Abstract：
:Input-timing-dependent plasticity (ITDP) is a circuit-based synaptic learning rule by which paired activation of entorhinal cortical (EC) and Schaffer collateral (SC) inputs to hippocampal CA1 pyramidal neurons (PNs) produces a long-term enhancement of SC excitation. We now find that paired stimulation of EC and SC inputs also induces ITDP of SC excitation of CA2 PNs. However, whereas CA1 ITDP results from long-term depression of feedforward inhibition (iLTD) as a result of activation of CB1 endocannabinoid receptors on cholecystokinin-expressing interneurons, CA2 ITDP results from iLTD through activation of δ-opioid receptors on parvalbumin-expressing interneurons. Furthermore, whereas CA1 ITDP has been previously linked to enhanced specificity of contextual memory, we find that CA2 ITDP is associated with enhanced social memory. Thus, ITDP may provide a general synaptic learning rule for distinct forms of hippocampal-dependent memory mediated by distinct hippocampal regions.
journal_name
Neuronjournal_title
Neuronauthors
Leroy F,Brann DH,Meira T,Siegelbaum SAdoi
10.1016/j.neuron.2017.07.036subject
Has Abstractpub_date
2017-08-30 00:00:00pages
1089-1102.e5issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30684-0journal_volume
95pub_type
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