Abstract:
:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and necessary and sufficient to trigger male love song.
journal_name
Neuronjournal_title
Neuronauthors
Benton Rdoi
10.1016/j.neuron.2011.01.021subject
Has Abstractpub_date
2011-02-10 00:00:00pages
399-401issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00069-9journal_volume
69pub_type
评论,杂志文章相关文献
NEURON文献大全abstract::Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.03.003
更新日期:2015-04-08 00:00:00
abstract::Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00008-8
更新日期:2000-07-01 00:00:00
abstract::Both human speech and animal vocal signals contain frequency-modulated (FM) sounds. Although central auditory neurons that selectively respond to the direction of frequency modulation are known, the synaptic mechanisms underlying the generation of direction selectivity (DS) remain elusive. Here we show the emergence o...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.11.035
更新日期:2012-03-08 00:00:00
abstract::A proposal for an Australian Brain Initiative (ABI) is under development by members of the Australian Brain Alliance. Here we discuss the goals of the ABI, its areas of research focus, its context in the Australian research setting, and its necessity for ensuring continued success for Australian brain research. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.038
更新日期:2016-11-02 00:00:00
abstract::Habits are notoriously difficult to break and, if broken, are usually replaced by new routines. To examine the neural basis of these characteristics, we recorded spike activity in cortical and striatal habit sites as rats learned maze tasks. Overtraining induced a shift from purposeful to habitual behavior. This shift...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.05.038
更新日期:2013-07-24 00:00:00
abstract::Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.05.039
更新日期:2015-06-03 00:00:00
abstract::mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90277-1
更新日期:1994-02-01 00:00:00
abstract::Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00080-7
更新日期:2004-03-04 00:00:00
abstract::To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single uni...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.06.040
更新日期:2017-08-02 00:00:00
abstract::Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.001
更新日期:2005-07-21 00:00:00
abstract::NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.01.035
更新日期:2014-03-05 00:00:00
abstract::The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81184-8
更新日期:2000-05-01 00:00:00
abstract::The TRPN1 ion channel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in nematodes. In this issue of Neuron, two papers present evidence that TRPN1 is also required for proprioception in fruit fly larvae and that it is a bona fide mechanoreceptor channel for nematode feedin...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.07.022
更新日期:2010-08-12 00:00:00
abstract::A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.02.017
更新日期:2011-02-24 00:00:00
abstract::Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2010.01.015
更新日期:2010-01-28 00:00:00
abstract::Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(03)00838-9
更新日期:2004-01-22 00:00:00
abstract::The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.10.035
更新日期:2018-11-07 00:00:00
abstract::In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.001
更新日期:2010-03-25 00:00:00
abstract::The circadian clock mechanism in the mouse is composed of interlocking transcriptional feedback loops. Two transcription factors, CLOCK and BMAL1, are believed to be essential components of the circadian clock. We have used the Cre-LoxP system to generate whole-animal knockouts of CLOCK and evaluated the resultant cir...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.03.041
更新日期:2006-05-04 00:00:00
abstract::In this issue of Neuron, a study by Baumgartner et al. investigates the influence of oxytocin on trust behavior and its neural mechanisms. The authors report that, following breaches of trust, oxytocin facilitates prosocial behavior while modulating neural signals in the amygdala and caudate nucleus. The findings have...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.05.005
更新日期:2008-05-22 00:00:00
abstract::In situ hybridization histochemistry reveals localized expression of the nicotinic acetylcholine receptor (nAChR) alpha 2 subunit mRNA restricted to the lateral spiriform nucleus (SpL) of the chick diencephalon. The alpha 2 nAChR transcripts are not detected in immature SpL neurons at 4.5-5 days of embryonic developme...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90032-b
更新日期:1990-07-01 00:00:00
abstract::In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic hom...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.09.008
更新日期:2009-09-24 00:00:00
abstract::Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90087-v
更新日期:1990-10-01 00:00:00
abstract::What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.09.013
更新日期:2014-09-17 00:00:00
abstract::NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.04.015
更新日期:2009-05-28 00:00:00
abstract::Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90112-s
更新日期:1990-04-01 00:00:00
abstract::Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81007-7
更新日期:1998-04-01 00:00:00
abstract::The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.044
更新日期:2016-11-02 00:00:00
abstract::Involvement of the cAMP cascade in Drosophila learning and memory is suggested by the aberrant behavioral phenotypes of the mutants dunce (cAMP phosphodiesterase) and rutabaga (adenylyl cyclase). Line DCO581, isolated via an enhancer detector screen for genes preferentially expressed in the mushroom bodies, contains a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90178-t
更新日期:1993-08-01 00:00:00
abstract::In the mammalian olfactory bulb, signal processing is mediated by synaptic interactions between dendrites. Glutamate released from mitral cell dendrites excites dendritic spines of granule cells, which in turn release GABA back onto the mitral cell dendrites, forming a reciprocal synaptic pair. This feedback synaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81065-x
更新日期:2000-03-01 00:00:00