau.

    abstract::Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...


    pub_type: 评论,杂志文章


    authors: Hyman BT

    更新日期:2014-06-18 00:00:00

  • Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping.

    abstract::We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-...


    pub_type: 杂志文章


    authors: Sgaier SK,Millet S,Villanueva MP,Berenshteyn F,Song C,Joyner AL

    更新日期:2005-01-06 00:00:00

  • The neural basis of perceptual learning.

    abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...


    pub_type: 杂志文章,评审


    authors: Gilbert CD,Sigman M,Crist RE

    更新日期:2001-09-13 00:00:00

  • Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.

    abstract::During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...


    pub_type: 杂志文章


    authors: Craven SE,El-Husseini AE,Bredt DS

    更新日期:1999-03-01 00:00:00

  • Inactivity sets XL synapses in motion.

    abstract::Neurons adapt their synaptic responses to the activity of the underlying network. In this issue of Neuron, Thiagarajan and colleagues report on specific subcellular mechanisms of homeostasis after prolonged neuronal inactivity. The results have important implications not only for neuronal homeostasis but also for furt...


    pub_type: 评论,杂志文章


    authors: Gundlfinger A,Schmitz D

    更新日期:2005-09-01 00:00:00

  • Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.

    abstract::Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...


    pub_type: 杂志文章


    authors: Alexander GM,Rogan SC,Abbas AI,Armbruster BN,Pei Y,Allen JA,Nonneman RJ,Hartmann J,Moy SS,Nicolelis MA,McNamara JO,Roth BL

    更新日期:2009-07-16 00:00:00

  • EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

    abstract::EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...


    pub_type: 杂志文章


    authors: Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

    更新日期:2012-02-23 00:00:00

  • Unlocking the Potential for Endogenous Repair to Restore Sight.

    abstract::The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...


    pub_type: 杂志文章,评审


    authors: Pearson RA,Ali RR

    更新日期:2018-11-07 00:00:00

  • A genetic push to understand motion detection.

    abstract::Two articles in this issue of Neuron (Eichner et al. and Clark et al.) attack the problem of explaining how neuronal hardware in Drosophila implements the Reichardt motion detector, one of the most famous computational models in neuroscience, which has proven intractable up to now. ...


    pub_type: 评论,杂志文章


    authors: Gabbiani F,Jones PW

    更新日期:2011-06-23 00:00:00

  • Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites.

    abstract::We show that serotonin inhibits synaptic transmission at C. elegans neuromuscular junctions, and we describe a signaling pathway that mediates this effect. Release of acetylcholine from motor neurons was assayed by measuring the sensitivity of intact animals to the acetylcholinesterase inhibitor aldicarb. By this assa...


    pub_type: 杂志文章


    authors: Nurrish S,Ségalat L,Kaplan JM

    更新日期:1999-09-01 00:00:00

  • MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion.

    abstract::The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...


    pub_type: 杂志文章


    authors: Huang X,Cheng HJ,Tessier-Lavigne M,Jin Y

    更新日期:2002-05-16 00:00:00

  • Subthreshold mechanisms underlying state-dependent modulation of visual responses.

    abstract::The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...


    pub_type: 杂志文章


    authors: Bennett C,Arroyo S,Hestrin S

    更新日期:2013-10-16 00:00:00

  • The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor.

    abstract::Neural representations of head direction (HD) have been discovered in many species. Theoretical work has proposed that the dynamics associated with these representations are generated, maintained, and updated by recurrent network structures called ring attractors. We evaluated this theorized structure-function relatio...


    pub_type: 杂志文章


    authors: Turner-Evans DB,Jensen KT,Ali S,Paterson T,Sheridan A,Ray RP,Wolff T,Lauritzen JS,Rubin GM,Bock DD,Jayaraman V

    更新日期:2020-10-14 00:00:00

  • Investigating the Neural Encoding of Emotion with Music.

    abstract::Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...


    pub_type: 杂志文章,评审


    authors: Koelsch S

    更新日期:2018-06-27 00:00:00

  • Calcium signaling in dendrites and spines: practical and functional considerations.

    abstract::Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...


    pub_type: 杂志文章,评审


    authors: Higley MJ,Sabatini BL

    更新日期:2008-09-25 00:00:00

  • Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.

    abstract::Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally changed its mechanism of acti...


    pub_type: 杂志文章


    authors: Zelina P,Blockus H,Zagar Y,Péres A,Friocourt F,Wu Z,Rama N,Fouquet C,Hohenester E,Tessier-Lavigne M,Schweitzer J,Roest Crollius H,Chédotal A

    更新日期:2014-12-17 00:00:00

  • Building neural choice points for love and war.

    abstract::The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...


    pub_type: 评论,杂志文章


    authors: Simerly R

    更新日期:2005-05-19 00:00:00

  • ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.

    abstract::The serine hydrolase α/β-hydrolase domain 6 (ABHD6) hydrolyzes the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and controls its availability at cannabinoid receptors. We show that ABHD6 inhibition decreases pentylenetetrazole (PTZ)-induced generalized tonic-clonic and myoclonic sei...


    pub_type: 杂志文章


    authors: Naydenov AV,Horne EA,Cheah CS,Swinney K,Hsu KL,Cao JK,Marrs W,Blankman JL,Tu S,Cherry AE,Fung S,Wen A,Li W,Saporito MS,Selley DE,Cravatt BF,Oakley JC,Stella N

    更新日期:2014-07-16 00:00:00