Abstract：
:Forty years ago, von Békésy demonstrated that the spatial source of an odorant is determined by comparing input across nostrils, but it is unknown how this comparison is effected in the brain. To address this, we delivered odorants to the left or right of the nose, and contrasted olfactory left versus right localization with olfactory identification during brain imaging. We found nostril-specific responses in primary olfactory cortex that were predictive of the accuracy of left versus right localization, thus providing a neural substrate for the behavior described by von Békésy. Additionally, left versus right localization preferentially engaged a portion of the superior temporal gyrus previously implicated in visual and auditory localization, suggesting that localization information extracted from smell was then processed in a convergent brain system for spatial representation of multisensory inputs.
journal_name
Neuronjournal_title
Neuronauthors
Porter J,Anand T,Johnson B,Khan RM,Sobel Ndoi
10.1016/j.neuron.2005.06.028subject
Has Abstractpub_date
2005-08-18 00:00:00pages
581-92issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00534-9journal_volume
47pub_type
杂志文章相关文献
NEURON文献大全abstract：:Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00966-2
更新日期：2002-10-24 00:00:00
abstract：:In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.05.029
更新日期：2010-06-10 00:00:00
abstract：:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently described neurodegenerative disorder of older adult carriers of premutation alleles (60-200 CGG repeats) in the fragile X mental retardation gene (FMR1). It has been proposed that FXTAS is an RNA-mediated neurodegenerative disease caused by the titratio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.07.021
更新日期：2007-08-16 00:00:00
abstract：:New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.03.029
更新日期：2015-04-08 00:00:00
abstract：:The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.02.035
更新日期：2013-05-08 00:00:00
abstract：:The level of electrotonic coupling in the inferior olive is extremely high, but its functional role in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary coupling to paradigms that require learning-dependent timing. Cx36-deficient mice showed impaired timing of both locomotion and eye-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.03.016
更新日期：2008-05-22 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K)-dependent phosphoinositide signaling has been implicated in diverse cellular systems coupled to receptors for many different ligands, but the extent to which it functions in sensory transduction is yet to be determined. We now report that blocking PI3K activity increases odorant-ev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00610-4
更新日期：2002-02-28 00:00:00
abstract：:Despite the best available medical treatments, many patients continue to be disabled by neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging and neurophysiology over the last two decades have led to a reinterpretation of some neurologic and psychiatric conditions as primarily diso...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.01.020
更新日期：2013-02-06 00:00:00
abstract：:Input-timing-dependent plasticity (ITDP) is a circuit-based synaptic learning rule by which paired activation of entorhinal cortical (EC) and Schaffer collateral (SC) inputs to hippocampal CA1 pyramidal neurons (PNs) produces a long-term enhancement of SC excitation. We now find that paired stimulation of EC and SC in...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.07.036
更新日期：2017-08-30 00:00:00
abstract：:The trigeminal loop in the brainstem comprises the innermost level of sensorimotor feedback in the rat vibrissa system. Anatomy suggests that this loop relays tactile information from the vibrissae to the motoneurons that control vibrissa movement. We demonstrate, using in vitro and in vivo recordings, that the trigem...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.12.042
更新日期：2005-02-03 00:00:00
abstract：:Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90260-2
更新日期：1989-09-01 00:00:00
abstract：:Particle-mediated gene transfer and two-photon microscopy were used to monitor the behavior of dendrites of individual cortical pyramidal neurons coexpressing green fluorescent protein (GFP) and brain-derived neurotrophic factor (BDNF). While the dendrites and spines of neurons expressing GFP alone grew modestly over ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80785-0
更新日期：1999-06-01 00:00:00
abstract：:Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.03.019
更新日期：2005-04-21 00:00:00
abstract：:We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80996-4
更新日期：1998-03-01 00:00:00
abstract：:Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.03.015
更新日期：2011-04-14 00:00:00
abstract：:We used fMRI to investigate how moment-to-moment neural activity contributes to success or failure on individual trials of a visual working memory (WM) task. We found that different nodes of a distributed cortical network were activated to a greater extent for correct compared to incorrect trials during stimulus encod...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00817-6
更新日期：2002-08-29 00:00:00
abstract：:beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80179-8
更新日期：1996-09-01 00:00:00
abstract：:The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00672-4
更新日期：2002-05-16 00:00:00
abstract：:In the developing spinal cord, regional and combinatorial activities of Hox transcription factors are critical in controlling motor neuron fates along the rostrocaudal axis, exemplified by the precise pattern of limb innervation by more than fifty Hox-dependent motor pools. The mechanisms by which motor neuron diversi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.08.008
更新日期：2010-09-09 00:00:00
abstract：:Activation of kainate receptors causes Co2+ influx into neurons, type-2 astrocytes, and O-2A progenitor cells. Agonist-activated Co2+ uptake can be performed using cultured cells or fresh tissue slices. Based on the pattern of response to kainate, glutamate, and quisqualate, three functionally different kainate-activa...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90302-g
更新日期：1991-09-01 00:00:00
abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.01.023
更新日期：2017-02-22 00:00:00
abstract：:A coculture system consisting of input axons from entorhinal cortex explants and target hippocampal pyramidal neurons was used to demonstrate that glutamate, released spontaneously from afferent axons, can influence both dendritic geometry of target neurons and formation of presumptive synaptic sites. Dendritic outgro...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90134-1
更新日期：1988-11-01 00:00:00
abstract：:Neurons compensate their synaptic strengths to global changes in network activity. In this issue of Neuron, Lee et al. (2013) provide evidence in mature hippocampal networks that this homeostatic plasticity is achieved uniquely at the mossy fiber synapses on CA3 neurons. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2012.12.024
更新日期：2013-01-09 00:00:00
abstract：:We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2020.01.026
更新日期：2020-03-04 00:00:00
abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90139-5
更新日期：1992-06-01 00:00:00
abstract：:Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2010.10.007
更新日期：2010-10-21 00:00:00
abstract：:The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00368-4
更新日期：2003-07-03 00:00:00
abstract：:Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.04.003
更新日期：2017-05-03 00:00:00
abstract：:The Neurodata Without Borders (NWB) initiative promotes data standardization in neuroscience to increase research reproducibility and opportunities. In the first NWB pilot project, neurophysiologists and software developers produced a common data format for recordings and metadata of cellular electrophysiology and opt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.10.025
更新日期：2015-11-18 00:00:00
abstract：:Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.02.040
更新日期：2016-04-06 00:00:00
