Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons.

abstract：:Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...

journal_title：Neuron

authors： Miller BT,D'Esposito M

更新日期：2005-11-23 00:00:00

abstract：:The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...

journal_title：Neuron

authors： Harris KD

更新日期：2012-10-18 00:00:00

abstract：:Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that opto...

journal_title：Neuron

authors： Kim J,Kim Y,Nakajima R,Shin A,Jeong M,Park AH,Jeong Y,Jo S,Yang S,Park H,Cho SH,Cho KH,Shim I,Chung JH,Paik SB,Augustine GJ,Kim D

更新日期：2017-08-30 00:00:00

abstract：:Screens for genes that orchestrate neural circuit formation in mammals have been hindered by practical constraints of germline mutagenesis. To overcome these limitations, we combined RNA-seq with somatic CRISPR mutagenesis to study synapse development in the mouse retina. Here synapses occur between cellular layers, f...

journal_title：Neuron

authors： Sarin S,Zuniga-Sanchez E,Kurmangaliyev YZ,Cousins H,Patel M,Hernandez J,Zhang KX,Samuel MA,Morey M,Sanes JR,Zipursky SL

更新日期：2018-04-04 00:00:00

abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...

journal_title：Neuron

authors： Wu YE,Huo L,Maeder CI,Feng W,Shen K

更新日期：2013-06-19 00:00:00

abstract：:The release of neurotransmitter-filled vesicles after action potentials occurs with discrete time courses: submillisecond phasic release that can be desynchronized by activity followed by "delayed release" that persists for tens of milliseconds. Delayed release has a well-established role in synaptic integration, but ...

journal_title：Neuron

authors： Rudolph S,Overstreet-Wadiche L,Wadiche JI

更新日期：2011-06-09 00:00:00

abstract：:Rostrocaudal polarity of the tectum is first detectable at embryonic day 2 (E2) in the chick by the rostrocaudal gradient of en expression. When ectopic tectum is produced by heterotopic transplantation at E2 in the diencephalon, the gradient of en expression is inverted from the host polarity by environmental influen...

journal_title：Neuron

authors： Itasaki N,Nakamura H

更新日期：1992-04-01 00:00:00

abstract：:Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...

journal_title：Neuron

authors： Deiner MS,Kennedy TE,Fazeli A,Serafini T,Tessier-Lavigne M,Sretavan DW

更新日期：1997-09-01 00:00:00

abstract：:Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...

journal_title：Neuron

authors： Stepanyants A,Tamás G,Chklovskii DB

更新日期：2004-07-22 00:00:00

abstract：:A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...

journal_title：Neuron

authors： Keck T,Scheuss V,Jacobsen RI,Wierenga CJ,Eysel UT,Bonhoeffer T,Hübener M

更新日期：2011-09-08 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:In this issue, Doucette and colleagues demonstrate that information related to whether an odor is currently linked to reward can be observed uniquely in population activity in the olfactory bulb, changing our understanding both of what is coded by the first olfactory relay in the CNS and of how this coding is instanti...

journal_title：Neuron

authors： Katz DB,Maier JX

更新日期：2011-03-24 00:00:00

abstract：:Visual attention has been classically described as a spotlight that enhances the processing of a behaviorally relevant object. However, in many situations, humans and animals must simultaneously attend to several relevant objects separated by distracters. To account for this ability, various models of attention have b...

journal_title：Neuron

authors： Niebergall R,Khayat PS,Treue S,Martinez-Trujillo JC

更新日期：2011-12-22 00:00:00

abstract：:Inhibitors in myelin play a major role in preventing spontaneous axonal regeneration after CNS injury. Elevation of cAMP overcomes this inhibition, in a transcription-dependent manner, through the upregulation of Arginase I (Arg I) and increased synthesis of polyamines. Here, we show that the cAMP effect requires acti...

journal_title：Neuron

authors： Gao Y,Deng K,Hou J,Bryson JB,Barco A,Nikulina E,Spencer T,Mellado W,Kandel ER,Filbin MT

更新日期：2004-11-18 00:00:00

abstract：:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...

journal_title：Neuron

authors： Cummings JA,Mulkey RM,Nicoll RA,Malenka RC

更新日期：1996-04-01 00:00:00

abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...

journal_title：Neuron

authors： Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

更新日期：2013-07-10 00:00:00

abstract：:Acetylcholine release in the prefrontal cortex (PFC), acting through muscarinic receptors, has an essential role in regulating flexible behavior and working memory (WM). General muscarinic receptor blockade disrupts PFC WM representations, while selective stimulation of muscarinic receptor subtypes is of great interes...

journal_title：Neuron

authors： Vijayraghavan S,Major AJ,Everling S

更新日期：2018-06-27 00:00:00

abstract：:Neuronal development is characterized by a period of exuberant synaptic growth that is well studied. However, the mechanisms that restrict this process are less clear. Here we demonstrate that glycosylphosphatidylinositol-anchored cell-surface receptors of the Nogo Receptor family (NgR1, NgR2, and NgR3) restrict excit...

journal_title：Neuron

authors： Wills ZP,Mandel-Brehm C,Mardinly AR,McCord AE,Giger RJ,Greenberg ME

更新日期：2012-02-09 00:00:00

abstract：:We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2017-05-17 00:00:00

abstract：:Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...

journal_title：Neuron

authors： Belujon P,Grace AA

更新日期：2011-09-08 00:00:00

abstract：:Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...

journal_title：Neuron

authors： Barnhart EL,Wang IE,Wei H,Desplan C,Clandinin TR

更新日期：2018-10-10 00:00:00

abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...

journal_title：Neuron

authors： Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH

更新日期：2000-12-01 00:00:00

abstract：:Although pain is defined as a sensory and emotional experience, it is traditionally researched and clinically treated separately from emotion. Conceptual and mechanistic relationships between these constructs highlight the need for better understanding of their bi-directional influences and the value of bridging the p...

journal_title：Neuron

authors： Gilam G,Gross JJ,Wager TD,Keefe FJ,Mackey SC

更新日期：2020-07-08 00:00:00

abstract：:The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...

journal_title：Neuron

authors： Buckley MJ,Sigala N

更新日期：2010-05-27 00:00:00

abstract：:In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drink...

journal_title：Neuron

authors： Lechner SG,Markworth S,Poole K,Smith ES,Lapatsina L,Frahm S,May M,Pischke S,Suzuki M,Ibañez-Tallon I,Luft FC,Jordan J,Lewin GR

更新日期：2011-01-27 00:00:00

abstract：:Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca(2+)-dependent Cl- conductance, and the Ca2+ to Cs+ permeability ratio (PCa/PCs) is 7 times greater...

journal_title：Neuron

authors： Vernino S,Amador M,Luetje CW,Patrick J,Dani JA

更新日期：1992-01-01 00:00:00

abstract：:Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa. The predicted sequences of these proteins differ by...

journal_title：Neuron

authors： Adelman JP,Shen KZ,Kavanaugh MP,Warren RA,Wu YN,Lagrutta A,Bond CT,North RA

更新日期：1992-08-01 00:00:00

abstract：:The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a ...

journal_title：Neuron

authors： Annaert WG,Esselens C,Baert V,Boeve C,Snellings G,Cupers P,Craessaerts K,De Strooper B

更新日期：2001-11-20 00:00:00

abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...

journal_title：Neuron

authors： Grossmann T,Oberecker R,Koch SP,Friederici AD

更新日期：2010-03-25 00:00:00

abstract：:In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. ...

journal_title：Neuron

authors： Esquivelzeta Rabell J,Haesler S

更新日期：2020-10-28 00:00:00