Synaptic glutamate release by postnatal rat serotonergic neurons in microculture.

abstract：:Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...

journal_title：Neuron

authors： Wu GY,Zou DJ,Koothan T,Cline HT

更新日期：1995-04-01 00:00:00

abstract：:Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity i...

journal_title：Neuron

authors： Threlfell S,Lalic T,Platt NJ,Jennings KA,Deisseroth K,Cragg SJ

更新日期：2012-07-12 00:00:00

abstract：:Voltage-gated Na(+) channels are the workhorses of spike generation and propagation in excitable cells. Mutations in Na(+) channel genes have been identified in disorders causing episodic dysfunction of heart, skeletal muscle, and brain. Lossin and colleagues from Al George's lab report in this issue of Neuron that th...

journal_title：Neuron

authors： Cannon SC

更新日期：2002-06-13 00:00:00

abstract：:The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activate...

journal_title：Neuron

authors： Bazelot M,Bocchio M,Kasugai Y,Fischer D,Dodson PD,Ferraguti F,Capogna M

更新日期：2015-09-23 00:00:00

abstract：:Inhibitors in myelin play a major role in preventing spontaneous axonal regeneration after CNS injury. Elevation of cAMP overcomes this inhibition, in a transcription-dependent manner, through the upregulation of Arginase I (Arg I) and increased synthesis of polyamines. Here, we show that the cAMP effect requires acti...

journal_title：Neuron

authors： Gao Y,Deng K,Hou J,Bryson JB,Barco A,Nikulina E,Spencer T,Mellado W,Kandel ER,Filbin MT

更新日期：2004-11-18 00:00:00

abstract：:Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...

journal_title：Neuron

authors： Koelsch S

更新日期：2018-06-27 00:00:00

abstract：:Our understanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of APP to generate amyloid-beta (Abeta), is regulated in Alzheimer's disease (AD) remains incomplete. In this issue of Neuron, O'Connor and coworkers show how energy deprivation, a potential risk factor in AD, tr...

journal_title：Neuron

authors： Wong PC

更新日期：2008-12-26 00:00:00

abstract：:Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...

journal_title：Neuron

authors： Mitchell SJ,Silver RA

更新日期：2003-05-08 00:00:00

abstract：:Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow varia...

journal_title：Neuron

authors： Drew PJ,Mateo C,Turner KL,Yu X,Kleinfeld D

更新日期：2020-09-09 00:00:00

abstract：:A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...

journal_title：Neuron

authors： Murphey RK,Godenschwege TA

更新日期：2002-09-26 00:00:00

abstract：:The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...

journal_title：Neuron

authors： Sandberg M,Flandin P,Silberberg S,Su-Feher L,Price JD,Hu JS,Kim C,Visel A,Nord AS,Rubenstein JLR

更新日期：2016-09-21 00:00:00

abstract：:Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...

journal_title：Neuron

authors： García-Añoveros J,García JA,Liu JD,Corey DP

更新日期：1998-06-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...

journal_title：Neuron

authors： Pearson RA,Dale N,Llaudet E,Mobbs P

更新日期：2005-06-02 00:00:00

abstract：:The bendless (ben) mutation of Drosophila alters synaptic connectivity between a subset of CNS neurons. Here, we show that ben also causes morphological abnormalities within the visual system, suggesting that ben functions in a number of different developmental processes. We show that the ben gene encodes a protein wh...

journal_title：Neuron

authors： Muralidhar MG,Thomas JB

更新日期：1993-08-01 00:00:00

abstract：:Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are loca...

journal_title：Neuron

authors： Moran-Rivard L,Kagawa T,Saueressig H,Gross MK,Burrill J,Goulding M

更新日期：2001-02-01 00:00:00

abstract：:Structure-function studies have identified key functional motifs in the acetylcholine receptor, including residues that contribute to the ion channel and to the ligand-binding sites. Little is known, however, about determinants of channel gating kinetics. To identify structural correlates of gating, we examined the st...

