Abstract：
:Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstructions of pairs consisting of pyramidal cells (PCs) and GABAergic interneurons (GIs) revealed that the layout of GI axons is specific. This specificity is manifested in a relatively high tortuosity, small branch length of these axons, and correlations of their trajectories with the positions of postsynaptic neuron dendrites. Axons of PCs show no such specificity, usually taking a relatively straight course through neuropil. However, wiring patterns among PCs hold a large potential for circuit remodeling and specificity through growth and retraction of dendritic spines. Our results define distinct class-specific rules in establishing synaptic connectivity, which could be crucial in formulating a canonical cortical circuit.
journal_name
Neuronjournal_title
Neuronauthors
Stepanyants A,Tamás G,Chklovskii DBdoi
10.1016/j.neuron.2004.06.013subject
Has Abstractpub_date
2004-07-22 00:00:00pages
251-9issue
2eissn
0896-6273issn
1097-4199pii
S0896627304003629journal_volume
43pub_type
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