Abstract:
:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional experience during cognitive reappraisal of aversive images. We then applied a pathway-mapping analysis on subcortical regions to locate mediators of the association between vlPFC activity and reappraisal success (i.e., reductions in reported emotion). Results identified two separable pathways that together explained approximately 50% of the reported variance in self-reported emotion: (1) a path through nucleus accumbens that predicted greater reappraisal success, and (2) a path through ventral amygdala that predicted reduced reappraisal success (i.e., more negative emotion). These results provide direct evidence that vlPFC is involved in both the generation and regulation of emotion through different subcortical pathways, suggesting a general role for this region in appraisal processes.
journal_name
Neuronjournal_title
Neuronauthors
Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KNdoi
10.1016/j.neuron.2008.09.006subject
Has Abstractpub_date
2008-09-25 00:00:00pages
1037-50issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(08)00753-8journal_volume
59pub_type
杂志文章相关文献
NEURON文献大全abstract::Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01026-7
更新日期:2002-11-14 00:00:00
abstract::Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.11.002
更新日期:2005-11-23 00:00:00
abstract::Cell proliferation during successive stages of oligodendrocyte development was delineated in the rat brain and optic nerve. Surface antigens, A2B5, O4, and galactocerebroside (GalC) identified three cell populations emerging in sequence; the incorporation of bromodeoxyuridine into newly synthesized DNA identified the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90216-3
更新日期:1990-11-01 00:00:00
abstract::Data on neuropsychiatric and behavioral genetics have attracted legal interest, as attorneys explore their use in criminal and civil cases. These developments may assist judges and juries in making difficult judgments-but they bring substantial risk of misinterpretation and misuse. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.026
更新日期:2014-06-04 00:00:00
abstract::Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate th...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(02)00831-0
更新日期:2002-08-15 00:00:00
abstract::GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is unknown whether they contribute to pre- as well as postsynaptic functions. Here, we demonstrate tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00345-2
更新日期:2001-07-19 00:00:00
abstract::Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.05.024
更新日期:2013-07-10 00:00:00
abstract::A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.08.031
更新日期:2009-09-10 00:00:00
abstract::C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80302-5
更新日期:1997-04-01 00:00:00
abstract::Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.01.041
更新日期:2018-02-07 00:00:00
abstract::Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2010.08.028
更新日期:2010-09-09 00:00:00
abstract::Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.07.037
更新日期:2014-09-03 00:00:00
abstract::Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate projection from the prefrontal cortex (PFC) to the nucleus accumbens have been discovered in rats withdrawn from cocaine that may underl...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.02.005
更新日期:2005-03-03 00:00:00
abstract::Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81174-5
更新日期:2000-05-01 00:00:00
abstract::Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...
journal_title:Neuron
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuron.2013.10.038
更新日期:2013-10-30 00:00:00
abstract::Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.030
更新日期:2016-12-07 00:00:00
abstract::Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption of MeCP2 S421 phosph...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.08.022
更新日期:2011-10-06 00:00:00
abstract::Direct brain stimulation has diverse effects on network activity. In this issue of Neuron, Qiao et al. (2020) demonstrate a novel approach for using stimulation to characterize and modulate interactions between areas of the mood processing network. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.08.008
更新日期:2020-09-09 00:00:00
abstract::Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computat...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2006.02.010
更新日期:2006-03-02 00:00:00
abstract::In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.12.034
更新日期:2019-01-16 00:00:00
abstract::Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90466-9
更新日期:1994-07-01 00:00:00
abstract::The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M II, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protonation regulates this...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90274-h
更新日期:1992-03-01 00:00:00
abstract::Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.06.009
更新日期:2004-06-24 00:00:00
abstract::A fundamental question about the neural correlates of attention concerns the earliest sensory processing stage that it can affect. We addressed this issue by recording magnetoencephalography (MEG) signals while subjects performed detection tasks, which required employment of spatial or nonspatial attention, in auditor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.04.013
更新日期:2008-06-12 00:00:00
abstract::The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca(2+) imaging from genetica...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.06.021
更新日期:2015-07-15 00:00:00
abstract::The M current regulates neuronal excitability, with its amplitude resulting from high open probability modal M channel behavior. The M current is affected by changing intracellular calcium levels. It is proposed that internal calcium acts by regulating M channel modal gating. Intracellular application of a preactivate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80033-1
更新日期:1996-01-01 00:00:00
abstract::The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00236-7
更新日期:2001-03-01 00:00:00
abstract::The peripheral terminals of primary nociceptive neurons play an essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and capsaicin. However, the contribution of central terminal TRPV1 in the dorsal horn to chronic pain has not been investigated directly. Combining prim...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.12.011
更新日期:2014-02-19 00:00:00
abstract::Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90145-6
更新日期:1988-05-01 00:00:00
abstract::Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.08.024
更新日期:2017-09-13 00:00:00