journal_title：Neuron

authors： Bouzat C,Bren N,Sine SM

更新日期：1994-12-01 00:00:00

abstract：:We examined the contribution of the amygdala to value signals within orbital prefrontal cortex (OFC) and medial prefrontal cortex (MFC). On each trial, monkeys chose between two stimuli that were associated with different quantities of reward. In intact monkeys, as expected, neurons in both OFC and MFC signaled the re...

journal_title：Neuron

authors： Rudebeck PH,Mitz AR,Chacko RV,Murray EA

更新日期：2013-12-18 00:00:00

abstract：:Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly....

journal_title：Neuron

authors： Jia Y,Zhao Y,Kusakizako T,Wang Y,Pan C,Zhang Y,Nureki O,Hattori M,Yan Z

更新日期：2020-01-22 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...

journal_title：Neuron

authors： Ninan I,Arancio O

更新日期：2004-04-08 00:00:00

abstract：:Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal life. Full-length TrkB (trkB.FL) as well as truncated TrkB (trkB.t1) were found to be localized primarily to the postsynaptic acetylcholine r...

journal_title：Neuron

authors： Gonzalez M,Ruggiero FP,Chang Q,Shi YJ,Rich MM,Kraner S,Balice-Gordon RJ

更新日期：1999-11-01 00:00:00

abstract：:Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...

journal_title：Neuron

authors： Bozek K,Wei Y,Yan Z,Liu X,Xiong J,Sugimoto M,Tomita M,Pääbo S,Sherwood CC,Hof PR,Ely JJ,Li Y,Steinhauser D,Willmitzer L,Giavalisco P,Khaitovich P

更新日期：2015-02-18 00:00:00

abstract：:Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...

journal_title：Neuron

authors： Barnhart EL,Wang IE,Wei H,Desplan C,Clandinin TR

更新日期：2018-10-10 00:00:00

abstract：:Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapt...

journal_title：Neuron

authors： Jones RS,Carroll RC,Nawy S

更新日期：2012-08-09 00:00:00

abstract：:Distinct brain regions, reproducible from one person to the next, are specialized for processing different kinds of human expertise, such as face recognition and reading. Here, we explore the relationship between age of learning, learning ability, and specialized brain structures. Specifically, we ask whether the exis...

journal_title：Neuron

authors： Srihasam K,Mandeville JB,Morocz IA,Sullivan KJ,Livingstone MS

更新日期：2012-02-09 00:00:00

abstract：:What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...

journal_title：Neuron

authors： Lv C,Zenisek D

更新日期：2014-09-17 00:00:00

abstract：:Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X chromosome-linked PLP gene cause glial cell death and myelin deficiency in jimpy mice and other neurological mutants. As part of an attempt to rescue these mutants by transgenic complementation, we generated normal mouse lines ...

journal_title：Neuron

authors： Readhead C,Schneider A,Griffiths I,Nave KA

更新日期：1994-03-01 00:00:00

abstract：:Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...

journal_title：Neuron

authors： Ahissar E,Arieli A

更新日期：2001-10-25 00:00:00

abstract：:We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...

journal_title：Neuron

authors： Gauthier I,Hayward WG,Tarr MJ,Anderson AW,Skudlarski P,Gore JC

更新日期：2002-03-28 00:00:00

abstract：:Tau is abundant in the axon, whereas MAP2 is found in the cell body and dendrites. To understand their differential localization, we performed transfection studies on primary cultured neurons using tagged tau, MAP2, MAP2C, and their chimeric/deletion mutants. We found that MAP2 was prevented from entering the axon by ...

journal_title：Neuron

authors： Kanai Y,Hirokawa N

更新日期：1995-02-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...

journal_title：Neuron

authors： Ceni C,Barker PA

更新日期：2005-06-16 00:00:00