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GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.

Abstract：

:Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequences of selective Ube3a loss from either GABAergic or glutamatergic neurons, focusing on the development of hyperexcitability within L2/3 neocortex and in broader circuit and behavioral contexts. We find that GABAergic Ube3a loss causes AS-like increases in neocortical EEG delta power, enhances seizure susceptibility, and leads to presynaptic accumulation of clathrin-coated vesicles (CCVs)-all without decreasing GABAergic inhibition onto L2/3 pyramidal neurons. Conversely, glutamatergic Ube3a loss fails to yield EEG abnormalities, seizures, or associated CCV phenotypes, despite impairing tonic inhibition onto L2/3 pyramidal neurons. These results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in AS mice, lending insight into ictogenic mechanisms in AS.

journal_name

Neuron

journal_title

Neuron

authors

Judson MC,Wallace ML,Sidorov MS,Burette AC,Gu B,van Woerden GM,King IF,Han JE,Zylka MJ,Elgersma Y,Weinberg RJ,Philpot BD

doi

10.1016/j.neuron.2016.02.040

subject

Has Abstract

pub_date

2016-04-06 00:00:00

pages

56-69

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(16)00177-X

journal_volume

90

pub_type

杂志文章

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