Abstract:
:Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins, CDC10, displays broad subcellular and tissue distributions and is found in postmitotic neurons as well as dividing cells. Electron microscopic studies showed that the purified rat brain septins form filaments of 8.25 nm in diameter; the lengths of the filaments are multiples of 25 nm. Glutaraldehyde-fixed rat brain sec6/8 complex adopts a conformation resembling the letter "T" or "Y". The sec6/8 and septin complexes likely play an important role in trafficking vesicles and organizing proteins at the plasma membrane of neurons.
journal_name
Neuronjournal_title
Neuronauthors
Hsu SC,Hazuka CD,Roth R,Foletti DL,Heuser J,Scheller RHdoi
10.1016/s0896-6273(00)80493-6subject
Has Abstractpub_date
1998-06-01 00:00:00pages
1111-22issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80493-6journal_volume
20pub_type
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