Spatial segregation of adaptation and predictive sensitization in retinal ganglion cells.

abstract：:We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, tr...

journal_title：Neuron

authors： Chaudhuri R,Knoblauch K,Gariel MA,Kennedy H,Wang XJ

更新日期：2015-10-21 00:00:00

abstract：:The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from...

journal_title：Neuron

authors： Koleske AJ,Gifford AM,Scott ML,Nee M,Bronson RT,Miczek KA,Baltimore D

更新日期：1998-12-01 00:00:00

abstract：:A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...

journal_title：Neuron

authors： Kawano T,Po MD,Gao S,Leung G,Ryu WS,Zhen M

更新日期：2011-11-17 00:00:00

abstract：:Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed tha...

journal_title：Neuron

authors： Cao VY,Ye Y,Mastwal S,Ren M,Coon M,Liu Q,Costa RM,Wang KH

更新日期：2015-06-17 00:00:00

abstract：:There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the...

journal_title：Neuron

authors： McIntosh AM,Sullivan PF,Lewis CM

更新日期：2019-04-03 00:00:00

abstract：:Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...

journal_title：Neuron

authors： Cantrell AR,Ma JY,Scheuer T,Catterall WA

更新日期：1996-05-01 00:00:00

abstract：:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...

journal_title：Neuron

authors： Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KN

更新日期：2008-09-25 00:00:00

abstract：:Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identifie...

journal_title：Neuron

authors： Hasan MT,Althammer F,Silva da Gouveia M,Goyon S,Eliava M,Lefevre A,Kerspern D,Schimmer J,Raftogianni A,Wahis J,Knobloch-Bollmann HS,Tang Y,Liu X,Jain A,Chavant V,Goumon Y,Weislogel JM,Hurlemann R,Herpertz SC,Pitzer

更新日期：2019-07-03 00:00:00

abstract：:The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...

journal_title：Neuron

authors： Singh KK,Ge X,Mao Y,Drane L,Meletis K,Samuels BA,Tsai LH

更新日期：2010-07-15 00:00:00

abstract：:We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...

journal_title：Neuron

authors： Stansfeld CE,Marsh SJ,Gibb AJ,Brown DA

更新日期：1993-04-01 00:00:00

abstract：:Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation. ...

journal_title：Neuron

authors： Pinheiro EM,Gertler FB

更新日期：2006-09-21 00:00:00

abstract：:Genomic disorders are a group of human genetic diseases caused by genomic rearrangements resulting in copy-number variation (CNV) affecting a dosage-sensitive gene or genes critical for normal development or maintenance. These disorders represent a wide range of clinically distinct entities but include many diseases a...

journal_title：Neuron

authors： Lee JA,Lupski JR

更新日期：2006-10-05 00:00:00

abstract：:RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...

journal_title：Neuron

authors： Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

更新日期：2019-04-17 00:00:00

abstract：:Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...

journal_title：Neuron

authors： Alcamo EA,Chirivella L,Dautzenberg M,Dobreva G,Fariñas I,Grosschedl R,McConnell SK

更新日期：2008-02-07 00:00:00

abstract：:Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol ph...

journal_title：Neuron

authors： Wenk MR,Pellegrini L,Klenchin VA,Di Paolo G,Chang S,Daniell L,Arioka M,Martin TF,De Camilli P

更新日期：2001-10-11 00:00:00

abstract：:Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are loca...

journal_title：Neuron

authors： Moran-Rivard L,Kagawa T,Saueressig H,Gross MK,Burrill J,Goulding M

更新日期：2001-02-01 00:00:00

abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...

journal_title：Neuron

authors： Moore SJ,Cooper DC,Spruston N

更新日期：2009-01-29 00:00:00

abstract：:The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...

journal_title：Neuron

authors： Buckley MJ,Sigala N

更新日期：2010-05-27 00:00:00

abstract：:Neural processing at most stages of the primate visual system is modulated by selective attention, such that behaviorally relevant information is emphasized at the expenses of irrelevant, potentially distracting information. The form of attention best understood at the cellular level is when stimuli at a given locatio...

journal_title：Neuron

authors： Mirabella G,Bertini G,Samengo I,Kilavik BE,Frilli D,Della Libera C,Chelazzi L

更新日期：2007-04-19 00:00:00

abstract：:The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excita...

journal_title：Neuron

authors： Schinder AF,Berninger B,Poo M

更新日期：2000-01-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) can be regulated by synaptic activity and could therefore be involved in activity-dependent control of neuronal growth. We tested whether increased CaMKII activity in postsynaptic optic tectal neurons can modify the development of retinotectal axons in Xenopus. T...

journal_title：Neuron

authors： Zou DJ,Cline HT

更新日期：1996-03-01 00:00:00

abstract：:The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a ...

journal_title：Neuron

authors： Annaert WG,Esselens C,Baert V,Boeve C,Snellings G,Cupers P,Craessaerts K,De Strooper B

更新日期：2001-11-20 00:00:00

abstract：:The M current regulates neuronal excitability, with its amplitude resulting from high open probability modal M channel behavior. The M current is affected by changing intracellular calcium levels. It is proposed that internal calcium acts by regulating M channel modal gating. Intracellular application of a preactivate...

journal_title：Neuron

authors： Marrion NV

更新日期：1996-01-01 00:00:00

abstract：:Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...

journal_title：Neuron

authors： Yao XP,Cheng X,Wang C,Zhao M,Guo XX,Su HZ,Lai LL,Zou XH,Chen XJ,Zhao Y,Dong EL,Lu YQ,Wu S,Li X,Fan G,Yu H,Xu J,Wang N,Xiong ZQ,Chen WJ

更新日期：2018-06-27 00:00:00

abstract：:Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schiz...

journal_title：Neuron

authors： Bundo M,Toyoshima M,Okada Y,Akamatsu W,Ueda J,Nemoto-Miyauchi T,Sunaga F,Toritsuka M,Ikawa D,Kakita A,Kato M,Kasai K,Kishimoto T,Nawa H,Okano H,Yoshikawa T,Kato T,Iwamoto K

更新日期：2014-01-22 00:00:00

abstract：:Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2016-10-19 00:00:00

abstract：:T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3...

journal_title：Neuron

authors： García-Caballero A,Gadotti VM,Stemkowski P,Weiss N,Souza IA,Hodgkinson V,Bladen C,Chen L,Hamid J,Pizzoccaro A,Deage M,François A,Bourinet E,Zamponi GW

更新日期：2014-09-03 00:00:00

abstract：:The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin prep...

journal_title：Neuron

authors： Bartsch U,Bandtlow CE,Schnell L,Bartsch S,Spillmann AA,Rubin BP,Hillenbrand R,Montag D,Schwab ME,Schachner M

更新日期：1995-12-01 00:00:00

abstract：:Innate defense behaviors (IDBs) evoked by threatening sensory stimuli are essential for animal survival. Although subcortical circuits are implicated in IDBs, it remains largely unclear whether sensory cortex modulates IDBs and what the underlying neural pathways are. Here, we show that optogenetic silencing of cortic...

journal_title：Neuron

authors： Liang F,Xiong XR,Zingg B,Ji XY,Zhang LI,Tao HW

更新日期：2015-05-06 00:00:00

abstract：:When speaking, we dynamically coordinate movements of our jaw, tongue, lips, and larynx. To investigate the neural mechanisms underlying articulation, we used direct cortical recordings from human sensorimotor cortex while participants spoke natural sentences that included sounds spanning the entire English phonetic i...

journal_title：Neuron

authors： Chartier J,Anumanchipalli GK,Johnson K,Chang EF

更新日期：2018-06-06 00:00:00